Why do hypertensive patients of African ancestry respond better to calcium
blockers and diuretics than to ACE inhibitors and β-adrenergic blockers? A
BMC Medicine 2013, 11:141 (30 May 2013)
Evidence from a systematic review shows pharmacokinetics, plasma renin and genetic polymorphisms are not associated with antihypertensive drug therapy, but African ancestry is the best predictor of individual responses to these drugs.
Impact of diuretic therapy-associated electrolyte disorders present on admission to the emergency department: a cross-sectional analysis
BMC Medicine 2013, 11:83 (27 March 2013)
Patients on diuretics have a high prevalence of electrolyte disorders on admission to the emergency room and diuretic therapy is associated with in-hospital mortality, suggesting alternative treatment could be considered for at-risk patients.