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Research article   Open Access

Neuromuscular training with injury prevention counselling to decrease the risk of acute musculoskeletal injury in young men during military service: a population-based, randomised study

Jari Parkkari, Henri Taanila, Jaana Suni, Ville M Mattila, Olli Ohrankämmen, Petteri Vuorinen, Pekka Kannus, Harri Pihlajamäki BMC Medicine 2011, 9:35 (11 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Neuromuscular training and injury prevention counseling is effective in decreasing the risk of acute musculoskeletal injury in young men in the military, and may be applicable to the general population as a means of avoiding injury when exercising.

Debate   Open Access

Would the field of cognitive neuroscience be advanced by sharing functional MRI data?

Kristina M Visscher, Daniel H Weissman BMC Medicine 2011, 9:34 (8 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Visscher and Weissman argue that greater sharing and synthesis of raw functional MRI data will advance cognitive neuroscience by allowing researchers to compare and validate findings, improving our understanding of brain-behaviour relationships at a far greater rate.

Minireview   Open Access Highly Accessed

Understanding the benefit of metformin use in cancer treatment

Ryan JO Dowling, Pamela J Goodwin, Vuk Stambolic BMC Medicine 2011, 9:33 (6 April 2011)

Abstract | Full text | PDF | PubMed | 1 comment |  Editor’s summary

Metformin has long been known to combat diabetes, but its mechanisms of action are now known to also provide potent anti-tumor action, reviewed here by Stambolic and colleagues.

Minireview   Open Access Highly Accessed

Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Niels Høiby BMC Medicine 2011, 9:32 (4 April 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Hoiby reviews recent advances in treatment of chronic Pseudomonas aeruginosa lung infection due to biofilm formation in cystic fibrosis patients, with a focus on inhalation therapy targeted towards prophylaxis and chronic suppressive therapy.

Commentary   Open Access

How can we improve the interpretation of systematic reviews?

Andrea C Tricco, Sharon E Straus, David Moher BMC Medicine 2011, 9:31 (30 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Moher and colleagues comment on recent research published in BMC Medicine on the importance of the correct interpretation of systematic reviews, emphasizing key methodological issues regarding their design and reporting.

Research article   Open Access Highly Accessed

Interpreting systematic reviews: are we ready to make our own conclusions? A cross-sectional study

Nai Lai, Cheong Teng, Ming Lee BMC Medicine 2011, 9:30 (30 March 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Clinicians often rely on systematic reviews as quick sources of evidence based information but may not be able to derive appropriate conclusions from them, often being swayed by their prior beliefs and the direction of the study effects.

Research article   Open Access

Interprofessional simulated learning: short-term associations between simulation and interprofessional collaboration

Chris Kenaszchuk, Kathleen MacMillan, Mary van Soeren, Scott Reeves BMC Medicine 2011, 9:29 (28 March 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Interprofessional simulation education in health professions, whereby participants can explore collaborative ways of improving communicative aspects of clinical care, provide short term improvements in attitudes to teamwork, but this also depends on interpersonal characteristics.

Research article   Open Access

Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer

Callinice D Capo-chichi, Kathy Q Cai, Fiona Simpkins, Parvin Ganjei-Azar, Andrew K Godwin, Xiang-Xi Xu BMC Medicine 2011, 9:28 (26 March 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Defects in nuclear morphology and ploidy, two of the hallmarks of ovarian cancer, may be caused by aberrant nuclear envelope protein lamin A/C expression, which may also cause similar defects in other cancer types.

Question and Answer   Open Access

Q&A: Primary generalized glucocorticoid resistance

George Chrousos BMC Medicine 2011, 9:27 (23 March 2011)

Full text | PDF | PubMed |  Editor’s summary

Prof. George Chrousos, a pioneer in understanding and treating the rare genetic condition, Primary Generalized Glucocorticoid Resistance, responds to calls to rename the condition 'Chrousos syndrome' in recognition of his groundbreaking work in the field.

Research article   Open Access

Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivity

Kamaldeep S Bhui, Sokratis Dinos, Deborah Ashby, James Nazroo, Simon Wessely, Peter D White BMC Medicine 2011, 9:26 (21 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Chronic fatigue syndrome is more prevalent in the ethnic population of the UK compared to their white counterparts, perhaps due to the associated higher incidence of anxiety, depression and social strain.

Review   Open Access

Regulation of vascular tone by adipocytes

Nele Maenhaut, Johan Van de Voorde BMC Medicine 2011, 9:25 (16 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Maenhaut and Van de Voorde review the biology of adipokines, whose secretion in adipose tissue is dysregulated in the obese leading to compromised vascular tone that in turn may underlie increased risks of obesity co-morbities such as hypertension.

Debate   Open Access Highly Accessed

'Gut health': a new objective in medicine?

Stephan C Bischoff BMC Medicine 2011, 9:24 (14 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Understanding how to assess, improve and maintain gastrointestinal (GI) functions and the GI barrier are key to overall 'gut health'; Stephan Bischoff describes the potential impact of using measures of gut health for preventive medicine.

Research article   Open Access Highly Accessed

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.

Research article   Open Access Highly Accessed

Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report

Paolo Zamboni, Erica Menegatti, Bianca Weinstock-Guttman, Michael G Dwyer, Claudiu V Schirda, Anna M Malagoni, David Hojnacki, Cheryl Kennedy, Ellen Carl, Niels Bergsland, Christopher Magnano, Ilaria Bartolomei, Fabrizio Salvi, Robert Zivadinov BMC Medicine 2011, 9:22 (7 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments |  Editor’s summary

Multiple Sclerosis (MS) patients have impairments in their cerebral blood flow and now pilot results indicate this could be related to a condition called chronic cerebrospinal venous insufficiency helping researchers to understand axon degeneration in this condition

Research article   Open Access

Analyses of cerebral microdialysis in patients with traumatic brain injury: relations to intracranial pressure, cerebral perfusion pressure and catheter placement

David W Nelson, Björn Thornquist, Robert M MacCallum, Harriet Nyström, Anders Holst, Anders Rudehill, Michael Wanecek, Bo-Michael Bellander, Eddie Weitzberg BMC Medicine 2011, 9:21 (2 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In conflict with expectations of microdialysis as a dynamic monitor of ischemia, used for interpretation and decision-making in patients with traumatic brain injury, real-time microdialysis data do not correlate well with established markers of cerebral blood flow.

Debate   Open Access

Significance testing as perverse probabilistic reasoning

M Brandon Westover, Kenneth D Westover, Matt T Bianchi BMC Medicine 2011, 9:20 (28 February 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Basic concepts to prevent misunderstanding of underlying probabilistic logic of significance tests are explained by Westover and colleagues, highlighting the surprising finding that over 90% of physicians questioned misunderstood these tests and therefore their results.

Research article   Open Access

MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility

Cherry Chang, Hui-Wen Chang, Chih-Mei Chen, Chia-Ying Lin, Chih-Ping Chen, Chih-Ho Lai, Wei-Yong Lin, Hsing-Ping Liu, Jim Sheu, Fuu-Jen Tsai BMC Medicine 2011, 9:19 (24 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Mucin 4 (MUC4) is involved in mucous production, and polymorphisms in the MUC4 gene are associated with the development endometriosis, a chronic gynecological condition characterized by pelvic pain and heavy menstruation, as well as endometriosis-related infertility.

Research article   Open Access Highly Accessed

EEG complexity as a biomarker for autism spectrum disorder risk

William Bosl, Adrienne Tierney, Helen Tager-Flusberg, Charles Nelson BMC Medicine 2011, 9:18 (22 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Subtle brain function signatures computed from resting state EEG signals may be a novel biomarker for early detection of abnormalities in infants at high risk of Autism Spectrum Disorder.

Commentary   Open Access Highly Accessed

Effectively incorporating selected multimedia content into medical publications

Alexander Ziegler, Daniel Mietchen, Cornelius Faber, Wolfram von Hausen, Christoph Schöbel, Markus Sellerer, Andreas Ziegler BMC Medicine 2011, 9:17 (17 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Ziegler and colleagues describe the benefits to electronic medical publications of the seamless incorporation of audio, visual and 3D image files into the article PDF, removing the need for supplemental files.

Research article   Open Access

Comparison of postmenopausal endogenous sex hormones among Japanese, Japanese Brazilians, and non-Japanese Brazilians

Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Gerson Hamada, Ines Nishimoto, Maria Maciel, Juvenal Motola, Fábio Laginha, Roberto Anzai, Shoichiro Tsugane BMC Medicine 2011, 9:16 (16 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Higher levels of estrogens and androgens in Japanese Brazilians than in Japanese women living in Japan may help explain the increase in incidence and mortality of breast cancer among Japanese Brazilians.

Minireview   Open Access Highly Accessed

Pregnancy-related pelvic girdle pain: an update

Nikolaos K Kanakaris, Craig S Roberts, Peter V Giannoudis BMC Medicine 2011, 9:15 (15 February 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Giannoudis and colleagues review the scientific and clinical implications of PPGP, a syndrome that requires the multidisciplinary interaction of a wide number of health related specialties, and propose diagnosis algorithms and treatment options.

Question and Answer   Open Access Highly Accessed

Q&A: The 'three Ps' of cancer survivorship care

Patricia A Ganz BMC Medicine 2011, 9:14 (10 February 2011)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Patricia Ganz describes the importance of adequate post-treatment care for cancer survivors and introduces her recommended 'Three Ps' to improve survivorship care.

Commentary   Open Access

Another tool in the genome-wide association study arsenal: population-based detection of somatic gene conversion

Matthew A Deardorff, Jesus Sainz, Struan FA Grant BMC Medicine 2011, 9:13 (3 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Struan Grant and colleagues discuss recent research in BMC Medicine examining the importance of somatic gene conversions and deletions in genome-wide association studies to more fully investigate the genetic component of disease mechanisms.

Research article   Open Access

Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes

Kenneth Ross BMC Medicine 2011, 9:12 (3 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Gene conversion could be a significant causative factor in numerous diseases, including autoimmune and psychiatric disorders as well as coronary artery disease, with identification of converted genes allowing further dissection of disease mechanisms.

Minireview   Open Access

Advances in understanding ischemic acute kidney injury

Raj Munshi, Christine Hsu, Jonathan Himmelfarb BMC Medicine 2011, 9:11 (2 February 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Munshi and colleagues review the pathophysiology and therapeutic developments for ischemic acute kidney injury, the leading cause of chronic kidney disease that currently lacks effective treatment.

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