Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease
BMC Biology 2013, 11:100 (30 September 2013)
Genetic background affects the age of onset and severity of human disease caused by protein-destabilizing mutations. Now variation has been found between wild strains of C. elegans in the toxicity of polyglutamine expansion, suggesting multiple paths to the expression of toxicity, and multiple natural genetic modifiers of potential therapeutic relevance.
Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum
BMC Biology 2013, 11:67 (13 June 2013)
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Metabolism, diet and...
A reassessment of the carbon metabolism of Plasmodium falciparum challenges previous findings and suggests new therapeutic opportunities.