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Genetics, genomics and epigenetics

This section considers articles on all aspects of genome-scale analysis, functional genomics, genetic association studies, pharmacogenomics and epigenetics in relation to cancer biology, diagnosis and therapy.

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131.

Research article   Open Access Highly Accessed

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

Meiju Ji, Haixia Guan, Cuixia Gao, Bingyin Shi, Peng Hou BMC Cancer 2011, 11:147 (20 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

132.

Research article   Open Access Highly Accessed

Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer

Chen-Yun Yeh, Shin-Mei Shin, Hsuan-Heng Yeh, Tsung-Jung Wu, Jyh-Wei Shin, Tsuey-Yu Chang, Giri Raghavaraju, Chung-Ta Lee, Jung-Hsien Chiang, Vincent S Tseng, Yuan-Chii G Lee, Cheng-Huang Shen, Nan-Haw Chow, Hsiao-Sheng Liu BMC Cancer 2011, 11:139 (16 April 2011)

Abstract | Full text | PDF | PubMed

133.

Research article   Open Access

Detection of erbB2 copy number variations in plasma of patients with esophageal carcinoma

Immacolata Andolfo, Giuseppe Petrosino, Loredana Vecchione, Pasqualino De Antonellis, Mario Capasso, Donatella Montanaro, Marica Gemei, Giancarlo Troncone, Achille Iolascon, Michele Orditura, Fortunato Ciardiello, Fernando De Vita, Massimo Zollo BMC Cancer 2011, 11:126 (11 April 2011)

Abstract | Full text | PDF | PubMed

134.

Research article   Open Access

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart, Mark J Arends BMC Cancer 2011, 11:123 (7 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

135.

Research article   Open Access

Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer

Akira Ooki, Keishi Yamashita, Shiro Kikuchi, Shinichi Sakuramoto, Natsuya Katada, Mina Waraya, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura, Masahiko Watanabe BMC Cancer 2011, 11:122 (6 April 2011)

Abstract | Full text | PDF | PubMed

136.

Research article   Open Access

Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential

Yong Li, Zhuoma Basang, Huirong Ding, Zheming Lu, Tao Ning, Haoran Wei, Hong Cai, Yang Ke BMC Cancer 2011, 11:121 (6 April 2011)

Abstract | Full text | PDF | PubMed

137.

Research article   Open Access

A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival

Jyotsna Batra, Christina M Nagle, Tracy O'Mara, Melanie Higgins, Ying Dong, Olivia L Tan, Felicity Lose, Lene Skeie, Srilakshmi Srinivasan, Kelly L Bolton, Honglin Song, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Mary-Anne Kedda, Amanda B Spurdle, Judith A Clements BMC Cancer 2011, 11:119 (1 April 2011)

Abstract | Full text | PDF | PubMed

138.

Research article   Open Access

A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population

Keke Zhou, Dezhi Hu, Juan Lu, Weiwei Fan, Hongliang Liu, Hongyan Chen, Gong Chen, Qingyi Wei, Guhong Du, Ying Mao, Daru Lu, Liangfu Zhou BMC Cancer 2011, 11:104 (23 March 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

139.

Research article   Open Access Highly Accessed

Correlation of SHOX2 Gene Amplification and DNA Methylation in Lung Cancer Tumors

Katja U Schneider, Dimo Dietrich, Michael Fleischhacker, Gunda Leschber, Johannes Merk, Frank Schäper, Henk R Stapert, Erik R Vossenaar, Sabine Weickmann, Volker Liebenberg, Christoph Kneip, Anke Seegebarth, Fikret Erdogan, Gudrun Rappold, Bernd Schmidt BMC Cancer 2011, 11:102 (22 March 2011)

Abstract | Full text | PDF | PubMed

140.

Research article   Open Access Highly Accessed

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer

Genni M Newnham, Matthew Conron, SueAnne McLachlan, Alexander Dobrovic, Hongdo Do, Jason Li, Kenneth Opeskin, Natalie Thompson, Gavin M Wright, David M Thomas BMC Cancer 2011, 11:93 (7 March 2011)

Abstract | Full text | PDF | PubMed

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