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Volume 9 (2011) - June 2011

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Research article   Open Access

Tinnitus in elderly patients and prognosis of mild-to-moderate congestive heart failure: a cross-sectional study with a long-term extension of the clinical follow-up

Claudio Borghi, Eugenio R Cosentino, Elisa R Rinaldi, Cristina Brandolini, Maria C Rimondi, Maddalena Veronesi, Arrigo FG Cicero, Ada Dormi, Antonio Pirodda BMC Medicine 2011, 9:80 (29 June 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Tinnitus is a complex ear disorder affecting microcirculation, and preliminary data indicates that it may have prognostic value for identifying poorly controlled congestive heart failure (CHF) in the elderly population, alongside other determinants.

Commentary   Open Access

Network meta-analysis-highly attractive but more methodological research is needed

Tianjing Li, Milo A Puhan, Swaroop S Vedula, Sonal Singh, Kay Dickersin, The Ad Hoc Network Meta-analysis Methods Meeting Working Group BMC Medicine 2011, 9:79 (27 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Li et al comment on a meeting regarding network meta-analysis, a type of meta-analysis used in systematic reviews in which multiple treatments are compared, and discuss the methodological challenges and research opportunities in this field.

Research article   Open Access

Accounting for the mortality benefit of drug-eluting stents in percutaneous coronary intervention: a comparison of methods in a retrospective cohort study

Robert W Yeh, Malini Chandra, Charles E McCulloch, Alan S Go BMC Medicine 2011, 9:78 (24 June 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The benefit of drug-eluting stents for patients with coronary artery disease compared to bare metal ones is the result of bias in observational studies as randomized controlled trials show no difference in mortality outcome regardless of the type of stent used.

Research article   Open Access Highly Accessed

Problematic internet usage in US college students: a pilot study

Dimitri A Christakis, Megan M Moreno, Lauren Jelenchick, Mon T Myaing, Chuan Zhou BMC Medicine 2011, 9:77 (22 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Problematic internet usage is prevalent among US college students, suggesting that colleges should consider preventative measures including awareness campaigns and, as internet usage starts at a young age, pediatricians should also assess this as part of preventative practice.

Research article   Open Access

Diabetes mellitus type 2 and other chronic non-communicable diseases in the central region, Saudi Arabia (riyadh cohort 2): a decade of an epidemic

Nasser M Al-Daghri, Omar S Al-Attas, Majed S Alokail, Khalid M Alkharfy, Mansour Yousef, Shaun Sabico, George P Chrousos BMC Medicine 2011, 9:76 (20 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

A decade-long epidemiological follow-up study on the prevalence of major chronic, non-communicable diseases in the Kingdom of Saudi Arabia finds an alarming rise in the prevalence of type 2 diabetes, hypertension and coronary artery disease.

Research article   Open Access

Best practice for motor imagery: a systematic literature review on motor imagery training elements in five different disciplines

Corina Schuster, Roger Hilfiker, Oliver Amft, Anne Scheidhauer, Brian Andrews, Jenny Butler, Udo Kischka, Thierry Ettlin BMC Medicine 2011, 9:75 (17 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Mental practice of a physical task can improve skill in areas such as education, medicine, music and sports, and characteristics of successful motor imagery training sessions across disciplines are similar despite differences in the physical tasks themselves.

Research article   Open Access

Efficacy of aerobic exercise and a prudent diet for improving selected lipids and lipoproteins in adults: a meta-analysis of randomized controlled trials

George A Kelley, Kristi S Kelley, Susan Roberts, William Haskell BMC Medicine 2011, 9:74 (15 June 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Aerobic exercise in combination with a prudent diet, low in saturated fats, improves certain lipid and lipoprotein concentrations including total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C) but has no effect on high-density lipoprotein cholesterol (HDL-C).

Research article   Open Access

High prevalence of potential biases threatens the interpretation of trials in patients with chronic disease

Daniela Vollenweider, Cynthia M Boyd, Milo A Puhan BMC Medicine 2011, 9:73 (13 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

There is a high prevalence of potential biases within the design and analysis of clinical trials, which may threaten trial interpretation and therefore the safety and efficacy of clinical decision making.

Minireview   Open Access Highly Accessed

Advances in understanding and treating ADHD

Kevin M Antshel, Teresa M Hargrave, Mihai Simonescu, Prashant Kaul, Kaitlin Hendricks, Stephen V Faraone BMC Medicine 2011, 9:72 (10 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Antshel and colleagues review the advances over the past decade in the understanding and treatment of Attention Deficit Hyperactivity Disorder (ADHD), which comprise both tailored stimulant formulations and cognitive behavioral interventions.

Research article   Open Access

FTO gene polymorphisms and obesity risk: a meta-analysis

Sihua Peng, Yimin Zhu, Fangying Xu, Xiaobin Ren, Xiaobo Li, Maode Lai BMC Medicine 2011, 9:71 (8 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Polymorphisms of the fat mass and obesity associated gene (FTO), which is already known to increase the risk for obesity in Europeans and Caucasians, may also be a risk factor in other ethnicities.

Review   Open Access Highly Accessed

The role of lifestyle changes in the management of chronic liver disease

Valerio Nobili, Christine Carter-Kent, Ariel E Feldstein BMC Medicine 2011, 9:70 (6 June 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Ariel Feldstein and colleagues review chronic liver conditions that can be directly affected by obesity, also discussing the lifestyle interventions that lead to better physical outcome for these conditions.

Research article   Open Access Highly Accessed

α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation

Masa-Aki Shibata, Munekazu Iinuma, Junji Morimoto, Hitomi Kurose, Kanako Akamatsu, Yasushi Okuno, Yukihiro Akao, Yoshinori Otsuki BMC Medicine 2011, 9:69 (3 June 2011)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Alpha-mangostin, an extract from the mangosteen fruit, demonstrates antitumor growth and antimetastatic activities by decreasing Akt phosphorylation levels in a mouse model of breast cancer and therefore may have clinical applications.

Research article   Open Access

Differential properties of human ACL and MCL stem cells may be responsible for their differential healing capacity

Jianying Zhang, Tiffany Pan, Hee-Jeong Im, Freddie H Fu, James HC Wang BMC Medicine 2011, 9:68 (2 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Two knee ligaments often injured in athletes are known to have different healing capabilities and these are now shown to possess different stem cell populations with varying regeneration capacity – shedding light on the potential mechanism for the disparity.

Research article   Open Access

Predicting streptococcal pharyngitis in adults in primary care: a systematic review of the diagnostic accuracy of symptoms and signs and validation of the Centor score

Jolien Aalbers, Kirsty K O'Brien, Wai-Sun Chan, Gavin A Falk, Conor Teljeur, Borislav D Dimitrov, Tom Fahey BMC Medicine 2011, 9:67 (1 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Centor Score, which predicts streptococcal pharyngitis in adults with sore throat, is found to be well-calibrated for estimating probability of infection, and may enhance appropriate antibiotic prescriptions.


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