Review & comment

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  Smoking & depression:study designs

  Peter de Jonge, Elisabeth Bos

  Peter de Jonge and Elisabeth Bos comment on a study showing smoking is a predictor of depression in heart disease patients, but argue that the use of both nomothetic and idiographic methods will provide more valid data.

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  Processed meat and health risks

  Renata Micha, Georgios Michas, Martin Lajous, Dariush Mozaffarian

  Dariush Mozaffarian and colleagues comment on a study showing that processed meat is linked to increased mortality risk, and emphasize how health guidance should recommend avoiding processed meat rather than focusing on fat content.

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  OCD diagnosis revised in DSM-5

  Dan Stein, Katharine Phillips

  Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account.

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  Personalized medicine in psychiatry

  Uzoezi Ozomaro, Claes Wahlestedt, Charles Nemeroff

  Charles Nemeroff and colleagues review the genetics, epigenetics, biomarkers, treatment response and environmental factors of mood disorders and schizophrenia, and describe the impact of neuroimaging on personalized medicine in psychiatry.

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  Depression: a risk factor for heart disease?

  Kenneth Freedland, Robert Carney

  Kenneth Freedland and Robert Carney argue that depression predicts coronary heart disease (CHD) but better methods are required to ascertain whether depression is a causal risk factor for CHD, which could help determine treatment strategies for CVD prevention.

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  Depression is non-causal in CHD

  Anna Meijer, Marij Zuidersma, Peter de Jonge

  Peter de Jonge and colleagues argue that, although there is a link between coronary heart disease (CHD) and depression, this association is confounded by heterogeneity, such that depression is a non-causal risk factor CHD.