BMC Medicine is the flagship medical journal of the BMC series, publishing original research, commentaries and reviews that are either of significant interest to all areas of medicine and clinical practice, or provide key translational or clinical advances in a specific field.


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    Quantifying benefits and harms

    Milo Puhan, Tsung Yu, Cynthia Boyd, Gerben ter Riet

    Randomized trials are not always the best way to ascertain the benefit of medical interventions; Milo Puhan and colleagues argue that quantitative benefit-herm assessments should be used to guide further research, discussing rofilumast as an example. 

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    Aspirin and multiple sclerosis

    Sheila Tsau, Mitchell Emerson, Sharon Lynch, Steven LeVine

    Steven LeVine and colleagues review the possible risks and benefits of using aspirin to reduce cardiovascular risk for multiple sclerosis (MS) patients, concluding that population-based studies are needed to establish guidance for aspirin use in MS.

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    Down syndrome and cancer 

    Shaista Hafeez, Mausam Singhera, Robert Huddart

    Treating cancer in patients with learning disabilities can be challenging; Robert Huddart and colleagues discuss the management of testicular cancer in those with Down syndrome, concluding that a high cure rate can be achieved with appropriate therapy. 

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    Limiting surgery in breast cancer

    Abigail Caudle, Henry Kuerer

    Abigail Caudle and Henry Kuerer review the management of lymph node metastases in breast cancer, highlighting that axillary lymph node dissection is no longer necessary in all patients, and discussing ways in which surgery could be reduced in the future.

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    REF: measuring research impact

    Saba Hinrichs, Jonathan Grant

    Research Excellence Framework (REF) is a new system for assessing quality of UK research; here Saba Hinrichs and Jonathan Grant describe how information from case studies can be used to explore how research outcomes contribute to various levels of impact and health gains.

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    Big Data and Dementia

    Martin Hofmann-Apitius

    Although Big Data provides exciting avenues for medical research, Martin Hofmann-Apitius highlights that with regard to complex diseases such as dementia, caution is needed to assess how Big Data approaches can reliably inform dementia research.


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BMC Medicine in the news

Tobacco smoking and all-cause mortality in a large Australian cohort study: findings from a mature epidemic with current low smoking prevalence
Emily Banks, Grace Joshy, Marianne F Weber, Bette Liu, Robert Grenfell, Sam Egger, Ellie Paige, Alan D Lopez, Freddy Sitas and Valerie Beral
BMC Medicine 2015, 13:38


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ISSN: 1741-7015