Articles
Volume 9 (2011) - January 2011
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Research article
Christos A Papadimitriou, Pavlos Papakostas, Maria Karina, Lia Malettou, Meletios A Dimopoulos, George Pentheroudakis, Epaminontas Samantas, Aristotelis Bamias, Dimosthenis Miliaras, George Basdanis, Nikolaos Xiros, George Klouvas, Dimitrios Bafaloukos, Georgia Kafiri, Irene Papaspirou, Dimitrios Pectasides, Charisios Karanikiotis, Theofanis Economopoulos, Ioannis Efstratiou, Ippokratis Korantzis, Nikolaos Pisanidis, Thomas Makatsoris, Fotini Matsiakou, Gerasimos Aravantinos, Haralabos P Kalofonos, George Fountzilas BMC Medicine 2011, 9:10 (31 January 2011) A randomised controlled trial has found that addition of irinotecan into the standard chemotherapy regime does not increase rates of disease-free or overall survival in stage II or III colon cancer sufferers, but does increase toxicity.
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Research article
Elias Zintzaras, Chrysoula Doxani, Theocharis Koufakis, Alkibiadis Kastanis, Paraskevi Rodopoulou, Theofilos Karachalios BMC Medicine 2011, 9:9 (26 January 2011) A new web-based system of ongoing meta-analyses provides new evidence to implicate focal adhesion genes in osteoporosis, by synthesizing data from underpowered genetic association studies.
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Research article
Carel Bron, Arthur de Gast, Jan Dommerholt, Boudewijn Stegenga, Michel Wensing, Rob AB Oostendorp BMC Medicine 2011, 9:8 (24 January 2011) Treatment of ‘trigger points’ in shoulder muscles significantly reduces symptoms and improves shoulder function for patients with chronic non-traumatic shoulder pain, as part of a physical therapy treatment program.
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Research article
Kokuvi Atsou, Christos Chouaid, Gilles Hejblum BMC Medicine 2011, 9:7 (18 January 2011) Epidemiological characteristics of chronic obstructive pulmonary disease (COPD) as well as the methods used to estimate them vary widely across European countries, so standardizing data collection should be enhanced for improved decision-making on preventive measures and patient management
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Research article
Feng Zhou, Gerald F Kominski, Han-Zhu Qian, Jiansheng Wang, Song Duan, Zhiwei Guo, Xinping Zhao BMC Medicine 2011, 9:6 (17 January 2011) Initiating anti-retroviral treatment earlier in HIV-infected individuals in China’s healthcare system would reduce the associated costs of adverse drug reactions and opportunistic infections, although it would likely increase treatment costs over the long-term.
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Research article
Patrick Gérardin, Adrian Fianu, Denis Malvy, Corinne Mussard, Karim Boussaïd, Olivier Rollot, Alain Michault, Bernard-Alex Gaüzere, Gérard Bréart, François Favier BMC Medicine 2011, 9:5 (14 January 2011) Chikungunya virus, a mosquito-borne pathogen that caused a recent outbreak in La Réunion, also has long-term health consequences including prolonged or late-onset rheumatologic and neurological side-effects, further burdening an already vulnerable community.
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Research article
Der-Yuan Chen, Hui-Min Chih, Joung-Liang Lan, Hsin-Yueh Chang, Wei-Wen Chen, En-Pei Chiang BMC Medicine 2011, 9:4 (13 January 2011) Low doses of methotrexate, a commonly prescribed drug for rheumatoid arthritis, affects cholesterol metabolism at the mRNA level by increasing the expression of cholesterol efflux genes.
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Research article
Horst Neubauer, Andreas FC Kaiser, Heinz G Endres, Jan C Krüger, Andreas Engelhardt, Sebastian Lask, Fenena Pepinghege, Andreas Kusber, Andreas Mügge BMC Medicine 2011, 9:3 (12 January 2011) A clinical trial suggests that clopidogrel and aspirin treatment for anti-platelet therapy after coronary stenting is more effective when tailored to the patient, including testing for predictive risk factors such as dual resistance.
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Research article
P Wei, LC Milbauer, J Enenstein, J Nguyen, W Pan, RP Hebbel BMC Medicine 2011, 9:2 (11 January 2011) Differences in blood vessel gene expression patterns between African-Americans and Caucasian-Americans, potentially derived from ancestral continent-of-origin genetic influences, may contribute to the disparity in vascular-related disease risks seen in these two groups, including stroke and some cancers.
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Research article
Sreeram V Ramagopalan, Clare J Wotton, Adam E Handel, David Yeates, Michael J Goldacre BMC Medicine 2011, 9:1 (10 January 2011) Venous blood clot formation, a common complication after invasive surgical procedures, may also be a particular risk for hospitalized patients with immune-mediated diseases, such as rheumatoid arthritis and systemic lupus erythematosus.
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