- Simon R Carding, University of Leeds
- Lucienne Chatenoud, Hospital Necker
- Olivier Garraud, Institut National de la Transfusion Sanguine
- Catherine M Hawrylowicz, King's College London
- James Li, University of Hong Kong
- J Philip McCoy, NIH
- Juan Carlos Zuniga-Pflucker, University of Toronto
- Christopher Morrey, BioMed Central
In vivo investigation of Salmonella Typhimurium infection in the mouse suggests a limited role for adapter protein ASC and cytosolic receptor NLRP3 despite the role attributed to the inflammasome in the host defense against bacteria.
Interferon-γ provides both inhibitory signals to block extensive proliferation and activating signals decreasing apoptosis as well as enhancing FcγRI expression and activation in human intestinal mast cells.
A prospective study suggests considerable variation in antibody levels to tetanus, diphtheria, varicella and measles measured in different batches of intravenous immunoglobulin from the same brand.
In vitro and in vivo data suggests that the use of immunobiotic strains like LjTL2937 as supplemental additives in piglet feedings may be an effective strategy to maintain and improve intestinal homeostasis.
Cytokine B-Cell Activating Factor may play a role in the strength of the antibody response to Ascaris lumbricoides as suggested by an inverse correlation of soluble BAFF with IgE.
Sara Montagner, Lorenzo Dehó1 and Silvia MonticelliBMC Immunology 2014, 15:14 (31 March 2014)
BMC Immunology 2014, 15:21
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BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.
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Section Editor's profile
Olivier Garraud is currently Professor of Immunology at the University of Lyon (the Faculty of Medicine of Saint-Etienne). Dr Garraud graduated as a physician and was trained in haematology and infectious diseases. He pursued his early career at the Institut Pasteur in Paris where he became involved with fundamental immunology. After more than a decade at the Institut Pasteur, Dr Garraud moved back to the field of medicine and was appointed the Executive Director of one of the 14 regional settings of the National Blood Service in France. Dr Garraud is currently supervising research programs focused on non-conventional B cell biology and platelet immunology in transfusion medicine but also in pathology, especially in infectious diseases such as sepsis, HIV infection and more generally in inflammation. Read more about his research interests in his recent review article.
"BMC Immunology is devoted to publishing high quality research in various directions in this fast growing discipline. We work hard to solicit the best possible reviewers and provide you with timely feedback in order to offer high visibility to important findings in the vast field of Immunology."