Is dementia research ready for big data approaches?
BMC Medicine 2015, 13:145 (22 June 2015)
Although Big Data provides exciting avenues for medical research, Martin Hofmann-Apitius highlights that with regard to complex diseases such as dementia, caution is needed to assess how Big Data approaches can reliably inform dementia research.
Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98
BMC Medicine 2014, 12:164 (30 September 2014)
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Strict adherence to the DSM-5 criteria results in fewer delirium diagnoses than when DSM-IV are used, whereas applying ‘relaxed’ DSM-5 criteria identifies a comparable number of cases, supporting a more relaxed approach for delirium diagnosis.
Potential repurposing of oncology drugs for the treatment of Alzheimer's disease
BMC Medicine 2013, 11:82 (26 March 2013)
There are currently no therapies that target the underlying cause of Alzheimer’s disease (AD); Wataru Araki comments on research showing carmustine reduces amyloid plaques in a mouse model, and discusses the potential of oncology drugs for AD treatment.