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Neuromuscular training with injury prevention counselling to decrease the risk of acute musculoskeletal injury in young men during military service: a population-based, randomised study
Jari Parkkari, Henri Taanila, Jaana Suni, Ville M Mattila, Olli Ohrankämmen, Petteri Vuorinen, Pekka Kannus, Harri Pihlajamäki BMC Medicine 2011, 9:35 (11 April 2011)
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Editor’s summary
Neuromuscular training and injury prevention counseling is effective in decreasing the risk of acute musculoskeletal injury in young men in the military, and may be applicable to the general population as a means of avoiding injury when exercising.
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Would the field of cognitive neuroscience be advanced by sharing functional MRI data?
Kristina M Visscher, Daniel H Weissman BMC Medicine 2011, 9:34 (8 April 2011)
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Editor’s summary
Visscher and Weissman argue that greater sharing and synthesis of raw functional MRI data will advance cognitive neuroscience by allowing researchers to compare and validate findings, improving our understanding of brain-behaviour relationships at a far greater rate.
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Understanding the benefit of metformin use in cancer treatment
Ryan JO Dowling, Pamela J Goodwin, Vuk Stambolic BMC Medicine 2011, 9:33 (6 April 2011)
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Metformin has long been known to combat diabetes, but its mechanisms of action are now known to also provide potent anti-tumor action, reviewed here by Stambolic and colleagues.
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Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
Niels Høiby BMC Medicine 2011, 9:32 (4 April 2011)
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Hoiby reviews recent advances in treatment of chronic Pseudomonas aeruginosa lung infection due to biofilm formation in cystic fibrosis patients, with a focus on inhalation therapy targeted towards prophylaxis and chronic suppressive therapy.
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How can we improve the interpretation of systematic reviews?
Andrea C Tricco, Sharon E Straus, David Moher BMC Medicine 2011, 9:31 (30 March 2011)
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Editor’s summary
Moher and colleagues comment on recent research published in BMC Medicine on the importance of the correct interpretation of systematic reviews, emphasizing key methodological issues regarding their design and reporting.
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Interpreting systematic reviews: are we ready to make our own conclusions? A cross-sectional study
Nai Lai, Cheong Teng, Ming Lee BMC Medicine 2011, 9:30 (30 March 2011)
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Editor’s summary
Clinicians often rely on systematic reviews as quick sources of evidence based information but may not be able to derive appropriate conclusions from them, often being swayed by their prior beliefs and the direction of the study effects.
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Interprofessional simulated learning: short-term associations between simulation and interprofessional collaboration
Chris Kenaszchuk, Kathleen MacMillan, Mary van Soeren, Scott Reeves BMC Medicine 2011, 9:29 (28 March 2011)
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Editor’s summary
Interprofessional simulation education in health professions, whereby participants can explore collaborative ways of improving communicative aspects of clinical care, provide short term improvements in attitudes to teamwork, but this also depends on interpersonal characteristics.
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Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer
Callinice D Capo-chichi, Kathy Q Cai, Fiona Simpkins, Parvin Ganjei-Azar, Andrew K Godwin, Xiang-Xi Xu BMC Medicine 2011, 9:28 (26 March 2011)
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Editor’s summary
Defects in nuclear morphology and ploidy, two of the hallmarks of ovarian cancer, may be caused by aberrant nuclear envelope protein lamin A/C expression, which may also cause similar defects in other cancer types.
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Q&A: Primary generalized glucocorticoid resistance
George Chrousos BMC Medicine 2011, 9:27 (23 March 2011)
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Editor’s summary
Prof. George Chrousos, a pioneer in understanding and treating the rare genetic condition, Primary Generalized Glucocorticoid Resistance, responds to calls to rename the condition 'Chrousos syndrome' in recognition of his groundbreaking work in the field.
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Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivity
Kamaldeep S Bhui, Sokratis Dinos, Deborah Ashby, James Nazroo, Simon Wessely, Peter D White BMC Medicine 2011, 9:26 (21 March 2011)
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Editor’s summary
Chronic fatigue syndrome is more prevalent in the ethnic population of the UK compared to their white counterparts, perhaps due to the associated higher incidence of anxiety, depression and social strain.
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Regulation of vascular tone by adipocytes
Nele Maenhaut, Johan Van de Voorde BMC Medicine 2011, 9:25 (16 March 2011)
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Editor’s summary
Maenhaut and Van de Voorde review the biology of adipokines, whose secretion in adipose tissue is dysregulated in the obese leading to compromised vascular tone that in turn may underlie increased risks of obesity co-morbities such as hypertension.
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'Gut health': a new objective in medicine?
Stephan C Bischoff BMC Medicine 2011, 9:24 (14 March 2011)
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Editor’s summary
Understanding how to assess, improve and maintain gastrointestinal (GI) functions and the GI barrier are key to overall 'gut health'; Stephan Bischoff describes the potential impact of using measures of gut health for preventive medicine.
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Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity
Anna Sapone, Karen M Lammers, Vincenzo Casolaro, Marcella Cammarota, Maria Giuliano, Mario De Rosa, Rosita Stefanile, Giuseppe Mazzarella, Carlo Tolone, Maria Russo, Pasquale Esposito, Franca Ferraraccio, Maria Cartenì, Gabriele Riegler, Laura de Magistris, Alessio Fasano BMC Medicine 2011, 9:23 (9 March 2011)
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Editor’s summary
Celiac disease and gluten sensitivity sufferers have similar pathologies triggered by gluten ingestion, but have different mucosal immune profiles and gut permeabilities, which may explain the less severe pathology of gluten sensitivity as compared to celiac disease.
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Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report
Paolo Zamboni, Erica Menegatti, Bianca Weinstock-Guttman, Michael G Dwyer, Claudiu V Schirda, Anna M Malagoni, David Hojnacki, Cheryl Kennedy, Ellen Carl, Niels Bergsland, Christopher Magnano, Ilaria Bartolomei, Fabrizio Salvi, Robert Zivadinov BMC Medicine 2011, 9:22 (7 March 2011)
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Editor’s summary
Multiple Sclerosis (MS) patients have impairments in their cerebral blood flow and now pilot results indicate this could be related to a condition called chronic cerebrospinal venous insufficiency helping researchers to understand axon degeneration in this condition
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Analyses of cerebral microdialysis in patients with traumatic brain injury: relations to intracranial pressure, cerebral perfusion pressure and catheter placement
David W Nelson, Björn Thornquist, Robert M MacCallum, Harriet Nyström, Anders Holst, Anders Rudehill, Michael Wanecek, Bo-Michael Bellander, Eddie Weitzberg BMC Medicine 2011, 9:21 (2 March 2011)
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Editor’s summary
In conflict with expectations of microdialysis as a dynamic monitor of ischemia, used for interpretation and decision-making in patients with traumatic brain injury, real-time microdialysis data do not correlate well with established markers of cerebral blood flow.
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Significance testing as perverse probabilistic reasoning
M Brandon Westover, Kenneth D Westover, Matt T Bianchi BMC Medicine 2011, 9:20 (28 February 2011)
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Editor’s summary
Basic concepts to prevent misunderstanding of underlying probabilistic logic of significance tests are explained by Westover and colleagues, highlighting the surprising finding that over 90% of physicians questioned misunderstood these tests and therefore their results.
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MUC4 gene polymorphisms associate with endometriosis development and endometriosis-related infertility
Cherry Chang, Hui-Wen Chang, Chih-Mei Chen, Chia-Ying Lin, Chih-Ping Chen, Chih-Ho Lai, Wei-Yong Lin, Hsing-Ping Liu, Jim Sheu, Fuu-Jen Tsai BMC Medicine 2011, 9:19 (24 February 2011)
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Editor’s summary
Mucin 4 (MUC4) is involved in mucous production, and polymorphisms in the MUC4 gene are associated with the development endometriosis, a chronic gynecological condition characterized by pelvic pain and heavy menstruation, as well as endometriosis-related infertility.
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EEG complexity as a biomarker for autism spectrum disorder risk
William Bosl, Adrienne Tierney, Helen Tager-Flusberg, Charles Nelson BMC Medicine 2011, 9:18 (22 February 2011)
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Editor’s summary
Subtle brain function signatures computed from resting state EEG signals may be a novel biomarker for early detection of abnormalities in infants at high risk of Autism Spectrum Disorder.
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Effectively incorporating selected multimedia content into medical publications
Alexander Ziegler, Daniel Mietchen, Cornelius Faber, Wolfram von Hausen, Christoph Schöbel, Markus Sellerer, Andreas Ziegler BMC Medicine 2011, 9:17 (17 February 2011)
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Editor’s summary
Ziegler and colleagues describe the benefits to electronic medical publications of the seamless incorporation of audio, visual and 3D image files into the article PDF, removing the need for supplemental files.
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Comparison of postmenopausal endogenous sex hormones among Japanese, Japanese Brazilians, and non-Japanese Brazilians
Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Gerson Hamada, Ines Nishimoto, Maria Maciel, Juvenal Motola, Fábio Laginha, Roberto Anzai, Shoichiro Tsugane BMC Medicine 2011, 9:16 (16 February 2011)
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Editor’s summary
Higher levels of estrogens and androgens in Japanese Brazilians than in Japanese women living in Japan may help explain the increase in incidence and mortality of breast cancer among Japanese Brazilians.
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Pregnancy-related pelvic girdle pain: an update
Nikolaos K Kanakaris, Craig S Roberts, Peter V Giannoudis BMC Medicine 2011, 9:15 (15 February 2011)
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Giannoudis and colleagues review the scientific and clinical implications of PPGP, a syndrome that requires the multidisciplinary interaction of a wide number of health related specialties, and propose diagnosis algorithms and treatment options.
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Q&A: The 'three Ps' of cancer survivorship care
Patricia A Ganz BMC Medicine 2011, 9:14 (10 February 2011)
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Editor’s summary
Patricia Ganz describes the importance of adequate post-treatment care for cancer survivors and introduces her recommended 'Three Ps' to improve survivorship care.
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Another tool in the genome-wide association study arsenal: population-based detection of somatic gene conversion
Matthew A Deardorff, Jesus Sainz, Struan FA Grant BMC Medicine 2011, 9:13 (3 February 2011)
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Editor’s summary
Struan Grant and colleagues discuss recent research in BMC Medicine examining the importance of somatic gene conversions and deletions in genome-wide association studies to more fully investigate the genetic component of disease mechanisms.
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Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes
Kenneth Ross BMC Medicine 2011, 9:12 (3 February 2011)
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Editor’s summary
Gene conversion could be a significant causative factor in numerous diseases, including autoimmune and psychiatric disorders as well as coronary artery disease, with identification of converted genes allowing further dissection of disease mechanisms.
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Advances in understanding ischemic acute kidney injury
Raj Munshi, Christine Hsu, Jonathan Himmelfarb BMC Medicine 2011, 9:11 (2 February 2011)
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Editor’s summary
Munshi and colleagues review the pathophysiology and therapeutic developments for ischemic acute kidney injury, the leading cause of chronic kidney disease that currently lacks effective treatment.
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