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1.
46404 Accesses
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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Douglas B Kell BMC Medical Genomics 2009, 2:2 (8 January 2009)
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| PubMed | Cited on BioMed Central
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Editor’s summary
Douglas Kell reviews the role of iron-catalysed free radicals in disease, which underpin the behavior of many physiological and pathological processes, and considers the need for better understanding using an integrative, systems-level approach.
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2.
9950 Accesses
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Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes
Jac C Charlesworth, Joanne E Curran, Matthew P Johnson, Harald HH Göring, Thomas D Dyer, Vincent P Diego, Jack W Kent, Michael C Mahaney, Laura Almasy, Jean W MacCluer, Eric K Moses, John Blangero BMC Medical Genomics 2010, 3:29 (15 July 2010)
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| PubMed | Cited on BioMed Central
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Editor’s summary
Cigarette smoking influences the expression of large networks of genes within a range of functional categories including immune response, cell death, cancer, natural killer cell signaling and xenobiotic metabolism, offering insights into induced system-wide pathological processes.
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3.
9626 Accesses
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Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
Christopher G Bell, Andrew E Teschendorff, Vardhman K Rakyan, Alexander P Maxwell, Stephan Beck, David A Savage BMC Medical Genomics 2010, 3:33 (5 August 2010)
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4.
9438 Accesses
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A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors
Andrey Loboda, Michael Nebozhyn, Rich Klinghoffer, Jason Frazier, Michael Chastain, William Arthur, Brian Roberts, Theresa Zhang, Melissa Chenard, Brian Haines, Jannik Andersen, Kumiko Nagashima, Cloud Paweletz, Bethany Lynch, Igor Feldman, Hongyue Dai, Pearl Huang, James Watters BMC Medical Genomics 2010, 3:26 (30 June 2010)
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5.
8861 Accesses
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Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: Efficient identification of known microduplications and identification of a novel microduplication in ASMT
Guiqing Cai, Lisa Edelmann, Juliet E Goldsmith, Ninette Cohen, Alisa Nakamine, Jennifer G Reichert, Ellen J Hoffman, Danielle M Zurawiecki, Jeremy M Silverman, Eric Hollander, Latha Soorya, Evdokia Anagnostou, Catalina Betancur, Joseph D Buxbaum BMC Medical Genomics 2008, 1:50 (16 October 2008)
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Editor’s summary
Multiplex ligation-dependent probe amplification (MPLA) identifies known and novel chromosomal abnormalities in children with autism spectrum disorders and associated cognitive impairment, suggesting that MPLA has the potential to be an effective screening method for these conditions.
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6.
8821 Accesses
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Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities
Reinhold J Medina, Christina L O'Neill, Mark Sweeney, Jasenka Guduric-Fuchs, Tom A Gardiner, David A Simpson, Alan W Stitt BMC Medical Genomics 2010, 3:18 (13 May 2010)
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| PubMed | Cited on BioMed Central
| F1000
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7.
8757 Accesses
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The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis
Adam I Riker, Steven A Enkemann, Oystein Fodstad, Suhu Liu, Suping Ren, Christopher Morris, Yaguang Xi, Paul Howell, Brandon Metge, Rajeev S Samant, Lalita A Shevde, Wenbin Li, Steven Eschrich, Adil Daud, Jingfang Ju, Jaime Matta BMC Medical Genomics 2008, 1:13 (28 April 2008)
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8.
8461 Accesses
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The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice
Nicole JW de Wit, Hanneke Bosch-Vermeulen, Philip J de Groot, Guido JEJ Hooiveld, Mechteld Bromhaar, Jenny Jansen, Michael Müller, Roelof van der Meer BMC Medical Genomics 2008, 1:14 (6 May 2008)
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| PubMed | Cited on BioMed Central
| F1000
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9.
8226 Accesses
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Genotyping panel for assessing response to cancer chemotherapy
Zunyan Dai, Audrey C Papp, Danxin Wang, Heather Hampel, Wolfgang Sadee BMC Medical Genomics 2008, 1:24 (11 June 2008)
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10.
8121 Accesses
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Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses
Anat Zvi, Naomi Ariel, John Fulkerson, Jerald C Sadoff, Avigdor Shafferman BMC Medical Genomics 2008, 1:18 (28 May 2008)
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11.
7669 Accesses
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Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer
Meng Li, Curt Balch, John S Montgomery, Mikyoung Jeong, Jae Chung, Pearlly Yan, Tim HM Huang, Sun Kim, Kenneth P Nephew BMC Medical Genomics 2009, 2:34 (8 June 2009)
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12.
7485 Accesses
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Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer
Timothy J McDonnell, Nikhil S Chari, Jeong Cho-Vega, Patricia Troncoso, Xuemei Wang, Carlos E Bueso-Ramos, Kevin Coombes, Shawn Brisbay, Remigio Lopez, George Prendergast, Christopher Logothetis, Kim-Anh Do BMC Medical Genomics 2008, 1:1 (31 January 2008)
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| PubMed | Cited on BioMed Central
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Editor’s summary
Tissue microarray analysis of prostate cancer demonstrates strong correlations between the expression of several apoptotic or cell cycle proteins and tumor grade, which may allow the prediction of clinically aggressive behavior.
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13.
7445 Accesses
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Worldwide population differentiation at disease-associated SNPs
Sean Myles, Dan Davison, Jeffrey Barrett, Mark Stoneking, Nic Timpson BMC Medical Genomics 2008, 1:22 (4 June 2008)
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14.
7416 Accesses
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A gene signature for post-infectious chronic fatigue syndrome
John W Gow, Suzanne Hagan, Pawel Herzyk, Celia Cannon, Peter O Behan, Abhijit Chaudhuri BMC Medical Genomics 2009, 2:38 (25 June 2009)
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15.
7189 Accesses
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Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs
Perry Evans, William Dampier, Lyle Ungar, Aydin Tozeren BMC Medical Genomics 2009, 2:27 (18 May 2009)
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16.
7133 Accesses
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MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes
Blanca M Herrera, Helen E Lockstone, Jennifer M Taylor, Quin F Wills, Pamela J Kaisaki, Amy Barrett, Carme Camps, Christina Fernandez, Jiannis Ragoussis, Dominique Gauguier, Mark I McCarthy, Cecilia M Lindgren BMC Medical Genomics 2009, 2:54 (18 August 2009)
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Editor’s summary
Combining global microRNA and mRNA expression data indicates MiR-125a is over-expressed in the liver of hyperglycaemic rats and is a putative modulator of glucose and lipid metabolism in a rat model of type 2 diabetes.
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17.
6938 Accesses
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A high confidence, manually validated human blood plasma protein reference set
Susann Schenk, Gary J Schoenhals, Gustavo de Souza, Matthias Mann BMC Medical Genomics 2008, 1:41 (15 September 2008)
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18.
6849 Accesses
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Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples
Serban Nacu, Wenlin Yuan, Zhengyan Kan, Deepali Bhatt, Celina Rivers, Jeremy Stinson, Brock A Peters, Zora Modrusan, Kenneth Jung, Somasekar Seshagiri, Thomas D Wu BMC Medical Genomics 2011, 4:11 (24 January 2011)
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19.
6818 Accesses
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The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies
Catherine A McCarty, Rex L Chisholm, Christopher G Chute, Iftikhar J Kullo, Gail P Jarvik, Eric B Larson, Rongling Li, Daniel R Masys, Marylyn D Ritchie, Dan M Roden, Jeffery P Struewing, Wendy A Wolf, the eMERGE Team BMC Medical Genomics 2011, 4:13 (26 January 2011)
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20.
6799 Accesses
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Detailed transcriptome atlas of the pancreatic beta cell
Burak Kutlu, David Burdick, David Baxter, Joanne Rasschaert, Daisy Flamez, Decio L Eizirik, Nils Welsh, Nathan Goodman, Leroy Hood BMC Medical Genomics 2009, 2:3 (15 January 2009)
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21.
6767 Accesses
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Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis
Jennifer S Guimbellot, Stephen W Erickson, Tapan Mehta, Hui Wen, Grier P Page, Eric J Sorscher, Jeong S Hong BMC Medical Genomics 2009, 2:15 (25 March 2009)
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22.
6750 Accesses
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Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets
Bertalan Mesko, Szilard Poliska1, Andrea Szegedi, Zoltan Szekanecz, Karoly Palatka, Maria Papp, Laszlo Nagy BMC Medical Genomics 2010, 3:15 (5 May 2010)
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23.
6458 Accesses
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Impact of RNA degradation on gene expression profiling
Lennart Opitz, Gabriela Salinas-Riester, Marian Grade, Klaus Jung, Peter Jo, Georg Emons, B Michael Ghadimi, Tim Beißbarth, Jochen Gaedcke BMC Medical Genomics 2010, 3:36 (9 August 2010)
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24.
6431 Accesses
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Targeted high throughput sequencing in clinical cancer Settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity
Martin Kerick, Melanie Isau, Bernd Timmermann, Holger Sültmann, Ralf Herwig, Sylvia Krobitsch, Georg Schaefer, Irmgard Verdorfer, Georg Bartsch, Helmut Klocker, Hans Lehrach, Michal R Schweiger BMC Medical Genomics 2011, 4:68 (29 September 2011)
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25.
6236 Accesses
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Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes
Ji-Hoon Cho, Richard Gelinas, Kai Wang, Alton Etheridge, Melissa G Piper, Kara Batte, Duaa Dakhlallah, Jennifer Price, Dan Bornman, Shile Zhang, Clay Marsh, David Galas BMC Medical Genomics 2011, 4:8 (17 January 2011)
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Editor’s summary
Integrating mRNA and microRNA profiles of interstitial lung diseases using a systems biology approach highlights the network perturbations and key microRNAs involved in the progression of the diseases.
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26.
6221 Accesses
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Global analysis of DNA methylation in early-stage liver fibrosis
Yoko Komatsu, Tsuyoshi Waku, Naoya Iwasaki, Wakana Ono, Chie Yamaguchi, Junn Yanagisawa BMC Medical Genomics 2012, 5:5 (27 January 2012)
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27.
6075 Accesses
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Expression profiling with RNA from formalin-fixed, paraffin-embedded material
Andrea Oberli, Vlad Popovici, Mauro Delorenzi, Anna Baltzer, Janine Antonov, Sybille Matthey, Stefan Aebi, Hans Altermatt, Rolf Jaggi BMC Medical Genomics 2008, 1:9 (19 April 2008)
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28.
5995 Accesses
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Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer
Sherene Loi, Christos Sotiriou, Benjamin Haibe-Kains, Francoise Lallemand, Nelly M Conus, Martine J Piccart, Terence P Speed, Grant A McArthur BMC Medical Genomics 2009, 2:37 (24 June 2009)
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Editor’s summary
Activation of growth factor (GF) signalling contributes to the tamoxifen-insensitive estrogen receptor-positive breast cancer phenotype independent of human epidermal growth factor receptor (HER2) gene expression, suggesting an alternative therapeutic target for this aggressive disease.
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29.
5908 Accesses
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A genome-wide DNA methylation study in colorectal carcinoma
Muhammad G Kibriya, Maruf Raza, Farzana Jasmine, Shantanu Roy, Rachelle Paul-Brutus, Ronald Rahaman, Charlotte Dodsworth, Muhammad Rakibuz-Zaman, Mohammed Kamal, Habibul Ahsan BMC Medical Genomics 2011, 4:50 (23 June 2011)
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30.
5728 Accesses
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The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma
Cinzia Di Pietro, Marco Ragusa, Davide Barbagallo, Laura R Duro, Maria R Guglielmino, Alessandra Majorana, Rosario Angelica, Marina Scalia, Luisa Statello, Loredana Salito, Luisa Tomasello, Salvo Pernagallo, Salvo Valenti, Vito D'Agostino, Patrizio Triberio, Igor Tandurella, Giuseppe A Palumbo, Piera La Cava, Viviana Cafiso, Taschia Bertuccio, Maria Santagati, Giovanni Li Destri, Salvatore Lanzafame, Francesco Di Raimondo, Stefania Stefani, Bud Mishra, Michele Purrello BMC Medical Genomics 2009, 2:20 (30 April 2009)
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31.
5726 Accesses
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Robust SNP genotyping by multiplex PCR and arrayed primer extension
Mohua Podder, Jian Ruan, Ben W Tripp, Zane E Chu, Scott J Tebbutt BMC Medical Genomics 2008, 1:5 (31 January 2008)
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32.
5682 Accesses
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Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol
Zhiqiang Pan, Ameeta K Agarwal, Tao Xu, Qin Feng, Scott R Baerson, Stephen O Duke, Agnes M Rimando BMC Medical Genomics 2008, 1:7 (20 March 2008)
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33.
5662 Accesses
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Diurnal variation of the human adipose transcriptome and the link to metabolic disease
Andrey Loboda, Walter K Kraft, Bernard Fine, Jeffrey Joseph, Michael Nebozhyn, Chunsheng Zhang, Yudong He, Xia Yang, Christopher Wright, Mark Morris, Ira Chalikonda, Mark Ferguson, Valur Emilsson, Amy Leonardson, John Lamb, Hongyue Dai, Eric Schadt, Howard E Greenberg, Pek Lum BMC Medical Genomics 2009, 2:7 (9 February 2009)
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34.
5643 Accesses
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Complex nature of SNP genotype effects on gene expression in primary human leucocytes
Graham A Heap, Gosia Trynka, Ritsert C Jansen, Marcel Bruinenberg, Morris A Swertz, Lotte C Dinesen, Karen A Hunt, Cisca Wijmenga, David A vanHeel, Lude Franke BMC Medical Genomics 2009, 2:1 (7 January 2009)
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35.
5475 Accesses
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PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
Roy RL Bastien, Álvaro Rodríguez-Lescure, Mark TW Ebbert, Aleix Prat, Blanca Munárriz, Leslie Rowe, Patricia Miller, Manuel Ruiz-Borrego, Daniel Anderson, Bradley Lyons, Isabel Álvarez, Tracy Dowell, David Wall, Miguel Seguí, Lee Barley, Kenneth M Boucher, Emilio Alba, Lisa Pappas, Carole A Davis, Ignacio Aranda, Christiane Fauron, Inge J Stijleman, José Palacios, Antonio Antón, Eva Carrasco, Rosalía Caballero, Matthew J Ellis, Torsten O Nielsen, Charles M Perou, Mark Astill, Philip S Bernard, Miguel Martín et al.
BMC Medical Genomics 2012, 5:44 (4 October 2012)
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36.
5409 Accesses
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Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia
Laura W Harris, Helen E Lockstone, Phillipp Khaitovich, Cynthia Weickert, Maree J Webster, Sabine Bahn BMC Medical Genomics 2009, 2:28 (20 May 2009)
Abstract | Full text | PDF
| PubMed | Cited on BioMed Central
| F1000 Biology
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37.
5395 Accesses
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Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age
Yohan Lee, Adrienne C Scheck, Timothy F Cloughesy, Albert Lai, Jun Dong, Haumith K Farooqi, Linda M Liau, Steve Horvath, Paul S Mischel, Stanley F Nelson BMC Medical Genomics 2008, 1:52 (21 October 2008)
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Editor’s summary
Younger patients with the most serious grade of brain tumor, glioblastoma multiforme, may survive longer because they are more likely to present with the gene signature of the proneural subtype relative to more common and aggressive forms.
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38.
5383 Accesses
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A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
Richard Abraham, Valentina Moskvina, Rebecca Sims, Paul Hollingworth, Angharad Morgan, Lyudmila Georgieva, Kimberley Dowzell, Sven Cichon, Axel M Hillmer, Michael C O'Donovan, Julie Williams, Michael J Owen, George Kirov BMC Medical Genomics 2008, 1:44 (29 September 2008)
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39.
5311 Accesses
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EMT is the dominant program in human colon cancer
Andre Loboda, Michael V Nebozhyn, James W Watters, Carolyne A Buser, Peter Shaw, Pearl S Huang, Laura Van't Veer, Rob AEM Tollenaar, David B Jackson, Deepak Agrawal, Hongyue Dai, Timothy J Yeatman BMC Medical Genomics 2011, 4:9 (20 January 2011)
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Editor’s summary
The intrinsic first principal component (PC1) signature, tightly correlated with epithelial-mesenchymal transition (EMT), is highly prognostic for colon cancer recurrence and may also aid in sub classifying multiple types of cancer and their novel therapeutics.
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40.
5310 Accesses
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An expression meta-analysis of predicted microRNA targets identifies a diagnostic signature for lung cancer
Yu Liang BMC Medical Genomics 2008, 1:61 (16 December 2008)
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41.
5291 Accesses
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Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information
Yonqing Zhang, Supriyo De, John R Garner, Kirstin Smith, S Alex Wang, Kevin G Becker BMC Medical Genomics 2010, 3:1 (21 January 2010)
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| PubMed | Cited on BioMed Central
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Editor’s summary
Systematic comparison of human genetic association data with genetically-determined phenotypic mouse data identifies gene sets which group into disease- and phenotypically-relevant groups at both a coarse and fine level based on gene sharing.
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42.
5240 Accesses
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Discovery of DNA methylation markers in cervical cancer using relaxation ranking
Maté Ongenaert, G Bea A Wisman, Haukeline H Volders, Alice J Koning, Ate Zee, Wim van Criekinge, Ed Schuuring BMC Medical Genomics 2008, 1:57 (24 November 2008)
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43.
5178 Accesses
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Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health
Wim Crielaard, Egija Zaura, Annemarie A Schuller, Susan M Huse, Roy C Montijn, Bart JF Keijser BMC Medical Genomics 2011, 4:22 (4 March 2011)
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44.
5169 Accesses
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Molecular sampling of prostate cancer: a dilemma for predicting disease progression
Andrea Sboner, Francesca Demichelis, Stefano Calza, Yudi Pawitan, Sunita R Setlur, Yujin Hoshida, Sven Perner, Hans-Olov Adami, Katja Fall, Lorelei A Mucci, Philip W Kantoff, Meir Stampfer, Swen-Olof Andersson, Eberhard Varenhorst, Jan-Erik Johansson, Mark B Gerstein, Todd R Golub, Mark A Rubin, Ove Andrén BMC Medical Genomics 2010, 3:8 (16 March 2010)
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45.
5151 Accesses
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2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting
Freek G Bouwman, Baukje de Roos, Isabel Rubio-Aliaga, L Katie Crosley, Susan J Duthie, Claus Mayer, Graham Horgan, Abigael C Polley, Carolin Heim, Susan LM Coort, Chris T Evelo, Francis Mulholland, Ian T Johnson, Ruan M Elliott, Hannelore Daniel, Edwin CM Mariman BMC Medical Genomics 2011, 4:24 (25 March 2011)
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46.
5112 Accesses
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Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes
Dominik Beck, Steve Ayers, Jianguo Wen, Miriam B Brandl, Tuan D Pham, Paul Webb, Chung-Che Chang, Xiaobo Zhou BMC Medical Genomics 2011, 4:19 (23 February 2011)
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47.
5110 Accesses
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PrognoScan: a new database for meta-analysis of the prognostic value of genes
Hideaki Mizuno, Kunio Kitada, Kenta Nakai, Akinori Sarai BMC Medical Genomics 2009, 2:18 (24 April 2009)
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48.
5101 Accesses
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Novel transcriptional profile in wrist muscles from cerebral palsy patients
Lucas R Smith, Eva Pontén, Yvette Hedström, Samuel R Ward, Henry G Chambers, Shankar Subramaniam, Richard L Lieber BMC Medical Genomics 2009, 2:44 (14 July 2009)
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49.
5077 Accesses
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Modeling microRNA-mRNA Interactions Using PLS Regression in Human Colon Cancer
Xiaohong Li, Ryan Gill, Nigel GF Cooper, Jae Yoo, Susmita Datta BMC Medical Genomics 2011, 4:44 (19 May 2011)
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50.
4992 Accesses
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Genotator: A disease-agnostic tool for genetic annotation of disease
Dennis P Wall, Rimma Pivovarov, Mark Tong, Jae-Yoon Jung, Vincent A Fusaro, Todd F DeLuca, Peter J Tonellato BMC Medical Genomics 2010, 3:50 (29 October 2010)
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