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Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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1.

Research article   Open Access

Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy

Mamoru Takada, Toru Higuchi, Katsunori Tozuka, Hiroyuki Takei, Masayuki Haruta, Junko Watanabe, Fumio Kasai, Kenichi Inoue, Masafumi Kurosumi, Masaru Miyazaki, Aiko Sato-Otsubo, Seishi Ogawa, Yasuhiko Kaneko BMC Cancer 2013, 13:241 (16 May 2013)

Abstract | Provisional PDF | PubMed

2.

Research article   Open Access

High CRP values predict poor survival in patients with penile cancer

Sandra Steffens, Andreas Al Ghazal, Julie Steinestel, Rieke Lehmann, Gerd Wegener, Thomas J Schnoeller, Marcus V Cronauer, Florian Jentzmik, Mark Schrader, Markus A Kuczyk, Andres J Schrader BMC Cancer 2013, 13:223 (3 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

3.

Research article   Open Access

Prognostic significance of peripheral monocyte count in patients with extranodal natural killer/T-cell lymphoma

Jia-Jia Huang, Ya-Jun Li, Yi Xia, Yu Wang, Wen-Xiao Wei, Ying-Jie Zhu, Tong-Yu Lin, Hui-Qiang Huang, Wen-Qi Jiang, Zhi-Ming Li BMC Cancer 2013, 13:222 (3 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

4.

Research article   Open Access

Human Papillomavirus-associated oropharyngeal cancer: an observational study of diagnosis, prevalence and prognosis in a UK population

Mererid Evans, Robert Newcombe, Alison Fiander, James Powell, Martin Rolles, Selvam Thavaraj, Max Robinson, Ned Powell BMC Cancer 2013, 13:220 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

5.

Research article   Open Access

A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer

Satoko Yamamoto, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Saori Fujiwara, Hirotaka Iwase BMC Cancer 2013, 13:217 (30 April 2013)

Abstract | Provisional PDF | PubMed

6.

Research article   Open Access

MicroRNA profile of paclitaxel-resistant serous ovarian carcinoma based on formalin-fixed paraffin-embedded samples

Xiao Li, Yaer Lu, Yaxia Chen, Weiguo Lu, Xing Xie BMC Cancer 2013, 13:216 (30 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

Research article   Open Access Highly Accessed

Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer - overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

Berit Maria Müller, Lisa Jana, Atsuko Kasajima, Annika Lehmann, Judith Prinzler, Jan Budczies, Klaus-Jürgen Winzer, Manfred Dietel, Wilko Weichert, Carsten Denkert BMC Cancer 2013, 13:215 (30 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

Research article   Open Access

Can selenium levels act as a marker of colorectal cancer risk?

Marcin R Lener, Satish Gupta, Rodney J Scott, Martin Tootsi, Maria Kulp, Mari-Liis Tammesoo, Anu Viitak, Anders Metspalu, Pablo Serrano-Fernández, Józef Kładny, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Magdalena Muszyńska, Grzegorz Sukiennicki, Anna Jakubowska, Jan Lubiński BMC Cancer 2013, 13:214 (29 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

Research article   Open Access

Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma

Chiharu Tabata, Eisuke Shibata, Rie Tabata, Shingo Kanemura, Koji Mikami, Yoshitaka Nogi, Eriko Masachika, Tomoyuki Nishizaki, Takashi Nakano BMC Cancer 2013, 13:205 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

Research article   Open Access Highly Accessed

Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker

Yi Liu, Qian Liu, Tao Wang, Li Bian, Shaohua Zhang, Haixu Hu, Sha Li, Zhiyuan Hu, Shikai Wu, Bing Liu, Zefei Jiang BMC Cancer 2013, 13:202 (23 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

11.

Research article   Open Access

Reduced mrna expression level of corticotropin-releasing hormone-binding protein is associated with aggressive human kidney cancer

Hossein Tezval, Faranaz Atschekzei, Inga Peters, Sandra Waalkes, Jörg Hennenlotter, Arnulf Stenzl, Jan U Becker, Axel S Merseburger, Markus A Kuczyk, Jürgen Serth BMC Cancer 2013, 13:199 (22 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

12.

Research article   Open Access

Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence

Bilal Alaiyan, Nadia Ilyayev, Alexander Stojadinovic, Mina Izadjoo, Marina Roistacher, Vera Pavlov, Victoria Tzivin, David Halle, Honguang Pan, Barry Trink, Ali O Gure, Aviram Nissan BMC Cancer 2013, 13:196 (17 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

13.

Research article   Open Access

High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression

Zhihua Shen, Xiaofan Jiang, Chao Zeng, Shaojiang Zheng, Botao Luo, Yumei Zeng, Ranran Ding, Hanguo Jiang, Qiyi He, Junli Guo, Wei Jie BMC Cancer 2013, 13:192 (15 April 2013)

Abstract | Full text | PDF | PubMed

14.

Research article   Open Access

Correlation of CD44v6 expression with ovarian cancer progression and recurrence

Jun Shi, Zhou Zhou, Wen Di, Ningli Li BMC Cancer 2013, 13:182 (8 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

15.

Research article   Open Access Highly Accessed

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1–3 is associated with reduced hyaluronan content in malignant cutaneous melanoma

Siiskonen Hanna, Poukka Mari, Tyynelä-Korhonen Kristiina, Sironen Reijo, Pasonen-Seppänen Sanna BMC Cancer 2013, 13:181 (5 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

16.

Research article   Open Access

Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer

Patrick C O¿Leary, Sarah Penny, Roisin T Dolan, Catherine M Kelly, Stephen F Madden, Elton Rexhepaj, Donal J Brennan, Amanda H McCann, Fredrik Pontén, Mathias Uhlén, Radoslaw Zagozdzon, Michael J Duffy, Malcolm R Kell, Karin Jirström, William M Gallagher BMC Cancer 2013, 13:175 (2 April 2013)

Abstract | Provisional PDF | PubMed

17.

Research article   Open Access

Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials

George Fountzilas, Urania Dafni, Mattheos Bobos, Vassiliki Kotoula, Anna Batistatou, Ioannis Xanthakis, Christos Papadimitriou, Ioannis Kostopoulos, Triantafillia Koletsa, Eleftheria Tsolaki, Despina Televantou, Eleni Timotheadou, Angelos Koutras, George Klouvas, Epaminontas Samantas, Nikolaos Pisanidis, Charisios Karanikiotis, Ioanna Sfakianaki, Nicholas Pavlidis, Helen Gogas, Helena Linardou, Konstantine T Kalogeras, Dimitrios Pectasides, Meletios A Dimopoulos BMC Cancer 2013, 13:163 (28 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

18.

Research article   Open Access

A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

Guang-Zhi Jin, Hui Dong, Wen-Long Yu, Yan Li, Xin-Yuan Lu, Hua Yu, Zhi-Hong Xian, Wei Dong, Yin-Kun Liu, Wen-Ming Cong, Meng-Chao Wu BMC Cancer 2013, 13:161 (27 March 2013)

Abstract | Full text | PDF | PubMed

19.

Research article   Open Access

53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19–9 in pancreatic adenocarcinoma

Natalie L Ausborn, Tong Wang, Sabrina C Wentz, Mary Kay Washington, Nipun B Merchant, Zhiguo Zhao, Yu Shyr, Anuradha Bapsi Chakravarthy, Fen Xia BMC Cancer 2013, 13:155 (26 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

20.

Research article   Open Access

Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop

Daniel Öhlund, Oskar Franklin, Erik Lundberg, Christina Lundin, Malin Sund BMC Cancer 2013, 13:154 (26 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

21.

Research article   Open Access

HP1γ expression is elevated in prostate cancer and is superior to Gleason score as a predictor of biochemical recurrence after radical prostatectomy

Jon Slezak, Matthew Truong, Wei Huang, David Jarrard BMC Cancer 2013, 13:148 (23 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

22.

Research article   Open Access

Snail1 expression in colorectal cancer and its correlation with clinical and pathological parameters

Feride Kroepil, Georg Fluegen, Daniel Vallböhmer, Stephan E Baldus, Levent Dizdar, Andreas M Raffel, Dieter Hafner, Nikolas H Stoecklein, Wolfram T Knoefel BMC Cancer 2013, 13:145 (22 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

23.

Research article   Open Access

Wdr66 is a novel marker for risk stratification and involved in epithelial-mesenchymal transition of esophageal squamous cell carcinoma

Qing Wang, Chenming Ma, Wolfgang Kemmner BMC Cancer 2013, 13:137 (21 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

24.

Research article   Open Access

Progress risk assessment of oral premalignant lesions with saliva miRNA analysis

Ya Yang, Yue-xiu Li, Xi Yang, Long Jiang, Zuo-jun Zhou, Ya-qin Zhu BMC Cancer 2013, 13:129 (19 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

25.

Research article   Open Access

αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma

Chantal van de Schootbrugge, Johan Bussink, Paul N Span, Fred CGJ Sweep, Reidar Grénman, Hanneke Stegeman, Ger JM Pruijn, Johannes HAM Kaanders, Wilbert C Boelens BMC Cancer 2013, 13:128 (18 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

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