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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor J. Ann Le Good, PhD
Welcome to BMC Biotechnology published by BioMed Central
BMC Biotechnology is an open access journal publishing original peer-reviewed research articles in the manipulation of biological macromolecules or organisms for use in experimental procedures, cellular and tissue engineering or in the pharmaceutical, agricultural biotechnology and allied industries.
BMC Biotechnology (ISSN 1472-6750) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Thomson Reuters (ISI) and Google Scholar.
BMC Biotechnology 2009, 9 :50
A creative application of high resolution melt curve analysis enables rapid visualization of the clonal diversity of phage selected from an antibody display library, providing a time and cost-efficient method of grouping identical clones prior to sequence analysis.
BMC Biotechnology 2009, 9 :48
Modified peroxisomes, decorated with golgi-derived v-SNARE molecules, may be used to re-route intracellular vesicle trafficking, enabling the secretion of intracellular proteins with potentially useful industrial biotechnology applications.
BMC Biotechnology 2009, 9 :22
The efficient production of biologically-active murine and viral Interleukin-10 (IL-10) in transgenic tobacco paves the way for oral administration of this anti-inflammatory cytokine in animal studies of autoimmune disease.
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Methodology article
Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies Oded Edelheit, Aaron Hanukoglu, Israel Hanukoglu BMC Biotechnology 2009, 9 :61 (30 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity Thibaut Pelat, Michael Hust, Martha Hale, Marie-Paule Lefranc, Stefan Dubel, Philippe Thullier BMC Biotechnology 2009, 9 :60 (30 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Novel sequential ChIP and simplified basic ChIP protocols for promoter co-occupancy and target gene identification in human embryonic stem cells Ricardo B Medeiros, Kate J Papenfuss, Brian Hoium, Kristen Coley, Joy Jadrich, Saik-Kia Goh, Anuratha Elayaperumal, Julio E Herrera, Ernesto Resnik, Hsiao-Tzu Ni BMC Biotechnology 2009, 9 :59 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Cell-free protein synthesis energized by slowly-metabolized maltodextrin Yiran Wang, Y-H. Percival Zhang BMC Biotechnology 2009, 9 :58 (28 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Interfering ribonucleic acids that suppress expression of multiple unrelated genes Toby Passioura, Mary M Gozar, Amber Goodchild, Andrew King, Greg M Arndt, Michael Poidinger, Donald J Birkett, Laurent P Rivory BMC Biotechnology 2009, 9 :57 (16 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Expression of endo-1, 4-beta-xylanase from Trichoderma reesei in Pichia pastoris and functional characterization of the produced enzyme Jun He, Bing Yu, Keying Zhang, Xuemei Ding, Daiwen Chen BMC Biotechnology 2009, 9 :56 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
High-titer preparation of Bombyx mori nucleopolyhedrovirus (BmNPV) displaying recombinant protein in silkworm larvae by size exclusion chromatography and its characterization Tatsuya Kato, Suganthi Lavender Manoha, Shigeyasu Tanaka, Enoch Y Park BMC Biotechnology 2009, 9 :55 (12 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Synthesis of sialoglycopolypeptide for potentially blocking influenza virus infection using a rat Makoto Ogata, Makoto Nakajima, Tatsuya Kato, Takakiyo Obara, Hirokazu Yagi, Koichi Kato, Taichi Usui, Enoch Y Park BMC Biotechnology 2009, 9 :54 (5 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Construction of siRNA/miRNA expression vectors based on a one-step PCR process Jun Xu, Jie Qiong Zeng, Gang Wan, Gui Bin Hu, Hong Yan, Li Xin Ma BMC Biotechnology 2009, 9 :53 (2 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Integrated application of uniform design and least-squares support vector machines to transfection optimization Jin-Shui Pan, Mei-Zhu Hong, Qi-Feng Zhou, Jia-Yan Cai, Hua-Zhen Wang, Lin-Kai Luo, De-Qiang Yang, Jing Dong, Hua-Xiu Shi, Jian-Lin Ren BMC Biotechnology 2009, 9 :52 (31 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
How can accelerated development of bioenergy contribute to the future UK energy mix? Insights from a MARKAL modelling exercise Donna Clarke, Sophie Jablonski, Brighid Moran, Gabrial Anandarajah, Gail Taylor Biotechnology for Biofuels 2009, 2 :13 (3 [Abstract ] [Provisional PDF ]
Methodology
Development of a gene silencing DNA vector derived from a broad host range geminivirus Edward M Golenberg, D NOAH Sather, Leandria C Hancock, Kenneth J Buckley, Natalie M Villafranco, David M Bisaro Plant Methods 2009, 5 :9 (2 [Abstract ] [Provisional PDF ]
Research article
Selection of reference genes for quantitative real time PCR expression studies in the apomictic and sexual grass Brachiaria brizantha Erica DUARTE Silveira, Marcio Alves-Ferreira, Larissa ARRAIS Guimaraes, Felipe RODRIGUES da Silva, Vera TAVARES DE CAMPOS Carneiro BMC Plant Biology 2009, 9 :84 (2 [Abstract ] [Provisional PDF ]
Research article
The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies Philippos A Papathanos, Nikolai Windbichler, Miriam Menichelli, Austin Burt, Andrea Crisanti BMC Molecular Biology 2009, 10 :65 (2 [Abstract ] [Provisional PDF ]
Research
Developing a scalable model of recombinant protein yield from Pichia pastoris: the influence of culture conditions, biomass and induction regime William J Holmes, Richard AJ Darby, Martin DB Wilks, Rodney Smith, Roslyn M Bill Microbial Cell Factories 2009, 8 :35 (1 [Abstract ] [Provisional PDF ]
Research article
NLStradamus: a simple Hidden Markov Model for nuclear localization signal prediction Alex N Nguyen Ba, Anastassia Pogoutse, Nicholas Provart, Alan M Moses BMC Bioinformatics 2009, 10 :202 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Triangle network motifs predict complexes by complementing high-error interactomes with structural information Bill Andreopoulos, Christof Winter, Dirk Labudde, Michael Schroeder BMC Bioinformatics 2009, 10 :196 (27 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Agrobacterium rhizogenes-mediated transformation of Superroot-derived Lotus corniculatus plants: a valuable tool for functional genomics Bo Jian, Wensheng Hou, Cunxiang Wu, Bin Liu, Wei Liu, Shikui Song, Yurong Bi, Tianfu Han BMC Plant Biology 2009, 9 :78 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Computational analysis of the interaction between transcription factors and the predicted secreted proteome of the yeast Kluyveromyces lactis Otavio JB Brustolini, Luciano G Fietto, Cosme D Cruz, Flavia ML Passos BMC Bioinformatics 2009, 10 :194 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Review
Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review Ajay KUMAR Chaudhary, Mamta Singh, Shanthy Sundaram, Ravi Mehrotra Head & Neck Oncology 2009, 1 :22 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
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