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  • Seizures in an immunocompromised youth

    Immunocompromised patients are at higher risk of contracting tuberculosis with atypical presentations. A 17 year-old man presented with focal fits progressing to epilepsia partialis continua. Mycobacterium tuberculosis was detected in the cerebrospinal fluid and successfully treated.

    Journal of Medical Case Reports 2015, 9:184
  • Predicting chromatin compartments

    A method for predicting a sequence’s localization in the A or B compartment of the nucleus based on chromatin data

    Genome Biology 2015, 16:180
  • Towards personalised radiation therapy

    Part of a series on bioinformatics and systems biology in radiation oncology, this review looks at the promise of next-generation sequencing for developing personalised cancer treatment strategies.

    Radiation Oncology 2015, 10:183
  • Image attributed to: flickr; doviende

    ADHD linked to mathematical ability

    In a systematic review, the inattentive component of attention deficit/hyperactivity disorder (ADHD) has a stronger negative association with mathematical ability than the hyperactive component, highlighting that ADHD domains could have differential etiology.

    BMC Medicine 2015, 13:204
  • Image attributed to: From Fig 1 Pelletier and colleagues

    DNA-PK inhibition boosts Cas9-mediated HDR

    Transient pharmacological inhibition of DNA-PKcs can stimulate homology-directed repair following Cas9-mediated induction of a double strand break, and is expected to reduce the downstream workload.

    Genome Medicine 2015, 7:93
  • Image attributed to: Figure 6

    3D plant cell culture

    A new technique borrows from biomedical engineering to study plant cells in culture conditions that mimic tissue scaffolds, allowing for a more physiologically relevant way to explore cell-environment interactions.

    BMC Plant Biology 2015, 15:211
  • In-nucleus ligation Hi-C

    A comparison of in-nucleus and in-solution ligation protocols for Hi-C finds that the former gives much more consistent results

    Genome Biology 2015, 16:175
  • RF associated with higher RA disease scores

    The presence of rheumatoid factor (RF) has a clear association with high levels of disease activity in rheumatoid arthritis (RA) patients whereas autoantibodies against citrullinated proteins (APCA), the characteristic marker, does not.

    Arthritis Research & Therapy 2015, 17:229
  • Barley domestication

    Robin Allaby discusses the origins of barley, and what this means for our understanding of the evolution of domesticated crops

    Genome Biology 2015, 16:176
  • Astrocytes in the sleeping and awake brain

    Does the state of the brain - whether asleep, awake, or sleep-deprived - affect astrocytes (or vice versa)? Profiling of ribosome-associated mRNAs identifies changes in gene expression, while 3-d imaging at nanometer resolution reveals a retraction of astrocytic processes from neural synapses during sleep.

    BMC Biology 2015, 13:66
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    This is the first open access journal in the field of travel medicine and the first journal to focus on intersecting topics in tropical diseases, travel medicine and vaccines.  Considering the increased mobility of world populations and increasing globalization of world economies, the journal meets the growing need for the dissemination of research with strong implications for world health and medicine.

    Read more about it in the editorial 'The local importance of global infectious diseases'.

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    Chinese Neurosurgical Journal has now fully launched

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    The Editor-in-Chief Jizong Zhao is a leading expert in neurosurgery in China and also an academician of Chinese Academy of Sciences.

    Click here to find out why you should publish in this journal.

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