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		Research article Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz BMC Medicine 2013, 11:109 (23 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum biomarkers identify neurofibromatosis type 1 patients at risk of malignant peripheral nerve sheath tumor development, and other markers discriminate between these patients and healthy controls, making them useful as diagnostic tools.
		Research article Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials Lin Xu, Guy Freeman, Benjamin J Cowling, C Schooling BMC Medicine 2013, 11:108 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Evidence from a systematic review and meta-analysis shows that testosterone therapy increases cardiovascular-related events in men, and the risk of this therapy is mainly evident in trials not funded by the pharmaceutical industry.
		Correspondence Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth, T West BMC Medicine 2013, 11:107 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shevin Jacob et al. discuss the ‘Integrated Management of Adolescent and Adult Illness District Clinician Manual’ sepsis management guidelines for resource-limited settings, highlighting the importance of ensuring sepsis research is undertaken in such locations.
		Research article Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang, Ker-Chau Li BMC Medicine 2013, 11:106 (16 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A unique gene signature correlates with chemotherapy sensitivity in a panel of cell lines and predicts drug response and survival in patients with lung and breast cancer, so could be used in the clinic in a personalized approach to cancer treatment.
		Research article Caregivers’ understanding of dementia predicts patients’ comfort at death: a prospective observational study Jenny T van der Steen, Bregje D Onwuteaka-Philipsen, Dirk L Knol, Miel W Ribbe, Luc Deliens BMC Medicine 2013, 11:105 (11 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caregivers’ awareness of dementia as a terminal disease is associated with better patient comfort, suggesting that educating the families of dementia sufferers is important to ensure appropriate planning is undertaken to improve the care of these patients.
		Minireview Advances in bladder cancer imaging Shaista Hafeez, Robert Huddart BMC Medicine 2013, 11:104 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shaista Hafeez and Robert Huddart discuss recent advances in bladder cancer imaging and review progress in functional imaging techniques which, upon further development and validation, may lead to tumor mapping and personalized patient therapies.
		Research article ‘You can’t just hit a button’: an ethnographic study of strategies to repurpose data from advanced clinical information systems for clinical process improvement Cecily Morrison, Matthew Jones, Rachel Jones, Alain Vuylsteke BMC Medicine 2013, 11:103 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Clinical information systems (CIS) are used in current healthcare policies to improve clinical processes; new evidence shows that redistribution of extra work, sufficient time, financial support and motivation are needed to deliver CIS efficiently in ICU.
		Research article Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb BMC Medicine 2013, 11:102 (9 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Surgeons show higher use of cognitive or mood enhancing drugs when surveyed with a higher level of anonymity and confidentiality; this drug use is associated with workload and stress suggesting the need for medical education on coping strategies.
		Research article Slow CCL2-dependent translocation of biopersistent particles from muscle to brain Zakir Khan, Christophe Combadière, François-Jérôme Authier, Valérie Itier, François Lux, Christopher Exley, Meriem Mahrouf-Yorgov, Xavier Decrouy, Philippe Moretto, Olivier Tillement, Romain K Gherardi, Josette Cadusseau BMC Medicine 2013, 11:99 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vaccine-derived aluminium and alum-particle fluorescent surrogates are well tolerated in mice, but are transported via monocyte lineage cells from muscle to the brain and spleen, where they accumulate, so higher doses of the adjuvant may be unsafe.
		Research article Anti-ribosomal P protein IgG autoantibodies in patients with systemic lupus erythematosus: diagnostic performance and clinical profile Diana Carmona-Fernandes, Maria Santos, Helena Canhão, João Fonseca BMC Medicine 2013, 11:98 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Anti-ribosomal P antibodies (anti-Rib-P) can identify patients with systemic lupus erythematosus (SLE) with high specificity and positive predictive value, indicating that these antibodies could be used in the clinic to improve accuracy of SLE diagnosis.
		Research article Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies Sreeram V Ramagopalan, Raph Goldacre, Andrew Skingsley, Chris Conlon, Michael J Goldacre BMC Medicine 2013, 11:97 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An analysis of hospital admissions and death certificates across England reveals the risk of tuberculosis (TB) is significantly increased in patients with immune-mediated diseases, highlighting the need for TB screening in these patients.
		Review Phosphodiesterase 4-targeted treatments for autoimmune diseases Neal Kumar, Ari M Goldminz, Noori Kim, Alice B Gottlieb BMC Medicine 2013, 11:96 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Phosphodiesterase (PDE) 4-targeted therapies are a promising option to treat a range of autoimmune diseases; Alice Gottlieb and colleagues review the development of PDE4 inhibitors for chronic conditions and discuss recent clinical trial data.
		Review Renal involvement in autoimmune connective tissue diseases Andreas Kronbichler, Gert Mayer BMC Medicine 2013, 11:95 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Andreas Kronbichler and Gert Mayer discuss renal impairment in autoimmune connective tissue disorders (CTDs) caused by underlying disease or drug reactions, and explain how physicians should take kidney function into account when treating CTDs.
		Commentary Age-related autoimmunity Zahava Vadasz, Tharwat Haj, Aharon Kessel, Elias Toubi BMC Medicine 2013, 11:94 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Elias Toubi and colleagues explore why autoimmunity is high in the elderly, and suggest that increased T-regulatory cells, which compensate for lower levels of thymic T-cells, may lead to a pro-inflammatory response, thereby increasing autoimmunity.
		Review Novel aspects of Sjögren’s syndrome in 2012 Angela Tincani, Laura Andreoli, Ilaria Cavazzana, Andrea Doria, Marta Favero, Maria-Giulia Fenini, Franco Franceschini, Andrea Lojacono, Giuseppe Nascimbeni, Amerigo Santoro, Francesco Semeraro, Paola Toniati, Yehuda Shoenfeld BMC Medicine 2013, 11:93 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Angela Tincani and colleagues review the latest developments in Sjogren's Syndrome research and therapies, and highlight a possible link between Vitamin D levels and development of the disease.
		Research article Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice Aviva Katzav, Nikolaos C Grigoriadis, Tania Ebert, Olga Touloumi, Miri Blank, Chaim G Pick, Yehuda Shoenfeld, Joab Chapman BMC Medicine 2013, 11:92 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Transgenic mice induced to develop antiphospholipid syndrome exhibit behavioral and cognitive dysfunction in correlation to the mutation allele load, indicating that the elevated circulating antibodies lead to neurodegeneration.
		Commentary Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy Takahisa Gono, Yasushi Kawaguchi, Hisashi Yamanaka BMC Medicine 2013, 11:91 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Takahisa Gono and colleagues comment on a study in mice in which 16/6 idiotype (Id) antibody impairs memory, and argue antibody cross-reactivity could explain the diverse clinical features in SLE with the autoantibody targets as potential therapies.
		Research article 16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus Shaye Kivity, Aviva Katzav, Maria Arango, Moran Landau-Rabi, Yaron Zafrir, Nancy Agmon-Levin, Miri Blank, Juan-Manuel Anaya, Edna Mozes, Joab Chapman, Yehuda Shoenfeld BMC Medicine 2013, 11:90 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Injection of 16/6 idiotype antibodies in brains of mice induces lupus symptoms, including cognitive impairment and brain inflammation, suggesting involvement of human anti-DNA antibody in cognitive decline and neuropsychiatric symptoms in lupus patients.
		Research article The thrombophilic network of autoantibodies in celiac disease Aaron Lerner, Nancy Agmon-Levin, Yinon Shapira, Boris Gilburd, Sandra Reuter, Idit Lavi, Yehuda Shoenfeld BMC Medicine 2013, 11:89 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Autoantibodies against thrombogenic factors are present at higher levels in children with celiac disease compared with healthy controls, suggesting these antibodies could be a therapeutic target for thrombophilia in celiac patients.
		Review Biologic therapy for autoimmune diseases: an update Ziv Rosman, Yehuda Shoenfeld, Gisele Zandman-Goddard BMC Medicine 2013, 11:88 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gisele Zandman-Goddard and colleagues review the advantages and drawbacks of biologic therapies for autoimmune disease, and discuss the importance of having a range of drugs available to treat patients with severe or resistant disease.
		Editorial Novel pebbles in the mosaic of autoimmunity Carlo Perricone, Nancy Agmon-Levin, Yehuda Shoenfeld BMC Medicine 2013, 11:101 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yehuda Shoenfeld and colleagues launch our new article collection, Autoimmunity, with an editorial discussing the evolution of autoimmunity research and emerging concepts in the pathology of autoimmune diseases.
		Review Requirements for innate immune pathways in environmentally induced autoimmunity Kenneth Pollard, Dwight H Kono BMC Medicine 2013, 11:100 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Kenneth Pollard and Dwight Kono review the immune pathways involved in idiopathic and environmentally induced autoimmunity, and highlight that further investigation is needed to understand the mechanistic pathways underlying this elusive condition.
		Research article Body mass index and incident coronary heart disease in women: a population-based prospective study Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F. Lucy Wright, Jane Green, Gillian Reeves, Valerie Beral, Million Women Study Collaborators BMC Medicine 2013, 11:87 (2 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Coronary heart disease increases with BMI in over 1 million women and this risk is not confounded by age, smoking, physical activity, alcohol consumption and status, suggesting population changes in BMI will reduce the burden of disease.
		Research article Calcium-deficiency assessment and biomarker identification by an integrated urinary metabonomics analysis Maoqing Wang, Xue Yang, Fan Wang, Ran Li, Hua Ning, Lixin Na, Yifan Huang, Yue Song, Liyan Liu, Hongzhi Pan, Qiuju Zhang, Lijun Fan, Ying Li, Changhao Sun BMC Medicine 2013, 11:86 (28 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A panel of protein biomarkers discriminates between calcium-deficient and non-deficient rats and two of these biomarkers, pseudouridine and citrate, correlate with calcium intake in humans, making them useful to screen for calcium deficiency.
		Review Novel approaches to minimize ventilator-induced lung injury Eddy Fan, Jesus Villar, Arthur S Slutsky BMC Medicine 2013, 11:85 (28 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Arthur Slutsky and colleagues review novel approaches to counteract ventilator-induced lung injury in patients with acute respiratory distress syndrome, discussing studies that minimize biotrauma and the underlying pathophysiology.

	All
		Research article Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz BMC Medicine 2013, 11:109 (23 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum biomarkers identify neurofibromatosis type 1 patients at risk of malignant peripheral nerve sheath tumor development, and other markers discriminate between these patients and healthy controls, making them useful as diagnostic tools.
		Research article Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials Lin Xu, Guy Freeman, Benjamin J Cowling, C Schooling BMC Medicine 2013, 11:108 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Evidence from a systematic review and meta-analysis shows that testosterone therapy increases cardiovascular-related events in men, and the risk of this therapy is mainly evident in trials not funded by the pharmaceutical industry.
		Correspondence Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth, T West BMC Medicine 2013, 11:107 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shevin Jacob et al. discuss the ‘Integrated Management of Adolescent and Adult Illness District Clinician Manual’ sepsis management guidelines for resource-limited settings, highlighting the importance of ensuring sepsis research is undertaken in such locations.
		Research article Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang, Ker-Chau Li BMC Medicine 2013, 11:106 (16 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A unique gene signature correlates with chemotherapy sensitivity in a panel of cell lines and predicts drug response and survival in patients with lung and breast cancer, so could be used in the clinic in a personalized approach to cancer treatment.
		Research article Caregivers’ understanding of dementia predicts patients’ comfort at death: a prospective observational study Jenny T van der Steen, Bregje D Onwuteaka-Philipsen, Dirk L Knol, Miel W Ribbe, Luc Deliens BMC Medicine 2013, 11:105 (11 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Caregivers’ awareness of dementia as a terminal disease is associated with better patient comfort, suggesting that educating the families of dementia sufferers is important to ensure appropriate planning is undertaken to improve the care of these patients.
		Minireview Advances in bladder cancer imaging Shaista Hafeez, Robert Huddart BMC Medicine 2013, 11:104 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Shaista Hafeez and Robert Huddart discuss recent advances in bladder cancer imaging and review progress in functional imaging techniques which, upon further development and validation, may lead to tumor mapping and personalized patient therapies.
		Research article ‘You can’t just hit a button’: an ethnographic study of strategies to repurpose data from advanced clinical information systems for clinical process improvement Cecily Morrison, Matthew Jones, Rachel Jones, Alain Vuylsteke BMC Medicine 2013, 11:103 (10 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Clinical information systems (CIS) are used in current healthcare policies to improve clinical processes; new evidence shows that redistribution of extra work, sufficient time, financial support and motivation are needed to deliver CIS efficiently in ICU.
		Research article Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb BMC Medicine 2013, 11:102 (9 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Surgeons show higher use of cognitive or mood enhancing drugs when surveyed with a higher level of anonymity and confidentiality; this drug use is associated with workload and stress suggesting the need for medical education on coping strategies.
		Research article Slow CCL2-dependent translocation of biopersistent particles from muscle to brain Zakir Khan, Christophe Combadière, François-Jérôme Authier, Valérie Itier, François Lux, Christopher Exley, Meriem Mahrouf-Yorgov, Xavier Decrouy, Philippe Moretto, Olivier Tillement, Romain K Gherardi, Josette Cadusseau BMC Medicine 2013, 11:99 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vaccine-derived aluminium and alum-particle fluorescent surrogates are well tolerated in mice, but are transported via monocyte lineage cells from muscle to the brain and spleen, where they accumulate, so higher doses of the adjuvant may be unsafe.
		Research article Anti-ribosomal P protein IgG autoantibodies in patients with systemic lupus erythematosus: diagnostic performance and clinical profile Diana Carmona-Fernandes, Maria Santos, Helena Canhão, João Fonseca BMC Medicine 2013, 11:98 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Anti-ribosomal P antibodies (anti-Rib-P) can identify patients with systemic lupus erythematosus (SLE) with high specificity and positive predictive value, indicating that these antibodies could be used in the clinic to improve accuracy of SLE diagnosis.
		Research article Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies Sreeram V Ramagopalan, Raph Goldacre, Andrew Skingsley, Chris Conlon, Michael J Goldacre BMC Medicine 2013, 11:97 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An analysis of hospital admissions and death certificates across England reveals the risk of tuberculosis (TB) is significantly increased in patients with immune-mediated diseases, highlighting the need for TB screening in these patients.
		Review Phosphodiesterase 4-targeted treatments for autoimmune diseases Neal Kumar, Ari M Goldminz, Noori Kim, Alice B Gottlieb BMC Medicine 2013, 11:96 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Phosphodiesterase (PDE) 4-targeted therapies are a promising option to treat a range of autoimmune diseases; Alice Gottlieb and colleagues review the development of PDE4 inhibitors for chronic conditions and discuss recent clinical trial data.
		Review Renal involvement in autoimmune connective tissue diseases Andreas Kronbichler, Gert Mayer BMC Medicine 2013, 11:95 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Andreas Kronbichler and Gert Mayer discuss renal impairment in autoimmune connective tissue disorders (CTDs) caused by underlying disease or drug reactions, and explain how physicians should take kidney function into account when treating CTDs.
		Commentary Age-related autoimmunity Zahava Vadasz, Tharwat Haj, Aharon Kessel, Elias Toubi BMC Medicine 2013, 11:94 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Elias Toubi and colleagues explore why autoimmunity is high in the elderly, and suggest that increased T-regulatory cells, which compensate for lower levels of thymic T-cells, may lead to a pro-inflammatory response, thereby increasing autoimmunity.
		Review Novel aspects of Sjögren’s syndrome in 2012 Angela Tincani, Laura Andreoli, Ilaria Cavazzana, Andrea Doria, Marta Favero, Maria-Giulia Fenini, Franco Franceschini, Andrea Lojacono, Giuseppe Nascimbeni, Amerigo Santoro, Francesco Semeraro, Paola Toniati, Yehuda Shoenfeld BMC Medicine 2013, 11:93 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Angela Tincani and colleagues review the latest developments in Sjogren's Syndrome research and therapies, and highlight a possible link between Vitamin D levels and development of the disease.
		Research article Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice Aviva Katzav, Nikolaos C Grigoriadis, Tania Ebert, Olga Touloumi, Miri Blank, Chaim G Pick, Yehuda Shoenfeld, Joab Chapman BMC Medicine 2013, 11:92 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Transgenic mice induced to develop antiphospholipid syndrome exhibit behavioral and cognitive dysfunction in correlation to the mutation allele load, indicating that the elevated circulating antibodies lead to neurodegeneration.
		Commentary Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy Takahisa Gono, Yasushi Kawaguchi, Hisashi Yamanaka BMC Medicine 2013, 11:91 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Takahisa Gono and colleagues comment on a study in mice in which 16/6 idiotype (Id) antibody impairs memory, and argue antibody cross-reactivity could explain the diverse clinical features in SLE with the autoantibody targets as potential therapies.
		Research article 16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus Shaye Kivity, Aviva Katzav, Maria Arango, Moran Landau-Rabi, Yaron Zafrir, Nancy Agmon-Levin, Miri Blank, Juan-Manuel Anaya, Edna Mozes, Joab Chapman, Yehuda Shoenfeld BMC Medicine 2013, 11:90 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Injection of 16/6 idiotype antibodies in brains of mice induces lupus symptoms, including cognitive impairment and brain inflammation, suggesting involvement of human anti-DNA antibody in cognitive decline and neuropsychiatric symptoms in lupus patients.
		Research article The thrombophilic network of autoantibodies in celiac disease Aaron Lerner, Nancy Agmon-Levin, Yinon Shapira, Boris Gilburd, Sandra Reuter, Idit Lavi, Yehuda Shoenfeld BMC Medicine 2013, 11:89 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Autoantibodies against thrombogenic factors are present at higher levels in children with celiac disease compared with healthy controls, suggesting these antibodies could be a therapeutic target for thrombophilia in celiac patients.
		Review Biologic therapy for autoimmune diseases: an update Ziv Rosman, Yehuda Shoenfeld, Gisele Zandman-Goddard BMC Medicine 2013, 11:88 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gisele Zandman-Goddard and colleagues review the advantages and drawbacks of biologic therapies for autoimmune disease, and discuss the importance of having a range of drugs available to treat patients with severe or resistant disease.
		Editorial Novel pebbles in the mosaic of autoimmunity Carlo Perricone, Nancy Agmon-Levin, Yehuda Shoenfeld BMC Medicine 2013, 11:101 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Yehuda Shoenfeld and colleagues launch our new article collection, Autoimmunity, with an editorial discussing the evolution of autoimmunity research and emerging concepts in the pathology of autoimmune diseases.
		Review Requirements for innate immune pathways in environmentally induced autoimmunity Kenneth Pollard, Dwight H Kono BMC Medicine 2013, 11:100 (4 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Kenneth Pollard and Dwight Kono review the immune pathways involved in idiopathic and environmentally induced autoimmunity, and highlight that further investigation is needed to understand the mechanistic pathways underlying this elusive condition.
		Research article Body mass index and incident coronary heart disease in women: a population-based prospective study Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F. Lucy Wright, Jane Green, Gillian Reeves, Valerie Beral, Million Women Study Collaborators BMC Medicine 2013, 11:87 (2 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Coronary heart disease increases with BMI in over 1 million women and this risk is not confounded by age, smoking, physical activity, alcohol consumption and status, suggesting population changes in BMI will reduce the burden of disease.
		Research article Calcium-deficiency assessment and biomarker identification by an integrated urinary metabonomics analysis Maoqing Wang, Xue Yang, Fan Wang, Ran Li, Hua Ning, Lixin Na, Yifan Huang, Yue Song, Liyan Liu, Hongzhi Pan, Qiuju Zhang, Lijun Fan, Ying Li, Changhao Sun BMC Medicine 2013, 11:86 (28 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A panel of protein biomarkers discriminates between calcium-deficient and non-deficient rats and two of these biomarkers, pseudouridine and citrate, correlate with calcium intake in humans, making them useful to screen for calcium deficiency.
		Review Novel approaches to minimize ventilator-induced lung injury Eddy Fan, Jesus Villar, Arthur S Slutsky BMC Medicine 2013, 11:85 (28 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Arthur Slutsky and colleagues review novel approaches to counteract ventilator-induced lung injury in patients with acute respiratory distress syndrome, discussing studies that minimize biotrauma and the underlying pathophysiology.