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Volume 6 (2008) - December 2008

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Research article   Open Access

Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Aβ42 reduces their differentiation potential

Markus Uhrig, Peter Brechlin, Olaf Jahn, Yuri Knyazev, Annette Weninger, Laura Busia, Kamran Honarnejad, Markus Otto, Tobias Hartmann BMC Medicine 2008, 6:38 (16 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Increased expression of cellular retinoic acid binding protein 1 (CRABP1) in response to beta-amyloid peptide over-expression induces cell proliferation and reduced differentiation potential in human neuroblastoma cells, suggesting a potential mechanism for neurogenesis in Alzheimer's disease.

Research article   Open Access

A controlled trial of the effectiveness of internet continuing medical education

Linda Casebeer, Sally Engler, Nancy Bennett, Martin Irvine, Destry Sulkes, Marc DesLauriers, Sijian Zhang BMC Medicine 2008, 6:37 (4 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Doctors are more likely to make evidence-based clinical choices after taking part in selected internet continuing medical education (CME) activities, suggesting that such internet-based education may be a credible, high-impact source of CME.