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Volume 2 (2004) - October 2004

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Research article   Open Access Highly Accessed

Acetylcysteine for prevention of contrast-induced nephropathy after intravascular angiography: A systematic review and meta-analysis

Sean M Bagshaw, William A Ghali BMC Medicine 2004, 2:38 (22 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A systematic review shows that the efficacy of acetylcysteine for the prevention of contrast-induced nephropathy on patients undergoing angiography remains unclear and highlights the need for a large, multi-center trial.

Research article   Open Access Highly Accessed

Significance of MDR1 and multiple drug resistance in refractory human epileptic brain

Nicola Marchi, Kerri L Hallene, Kelly M Kight, Luca Cucullo, Gabriel Moddel, William Bingaman, Gabriele Dini, Annamaria Vezzani, Damir Janigro BMC Medicine 2004, 2:37 (9 October 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The overexpression of multiple drug resistance protein (MDR1) in cells from the brains of epileptics who are refractory to drug treatment may result in lower penetrance of drugs into active sites and also be associated with higher neuroglial survival and reduced apoptosis.