- Simon R Carding, University of Leeds
- Lucienne Chatenoud, Hospital Necker
- Olivier Garraud, Institut National de la Transfusion Sanguine
- Catherine M Hawrylowicz, King's College London
- James Li, University of Hong Kong
- J Philip McCoy, National Institutes of Health
- Christopher Morrey, BioMed Central
Analysis of venous blood from sepsis patients suggests that an early decrease in gene expression of TREM-1 in monocytes is associated with poor outcome and a reciprocal decrease of the surface receptor TREM-1 linked with sepsis-induced immunosuppression may be part of the explanation.
Studies in primary CD4+ T cells from mice suggest that lipid raft-based membrane order is critical for clonal expansion of CD4+ T cells in response to a model peptide.
A novel web based application ImmunoGlobulin Galaxy (IGGalaxy) can analyze next-generation sequencing results and report immunoglobulin heavy chain (IHG) gene rearrangements for both repertoire and clonality studies.
Unique and common gene sets, pathways, immune system categories and functional clusters of genes in four autoimmune diseases suggest it is possible to develop molecular classifications of autoimmune and inflammatory events.
First generation microarray analysis of gene expression in the spleens of hamsters with progressive visceral leishmaniasis demonstrated a large number of highly upregulated genes and offers further insight into pathogenesis.
Sara Montagner, Lorenzo Dehó1 and Silvia MonticelliBMC Immunology 2014, 15:14 (31 March 2014)
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Section Editor's profile
Olivier Garraud is currently Professor of Immunology at the University of Lyon (the Faculty of Medicine of Saint-Etienne). Dr Garraud graduated as a physician and was trained in haematology and infectious diseases. He pursued his early career at the Institut Pasteur in Paris where he became involved with fundamental immunology. After more than a decade at the Institut Pasteur, Dr Garraud moved back to the field of medicine and was appointed the Executive Director of one of the 14 regional settings of the National Blood Service in France. Dr Garraud is currently supervising research programs focused on non-conventional B cell biology and platelet immunology in transfusion medicine but also in pathology, especially in infectious diseases such as sepsis, HIV infection and more generally in inflammation. Read more about his research interests in his recent review article.
"BMC Immunology is devoted to publishing high quality research in various directions in this fast growing discipline. We work hard to solicit the best possible reviewers and provide you with timely feedback in order to offer high visibility to important findings in the vast field of Immunology."