Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes
Maoyin Pang, Shashi Bala, Karen Kodys, Donna Catalano, Gyongyi Szabo
BMC Immunology 2011, 12:55 (30 September 2011)
Acute and prolonged alcohol use has a profound inhibitory effect on Type I Interferon (IFN) induction regardless of intracellular or cell surface-derived danger signals and impairs Type I IFN responses to viral or bacterial pathogen-derived signals.
Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets
Chuanwu Wang, Peter Hillsamer, Chang H Kim
BMC Immunology 2011, 12:53 (13 September 2011)
PD-1 signaling restrains the B-cell helping function and proliferation of a PD-1-expressing, germinal center-localized, T cell subset by preventing excessive antibody response, supporting the role of PD-1 in promoting tolerance in humoral immunity.
Inhibitory effects of the JAK inhibitor CP690,550 on human CD4
+ T lymphocyte cytokine production
Kiyoshi Migita, Taiichiro Miyashita, Yasumori Izumi, Tomohiro Koga, Atsumasa Komori, Yumi Maeda, Yuka Jiuchi, Yoshihiro Aiba, Satoshi Yamasaki, Atsushi Kawakami, Minoru Nakamura, Hiromi Ishibashi
BMC Immunology 2011, 12:51 (31 August 2011)
Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
Kiran Assi, Scott Patterson, Shoukat Dedhar, David Owen, Megan Levings, Baljinder Salh
BMC Immunology 2011, 12:42 (1 August 2011)
Epithelial integrin-linked kinase (ILK) plays a pro-inflammatory role in intestinal inflammation through effects on chemokine expression, the extracellular matrix and immune tolerance, indicating modulation of ILK signaling may have an impact on human inflammatory bowel disease.
Detection of autoreactive CD4 T cells using major histocompatibility complex class II dextramers
Chandirasegaran Massilamany, Bijaya Upadhyaya, Arunakumar Gangaplara, Charles Kuszynski, Jay Reddy
BMC Immunology 2011, 12:40 (18 July 2011)
Major histocompatibility complex (MHC) class II dextramers may permit ex vivo enumeration of CD4 T cells, including self-reactive cells, with specificity and with a detection sensitivity significantly higher than that achieved with conventional tetramers.
Differential MHC class I expression in distinct leukocyte subsets
Justin M Greene, Roger W Wiseman, Simon M Lank, Benjamin N Bimber, Julie A Karl, Benjamin J Burwitz, Jennifer J Lhost, Oriana E Hawkins, Kevin J Kunstman, Karl W Broman, Steven M Wolinsky, William H Hildebrand, David H O'Connor
BMC Immunology 2011, 12:39 (15 July 2011)
MHC class I expression varies dramatically among distinct leukocyte subsets of macaques but not in human cell subsets, suggesting pathogen tropism may impact the MHC class I restricted CD8+ T cell response focus in these primates.
Multidrug-resistance proteins are weak tumor associated antigens for colorectal carcinoma
Christina S Mullins, Sven Eisold, Ernst Klar, Michael Linnebacher
BMC Immunology 2011, 12:38 (10 July 2011)
SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation
Dejan Nikolic, Lindsay Calderon, Liqin Du, Steven R Post
BMC Immunology 2011, 12:37 (7 July 2011)
LabKey Server NAb: A tool for analyzing, visualizing and sharing results from neutralizing antibody assays
Britt Piehler, Elizabeth K Nelson, Josh Eckels, Sarah Ramsay, Karl Lum, Blake Wood, Kelli M Greene, Hongmei Gao, Michael S Seaman, David C Montefiori, Mark Igra
BMC Immunology 2011, 12:33 (27 May 2011)
Nitric oxide/cGMP pathway signaling actively down-regulates
α 4 β 1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion
Alexandre Chigaev, Yelena Smagley, Larry A Sklar
BMC Immunology 2011, 12:28 (17 May 2011)