Stroke, multimorbidity and polypharmacy in a nationally representative sample of 1,424,378 patients in Scotland: implications for treatment burden
BMC Medicine 2014, 12:151 (3 October 2014)
Multimorbidity and polypharmacy are more common in those with history of stroke compared with those without, indicating that guidelines should place greater emphasis on the management of multimorbidity in these patients.
The epidemiology of silent brain infarction: a systematic review of population-based cohorts
BMC Medicine 2014, 12:119 (9 July 2014)
Evidence from a systematic review suggests that silent brain infarctions (SBI), cerebral infarctions without clinical symptoms, are common in the elderly, indicating that further research to understand the pathophysiology of SBI is warranted.
Formal and informal prediction of recurrent stroke and myocardial infarction after stroke: a systematic review and evaluation of clinical prediction models in a new cohort
BMC Medicine 2014, 12:58 (4 April 2014)
Evidence from a systematic review and meta-analysis suggests current predictive models discriminate poorly between patients with and without recurrent stroke or myocardial infarction, and resolving the methodological limitations could improve predictive ability.
Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study
BMC Medicine 2014, 12:53 (25 March 2014)
Ovarian cancer patients have an increased risk of developing ischemic stroke compared with healthy controls, suggesting that stroke surveillance and prevention strategies should be considered in these patients.
Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
BMC Medicine 2012, 10:158 (6 December 2012)
A computer model on heart disease and stroke predicts mortality and cardiovascular disease events after a period of 5 years and an extended follow-up of 13 years, and additionally shows external validation in a different cohort of patients.
Stroke genetics: prospects for personalized medicine
BMC Medicine 2012, 10:113 (27 September 2012)
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Hugh Markus reviews the latest developments in stroke genetics, highlighting how the variants identified confer only a small risk of disease, and describes how pharmacogenomic approaches can be applied for patient-tailored therapy.
A cluster randomized trial to assess the effect of clinical pathways for patients with stroke: results of the clinical pathways for effective and appropriate care study
BMC Medicine 2012, 10:71 (10 July 2012)
The Clinical Pathways for Effective and Appropriate Care (CPEAC) trial shows that ischemic stroke patients have lower 7-day mortality, and are more likely to return to daily life, following structured care treatment compared with usual care.