2011 July

Novel regulators of cell morphology and migration

Results from a RNA interference (RNAi) screen for human regulators of the cytoskeleton show that disruption of expression of the formin family member diaphanous homolog 1 (DIAPH1) leads to very elongated cells with long processes and narrow membrane extensions containing microtubules (green) in prostate cancer-derived cells (PC3 cells). Cytoskeletal F-actin (red) and nuclei (blue) were visualized. DIAPH1 was identified from an RNAi screen in Drosophila melanogaster S2R+ cells that characterized 26 novel human genes as regulators of cytoskeletal organization.

Taken from: Anne Ridley et al., 2011, BMC Biology [View article]

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