β cells keep bad epigenetic memories of palmitate
BMC Medicine 2014, 12:104 (23 June 2014)
Delphine Fradin and Pierre Bougnères discuss the limitations of a study revealing palmitate-induced epigenetic alterations in pancreatic cells, but emphasize that the findings pave the way for future research into obesity-induced metabolic changes.
Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets
BMC Medicine 2014, 12:103 (23 June 2014)
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Exposing pancreatic islet cells to the free fatty acid palmitate results in differential gene expression and epigenetic modifications, which may influence type 2 diabetes risk through impaired insulin secretion in these treated cells.