A proposed panel of biomarkers of healthy ageing
BMC Medicine 2015, 13:222 (15 September 2015)
Jose Lara and colleagues propose a panel of biomarkers to assess healthy aging, addressing major areas of declining function, which may be useful for future research designed to improve cognitive and physical function during the aging process.
Frailty: a tale of two concepts
BMC Medicine 2015, 13:185 (11 August 2015)
Jeremy Walston and Karen Bandeen-Roche comment on recent research identifying a biomarker-based index of frailty, highlighting that refinement of the score to focus on aging-related biological changes could provide further insights into frailty prevention.
Age-related frailty and its association with biological markers of ageing
BMC Medicine 2015, 13:161 (13 July 2015)
A frailty index combining 40 blood biomarkers is a better predictor of mortality in the very old than any marker alone, and is associated with improved prediction when added to the FI-CD clinical index, indicating that frailty is a systemic process.
Prevalence, risk factors and disability associated with fall-related injury in older adults in low- and middle-incomecountries: results from the WHO Study on global AGEing and adult health (SAGE)
BMC Medicine 2015, 13:147 (23 June 2015)
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Big Risks: the challenges...
The prevalence of fall-related injuries ranges from 1% to 6.6% in low- and middle-income countries (LMICs), and those with depression, sleeping problems and comorbidities are at greater risk, providing insights into the risk factors for falls.
No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over
BMC Medicine 2015, 13:78 (9 April 2015)
In a randomized controlled trial, antihypertensive treatments are effective for both frailer and fitter older adults, with no evidence of an interaction between frailty and therapy efficacy, suggesting frail people are likely to benefit from treatment.
Major dietary patterns and risk of frailty in older adults: a prospective cohort study
BMC Medicine 2015, 13:11 (20 January 2015)
In older adults, a prudent diet containing olive oil and vegetables is linked to lower risk of frailty whereas a Western diet is associated with frailty components, highlighting the need for trials to determine whether diet can protect against frailty.
Association of behaviour change techniques with effectiveness of dietary interventions among adults of retirement age: a systematic review and meta-analysis of randomised controlled trials
BMC Medicine 2014, 12:177 (7 October 2014)
A systematic review and meta-analysis identifies behaviour change techniques (BCTs) linked to effectiveness of dietary interventions, such as increased fruit and vegatable consumption, in older adults, suggesting that BCTs such as ‘goal setting’ lead to better diet success.
The effect of a pre- and postoperative orthogeriatric service on cognitive function in patients with hip fracture: randomized controlled trial (Oslo Orthogeriatric Trial)
BMC Medicine 2014, 12:63 (15 April 2014)
In a randomized trial, perioperative orthogeriatric care does not reduce delirium and cognitive decline in hip fracture patients, but has a positive effect on mobility, highlighting a need for integration of orthopedic and geriatric services.
Whole home exercise intervention for depression in older care home residents (the OPERA study): a process evaluation
BMC Medicine 2014, 12:1 (3 January 2014)
A process evaluation of the OPERA trial suggests that home exercise does not reduce depression in care home residents due to physical and mental frailty of the residents, making it difficult to carry out sufficiently intense exercise.
A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial
BMC Medicine 2013, 11:65 (11 March 2013)
In a randomized trial, frail older people on a 12-month multifactorial interdisciplinary program show reduced frailty and improved mobility compared with the group on usual care, indicating that the intervention can be used to treat frailty.
Geriatric consultation services-are wards more effective than teams?
BMC Medicine 2013, 11:49 (22 February 2013)
Although comprehensive geriatric assessment (CGA) by mobile teams can improve outcomes for mortality in frail older patients, Ian Cameron & Susan Kurrle argue that ward-based CGA is more effective for streaming patients that need complex treatment.
Making mobility-related disability better: a complex response to a complex problem
BMC Medicine 2012, 10:121 (15 October 2012)
Mobility-related disability in frail older people has been found to be reduced in a recent clinical trial; Kenneth Rockwood comments on understanding the complex needs of these individuals to provide effective treatment and a better quality of life.