EGFR-directed antibodies increase the risk of severe infection in cancer patients
BMC Medicine 2015, 13:37 (20 February 2015)
Barbara Burtness and Mehmet Altan comment on research showing an increased risk of severe infection in cancer patients on EGFR-directed antibody therapy, highlighting that dose modification strategies could be developed to reduce infection risk.
Time-to-infection by Plasmodium falciparum is largely determined by random factors
BMC Medicine 2015, 13:19 (30 January 2015)
In a mathematical model, the timing of infection by Plasmodium falciparum malaria mostly depends on random factors, suggesting that parasite growth rate could be more useful than time-to-infection measures in estimating protective immunity.
Could low grade bacterial infection contribute to low back pain? A systematic review
BMC Medicine 2015, 13:13 (22 January 2015)
Evidence from a systematic review suggests the presence of bacteria in spinal discs could be associated with low back pain and disc herniation, but more research is needed to determine whether low-grade infection contributes to chronic pain.
Incidence and risk of severe infections associated with anti-epidermal growth factor receptor monoclonal antibodies in cancer patients: a systematic review and meta-analysis
BMC Medicine 2014, 12:203 (5 November 2014)
Evidence from a meta-analysis suggests that treatment with anti-epidermal growth factor receptor (EGFR) antibodies increases the chance of developing severe infection in cancer patients, highlighting that clinicians should be aware of infection risk.
Predicting outcome from dengue
BMC Medicine 2014, 12:147 (4 September 2014)
Dengue fever is a mild illness in most people but some develop fatal complications; Sophie Yacoub and Bridget Wills outline the risk factors associated with severe disease, and discuss biomarkers for risk prediction and early intervention.
The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life
BMC Medicine 2014, 12:120 (17 July 2014)
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An increased ratio of blood monocytes to lymphocytes (ML) in South African infants aged 3 to 4 months is associated with tuberculosis (TB) risk in the first two years of life, suggesting the ML ratio may help identify at-risk infants.
Impact of early daycare on healthcare resource use related to upper respiratory tract infections during childhood: prospective WHISTLER cohort study
van der Ent,
BMC Medicine 2014, 12:107 (26 June 2014)
Children attending daycare in the first year of life have greater risk of upper respiratory tract infections than non-attendees, suggesting that improved prevention strategies are required to reduce infection rates in daycare facilities.
Classification of healthcare-associated infection: a systematic review 10 years after the first proposal
BMC Medicine 2014, 12:40 (6 March 2014)
Evidence from a systematic review suggests that the definition of healthcare-associated infection (HCAI) proposed in 2002 is widely used, and future revisions of the definition should take invasive procedures and hospitalization into account.
Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review
BMC Medicine 2014, 12:31 (19 February 2014)
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In a systematic review, children with recent or acute malaria are at risk of invasive bacterial infection resulting in a higher rate of mortality, suggesting that better understanding of this association could improve treatment strategies.