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  • Bronchial epithelial cells in Z-AATD COPD

    Bronchial epithelial cells (BECs) from patients with Z variant alpha-1 antitrypsin (Z-AAT) deficiency, express and secrete Z-AAT and its polymers, suggesting that these cells are involved in the pathogenesis of emphysema and BEC dysfunction.

    Respiratory Research 2014, 15:112
  • Evaluating the Y chromosomal timescale

    The Y-chromosome can be used for paternal demographic and lineage dating, however owing to naturally occuring mutations, results can be incaccurate. Looking into a solution for one of the biggest problems in Y-chromosome phylogenetic studies.

    Investigative Genetics 2014, 5:12
  • Image attributed to: Mitou et al. International Journal of Plant Genomics (CC-BY)

    Targeting autophagy in cancer

    Eileen White discusses how cancer cells use autophagy to survive in low nutrient conditions and how new drugs targeting this process can be used to treat cancer.

    Cancer & Metabolism 2014, 2:14
  • Histone marks: an alternative form of protection for sperm

    Repression of mobile genetic elements is essential for the survival of germ cells. A new pathway for silencing LINE-1 elements is described by Donal O'Carroll and colleagues.

    Epigenetics & Chromatin 2014, 7:24
  • Image attributed to: Wikipedia;ObwiedniaPeptydu

    Searching for cancer biomarkers

    Whole exome and whole genome sequencing has revealed specific mutations for various cancers, and so Eleftherios Diamandis suggests that the combination of genomics and proteomics may help to identify and develop clinically useful biomarkers.

    BMC Medicine 2014, 12:156
  • Image attributed to: Figure 7

    BMP7's role in branching

    Transition from the initial wide branching urinary collecting duct tree to narrower later branching is dependent on the proximity of other branch tips with bone morphogenetic protein 7 (BMP7) acting as a repelling molecule in this process.

    BMC Developmental Biology 2014, 14:35
  • Image attributed to: Delwart; doi:10.1371/journal.ppat.1003146

    The human virome – or a virome for each human?

    George Weinstock and colleagues analyze the double-stranded DNA virus genomes lurking in the wealth of data generated by the Human Microbiome Project, across multiple body habitats, individuals and timepoints.

    BMC Biology 2014, 12:71
  • Image attributed to: Wikipedia

    Liver fat score is best to predict NAFLD 

    In a comparison of four non-alcoholic fatty-liver disease (NAFLD) prediction scores, liver fat score (LFS) is the most robust in identifying NAFLD in an American population, suggesting LFS could be used to predict liver-related mortality.

    BMC Medicine 2014, 12:154
  • Image attributed to: Stefan Laube, Public Domain

    Slothful trends in evolution

    While existing sloth species have relatively small body sizes, a phylogenetic analysis that includes fossil species suggests this is unrepresentative of long-term evolutionary trends in this group which were towards larger and larger body sizes.

    BMC Evolutionary Biology 2014, 14:184
  • Image attributed to: Wikimedia commons (ComputerHotline)

    ​Antibodies linked to P. vivax infection

    Evidence from a systematic review and meta-analysis suggests that several specific antibodies are associated with Plasmodium vivax malaria infection and protective immunity, suggesting these antibodies could be used to inform vaccine design.

    BMC Medicine 2014, 12:150
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