Volume 6 (2008) - April 2008
Paolo P Provenzano, David R Inman, Kevin W Eliceiri, Justin G Knittel, Long Yan, Curtis T Rueden, John G White, Patricia J Keely BMC Medicine 2008, 6:11 (28 April 2008)
Increased stromal collagen density in mouse mammary tissue increases both tumor formation and tumor cell invasive and migratory properties by three fold; furthermore, a metabolic signature for flavin adenine dinucleotide is identified in invading metastatic cells.
Gunilla Kanter-Smoler, Kaisa Fritzell, Anna Rohlin, Yvonne Engwall, Birgitta Hallberg, Annika Bergman, Johan Meuller, Henrik Grönberg, Per Karlsson, Jan Björk, Margareta Nordling BMC Medicine 2008, 6:10 (24 April 2008)
Utilizing a multi-methodological approach to mutation analysis, a 100% detection frequency is achieved in a Swedish classical familial adenomatous polyposis (FAP) cohort, resulting in a number of new APC mutations and the discovery of some unusual mechanisms of APC gene inactivation.