Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis
BMC Medicine 2014, 12:211 (27 November 2014)
Oral testosterone replacement therapy (TRT) leads to significant cardiovascular (CV) risk, whereas injected or transdermal TRT do not, which could be due to the different routes of administration, which might affect serum dihydrotestosterone.
The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials
BMC Medicine 2013, 11:57 (28 February 2013)
According to a meta-analysis, treatment with statins, a drug commonly prescribed to patients at risk of cardiovascular disease, can reduce testosterone levels in both men and women, although the cause for this needs to be determined by further studies.