BMC Cancer | Experimental therapeutics and drug development section

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Experimental therapeutics and drug development

This section covers all aspects of preclinical investigations on therapeutic agents. It welcomes submissions concerning anti-cancer drug discovery and development, and targeted therapies.

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	1.	Research article IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma Marieke L Kuijjer, Elisabeth FP Peterse, Brendy EWM van den Akker, Inge H Briaire-de Bruijn, Massimo Serra, Leonardo A Meza-Zepeda, Ola Myklebost, A Bassim Hassan, Pancras CW Hogendoorn, Anne-Marie Cleton-Jansen BMC Cancer 2013, 13:245 (20 May 2013) Abstract \| Provisional PDF
	2.	Research article Equol enhances tamoxifen's anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells Christiana Charalambous, Chara A Pitta, Andreas I Constantinou BMC Cancer 2013, 13:238 (15 May 2013) Abstract \| Provisional PDF \| PubMed
	3.	Research article Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells Mamoru Tanaka, Hiromi Kataoka, Shigenobu Yano, Hiromi Ohi, Keisuke Kawamoto, Takashi Shibahara, Tsutomu Mizoshita, Yoshinori Mori, Satoshi Tanida, Takeshi Kamiya, Takashi Joh BMC Cancer 2013, 13:237 (14 May 2013) Abstract \| Full text \| PDF \| PubMed
	4.	Research article Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells Naoko Yamagishi, Shigetada Teshima-Kondo, Kiyoshi Masuda, Kensei Nishida, Yuki Kuwano, Duyen T Dang, Long H Dang, Takeshi Nikawa, Kazuhito Rokutan BMC Cancer 2013, 13:229 (7 May 2013) Abstract \| Full text \| PDF \| PubMed
	5.	Research article Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β Jun Ohishi, Mikiko Aoki, Kazuki Nabeshima, Junji Suzumiya, Tamotsu Takeuchi, Akira Ogose, Michiyuki Hakozaki, Yuichi Yamashita, Hiroshi Iwasaki BMC Cancer 2013, 13:224 (4 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	6.	Research article Evaluation of hypoxia in a feline model of head and neck cancer using 64Cu-ATSM positron emission tomography/computed tomography Elizabeth A Ballegeer, Nicole J Madrill, Kevin L Berger, Dalen W Agnew, Elizabeth A McNiel BMC Cancer 2013, 13:218 (30 April 2013) Abstract \| Provisional PDF \| PubMed
	7.	Research article Evidence for tankyrases as antineoplastic targets in lung cancer Alexander M Busch, Kevin C Johnson, Radu V Stan, Aarti Sanglikar, Yashi Ahmed, Ethan Dmitrovsky, Sarah J Freemantle BMC Cancer 2013, 13:211 (28 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	8.	Research article In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells Drazen B Zimonjic, Lai N Chan, Veenu Tripathi, Jie Lu, Ohyun Kwon, Nicholas C Popescu, Douglas R Lowy, Fuyuhiko Tamanoi BMC Cancer 2013, 13:198 (22 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	9.	Research article A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy Tracy R Daniels-Wells, Gustavo Helguera, Richard K Leuchter, Rafaela Quintero, Maggie Kozman, José A Rodríguez, Elizabeth Ortiz-Sánchez, Otoniel Martínez-Maza, Birgit C Schultes, Christopher F Nicodemus, Manuel L Penichet BMC Cancer 2013, 13:195 (17 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	10.	Research article Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer Michele T Yip-Schneider, Huangbing Wu, Keith Stantz, Narasimhan Agaram, Peter A Crooks, C Max Schmidt BMC Cancer 2013, 13:194 (17 April 2013) Abstract \| Provisional PDF \| PubMed
	11.	Research article Radiation mitigating properties of the lignan component in flaxseed Ralph Pietrofesa, Jason Turowski, Sonia Tyagi, Floyd Dukes, Evguenia Arguiri, Theresa M Busch, Shannon M Gallagher-Colombo, Charalambos C Solomides, Keith A Cengel, Melpo Christofidou-Solomidou BMC Cancer 2013, 13:179 (4 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	12.	Research article Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro Thomas M Cardillo, Preeti Trisal, Roberto Arrojo, David M Goldenberg, Chien-Hsing Chang BMC Cancer 2013, 13:170 (1 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	13.	Research article [18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice Mette Munk Jensen, Kamille Dumong Erichsen, Camilla Bardram Johnbeck, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Maxwell Sehested, Liselotte Højgaard, Andreas Kjær BMC Cancer 2013, 13:168 (1 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	14.	Research article The combination of ANT2 shRNA and hNIS radioiodine gene therapy increases CTL cytotoxic activity through the phenotypic modulation of cancer cells: combination treatment with ANT2 shRNA and I-131 Yun Choi, Ho Won Lee, Jaetae Lee, Yong Hyun Jeon BMC Cancer 2013, 13:143 (22 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	15.	Research article TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages Bao-Zhu Yuan, Joshua Chapman, Ming Ding, Junzhi Wang, Binghua Jiang, Yon Rojanasakul, Steven H Reynolds BMC Cancer 2013, 13:140 (22 March 2013) Abstract \| Provisional PDF \| PubMed
	16.	Study protocol Early-stage squamous cell carcinoma of the oropharynx: Radiotherapy vs. Trans-Oral Robotic Surgery (ORATOR) – study protocol for a randomized phase II trial Anthony C Nichols, John Yoo, J Alex Hammond, Kevin Fung, Eric Winquist, Nancy Read, Varagur Venkatesan, S Danielle MacNeil, D Scott Ernst, Sara Kuruvilla, Jeff Chen, Martin Corsten, Michael Odell, Libni Eapen, Julie Theurer, Philip C Doyle, Bret Wehrli, Keith Kwan, David A Palma BMC Cancer 2013, 13:133 (20 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	17.	Technical advance Development of a novel cell-based assay system EPISSAY for screening epigenetic drugs and liposome formulated decitabine Sue Ping Lim, Raman Kumar, Yamini Akkamsetty, Wen Wang, Kristen Ho, Paul M Neilsen, Diego J Walther, Rachel J Suetani, Clive Prestidge, David F Callen BMC Cancer 2013, 13:113 (13 March 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	18.	Research article The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption Hironobu Yasui, Taketoshi Asanuma, Junichi Kino, Tohru Yamamori, Shunsuke Meike, Masaki Nagane, Nobuo Kubota, Mikinori Kuwabara, Osamu Inanami BMC Cancer 2013, 13:106 (8 March 2013) Abstract \| Full text \| PDF \| PubMed
	19.	Research article Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice Anahid Ehteda, Peter Galettis, Krishna Pillai, David L Morris BMC Cancer 2013, 13:86 (23 February 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	20.	Research article Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies Ian M Zitron, Archana Thakur, Oxana Norkina, Geoffrey R Barger, Lawrence G Lum, Sandeep Mittal BMC Cancer 2013, 13:83 (22 February 2013) Abstract \| Full text \| PDF \| PubMed
	21.	Research article Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14 Liduan Zheng, Dan Li, Xuan Xiang, Ling Tong, Meng Qi, Jiarui Pu, Kai Huang, Qiangsong Tong BMC Cancer 2013, 13:74 (10 February 2013) Abstract \| Full text \| PDF \| PubMed
	22.	Research article Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh, Helmout Modjtahedi BMC Cancer 2013, 13:41 (31 January 2013) Abstract \| Full text \| PDF \| PubMed
	23.	Research article Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma Ales Sedlar, Simona Kranjc, Tanja Dolinsek, Maja Cemazar, Andrej Coer, Gregor Sersa BMC Cancer 2013, 13:38 (29 January 2013) Abstract \| Full text \| PDF \| PubMed
	24.	Research article Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamics BreeAnn N Brandhagen, Chelsea R Tieszen, Tara M Ulmer, Maria S Tracy, Alicia A Goyeneche, Carlos M Telleria BMC Cancer 2013, 13:35 (26 January 2013) Abstract \| Full text \| PDF \| PubMed
	25.	Research article Preclinical evaluation of Sunitinib as a single agent in the prophylactic setting in a mouse model of bone metastases Christian Schem, Dirk Bauerschlag, Sascha Bender, Ann-Christin Lorenzen, Daniel Loermann, Sigrid Hamann, Frank Rösel, Holger Kalthoff, Claus C Glüer, Walter Jonat, Sanjay Tiwari BMC Cancer 2013, 13:32 (24 January 2013) Abstract \| Full text \| PDF \| PubMed