BMC Biology | Most Viewed

Submit a manuscript Register Contact us Follow us on Twitter

Explore BMC Biology

Advertisement

Articles

Display/download options Articles per page: 25 | 50 | 100

Display options

Editor's summary Citation

Download options

Send
To

	All
	76. 11093 Accesses	Research article Classification of human breathing sounds by the common vampire bat, Desmodus rotundus Udo Gröger, Lutz Wiegrebe BMC Biology 2006, 4:18 (16 June 2006) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Vampire bats can recognize individual humans from the sound of their breathing, and may use this cue to select the same prey on different nights.
	77. 11069 Accesses	Research article Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D₃receptor Jeffrey N Joyce, Cheryl Woolsey, Han Ryoo, Sabine Borwege, Diane Hagner BMC Biology 2004, 2:22 (11 October 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Low doses of pramipexole protect against MPTP-induced dopamine neuron and fibre loss in a Parkinson's disease mouse model, probably acting via the D3 receptor to downregulate the dopamine transporter.
	78. 10972 Accesses	Question and Answer Q&A: Single-molecule localization microscopy for biological imaging Ann L McEvoy, Derek Greenfield, Mark Bates, Jan Liphardt BMC Biology 2010, 8:106 (11 August 2010) Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary In Q&A format, Ann McEvoy, Jan Liphardt and colleagues explain the principles of single-molecule localization microscopy and how it can be used for understanding cell biology
	79. 10804 Accesses	Methodology article The vertebrate phylotypic stage and an early bilaterian-related stage in mouse embryogenesis defined by genomic information Naoki Irie, Atsuko Sehara-Fujisawa BMC Biology 2007, 5:1 (12 January 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A new genetic method reveals that during development the mouse passes through an evolutionarily constrained embryonic period corresponding to the much debated phylotypic stage that represents maximum resemblance among various vertebrates.
	80. 10756 Accesses	Research article The complete chloroplast DNA sequences of the charophycean green algae Staurastrum and Zygnema reveal that the chloroplast genome underwent extensive changes during the evolution of the Zygnematales Monique Turmel, Christian Otis, Claude Lemieux BMC Biology 2005, 3:22 (20 October 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Despite the considerable differences found between the chloroplast genomes of two Zygnematales green algae, their characteristics suggest that most of the typical features of land plant chloroplast genomes were already present in the last common ancestor of these two species.
	81. 10750 Accesses	Correspondence Video analysis of the escape flight of Pileated Woodpecker Dryocopus pileatus: does the Ivory-billed Woodpecker Campephilus principalis persist in continental North America? J Martin Collinson BMC Biology 2007, 5:8 (15 March 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 3 comments \| Editor’s summary A video showing the otherwise extinct Arkansas Ivory-billed Woodpecker may actually depict a Pileated Woodpecker, as this common woodpecker has a wingbeat frequency during escape flight matching that of the bird in the video.
	82. 10732 Accesses	Research article Rise of oceanographic barriers in continuous populations of a cetacean: the genetic structure of harbour porpoises in Old World waters Michaël C Fontaine, Stuart JE Baird, Sylvain Piry, Nicolas Ray, Krystal A Tolley, Sarah Duke, Alexei Birkun, Marisa Ferreira, Thierry Jauniaux, Ángela Llavona, Bayram Öztürk, Ayaka A Öztürk, Vincent Ridoux, Emer Rogan, Marina Sequeira, Ursula Siebert, Gísli A Vikingsson, Jean-Marie Bouquegneau, Johan R Michaux BMC Biology 2007, 5:30 (25 July 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Oceanographic features, such as temperature and chlorophyll concentration, can constrain dispersal of harbour porpoises in a seemingly continuous marine environment, with gene flow indicating the genetic isolation of populations in some locations.
	83. 10582 Accesses	Research article Complete reannotation of the Arabidopsis genome: methods, tools, protocols and the final release Brian J Haas, Jennifer R Wortman, Catherine M Ronning, Linda I Hannick, Roger K Smith, Rama Maiti, Agnes P Chan, Chunhui Yu, Maryam Farzad, Dongying Wu, Owen White, Christopher D Town BMC Biology 2005, 3:7 (22 March 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The TIGR group explain how they reannotated the Arabidopsis genome, with several thousand new genes and pseudogenes annotated, 1/3 of the original annotations refined and every protein-coding gene assigned to a Gene Ontology term.
	84. 10553 Accesses	Research article A mutation in the centriole-associated protein centrin causes genomic instability via increased chromosome loss in Chlamydomonas reinhardtii Ivan Zamora, Wallace F Marshall BMC Biology 2005, 3:15 (31 May 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In the green alga Chlamydomonas, mutations in the centriole-associated protein, centrin, that lead to acentriolar bipolar spindles cause increased genomic instability, as measured by loss of heterozygosity, suggesting a role for centrin in mitotic fidelity.
	85. 10536 Accesses	Research article Classification and nomenclature of all human homeobox genes Peter WH Holland, H Booth, Elspeth A Bruford BMC Biology 2007, 5:47 (26 October 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comprehensive survey of human homeobox genes and pseudogenes has discovered previously unknown loci, leading to a revised classification of homeobox genes using names that reflect their evolutionary relationships to other loci.
	86. 10407 Accesses	Editorial Plus ça change Miranda Robertson BMC Biology 2010, 8:44 (12 April 2010) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The fusion of BMC Biology and Journal of Biology offers the best of both, with hybrid vigor.
	87. 10348 Accesses	Research article Systematic comparison and reconstruction of sea urchin (Echinoidea) internal anatomy: a novel approach using magnetic resonance imaging Alexander Ziegler, Cornelius Faber, Susanne Mueller, Thomas Bartolomaeus BMC Biology 2008, 6:33 (23 July 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Three-dimensional reconstructions of the internal anatomy of sea urchins using high-field magnetic resonance images provides rapid non-destructive insights into the morphology of museum specimens.
	88. 10301 Accesses	Commentary Anaerobic animals from an ancient, anoxic ecological niche Marek Mentel, William Martin BMC Biology 2010, 8:32 (6 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Marek Mentel and William Martin argue that the tiny anoxic animals reported by Danovaro et al, with their hydrogenosome-like organelles, are relevant to metazoan evolution before the rise of deep marine oxygen levels, about 550-600 million years ago.
	89. 10240 Accesses	Research article A comprehensive functional analysis of tissue specificity of human gene expression Zoltán Dezső, Yuri Nikolsky, Evgeny Sviridov, Weiwei Shi, Tatiana Serebriyskaya, Damir Dosymbekov, Andrej Bugrim, Eugene Rakhmatulin, Richard J Brennan, Alexey Guryanov, Kelly Li, Julie Blake, Raymond R Samaha, Tatiana Nikolskaya BMC Biology 2008, 6:49 (12 November 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The biological function of ubiquitously-expressed house-keeping and tissue-specific genes is consistent with tissue origin and tissue signature networks promise to be a rich source of targets for disease treatment and diagnosis.
	90. 10173 Accesses	Research article Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin Markus Almén, Karl JV Nordström, Robert Fredriksson, Helgi B Schiöth BMC Biology 2009, 7:50 (13 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Of the total human proteome 27% are alpha-helical transmembrane proteins, with 59% classified into 234 families of receptors, transporters, enzymes or 74 novel groups, and 41% being single genes with no clear identity.
	91. 10169 Accesses	Research article How many novel eukaryotic 'kingdoms'? Pitfalls and limitations of environmental DNA surveys Cédric Berney, José Fahrni, Jan Pawlowski BMC Biology 2004, 2:13 (4 June 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A survey of kingdom level diversity in eukaryotes based on environmental DNA shows that previous estimates have been exaggerated due to chimeric sequences and the misplacement of fast evolving sequences.
	92. 10169 Accesses	Review Immune mechanisms of protection: can adjuvants rise to the challenge? Amy S McKee, Megan KL MacLeod, John W Kappler, Philippa Marrack BMC Biology 2010, 8:37 (12 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vaccines require adjuvants to stimulate the immune system. For diseases for which no effective vaccine exists, advances in the understanding of adjuvants will be crucial.
	93. 10049 Accesses	Methodology article Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy Phillip Hundeshagen, Anne Hamacher-Brady, Roland Eils, Nathan R Brady BMC Biology 2011, 9:38 (2 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary There is much interest in activating autophagy, by which cells deliver their own contents to the lysosomal system, in cancer therapy. Nathan Brady and colleagues report a flow cytometric method whereby drug candidates may be screened for effects on separate steps in the process.
	94. 10031 Accesses	Research article Regeneration and reprogramming compared Bea Christen, Vanesa Robles, Marina Raya, Ida Paramonov, Juan Belmonte BMC Biology 2010, 8:5 (20 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Key pluripotency-associated factors, whose overexpression can drive somatic cells to reprogram as pluripotent stem cells, are also required for appendage regeneration in fish and amphibians.
	95. 9995 Accesses	Research article Left hemispheric dominance during auditory processing in a noisy environment Hidehiko Okamoto, Henning Stracke, Bernhard Ross, Ryusuke Kakigi, Christo Pantev BMC Biology 2007, 5:52 (15 November 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The left hemisphere of the brain does more work than the right side when distinguishing distinct sounds from background noise in noisy environments, an ability essential for understanding speech in the 'cocktail-party effect'.
	96. 9936 Accesses	Research article Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development Kristopher R Schwab, Larry T Patterson, Heather A Hartman, Ni Song, Richard A Lang, Xinhua Lin, S Steven Potter BMC Biology 2007, 5:15 (10 April 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary In a striking shift away from the critical role the pygopus gene takes in fruit fly development, Pygo mutations in mice cause only mild kidney defects, reflecting a minor 'modulating' role in mammals.
	97. 9841 Accesses	Research article Hue-shifted monomeric variants of Clavularia cyan fluorescent protein: identification of the molecular determinants of color and applications in fluorescence imaging Hui-wang Ai, Scott G Olenych, Peter Wong, Michael W Davidson, Robert E Campbell BMC Biology 2008, 6:13 (6 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary A novel teal fluorescent protein, mWasabi, is useful for two-color imaging and fluorescence resonance energy transfer studies because two mutations near the chromophore bestow narrow spectral properties and resistance to violet light excitation.
	98. 9815 Accesses	Software MochiView: versatile software for genome browsing and DNA motif analysis Oliver R Homann, Alexander D Johnson BMC Biology 2010, 8:49 (21 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new software tool, MochiView, integrates browsing of genomic sequences with DNA motif visualization which is particularly useful for organizing and analyzing large genomic data sets.
	99. 9792 Accesses	Research article 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus Jacob G Bundy, Jasmin K Sidhu, Faisal Rana, David J Spurgeon, Claus Svendsen, Jodie F Wren, Stephen R Stürzenbaum, A John Morgan, Peter Kille BMC Biology 2008, 6:25 (3 June 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The toxic effects of chemical contaminants like copper on a key indicator organism, the earthworm, can be monitored by combining metabolomics and transcriptomics, a systems ecotoxicology approach that provides detailed molecular information about adaptation to soil pollutants.
	100. 9779 Accesses	Research article Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins Stanley M Gartler, Kartik R Varadarajan, Ping Luo, Theresa K Canfield, Jeff Traynor, Uta Francke, R Scott Hansen BMC Biology 2004, 2:21 (20 September 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Although in ICF syndrome cells the inactive X chromosome is hypomethylated, there is normal histone modification, suggesting that DNA methylation is not critical to histone modification: Rett syndrome cell data support this view.