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		Commentary Endothelio-hematopoietic relationship: getting closer to the beginnings Sabrina Gordon-Keylock, Alexander Medvinsky BMC Biology 2011, 9:88 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Both blood cells and vascular cells can differentiate from a single precursor cell, the hemangioblast. But what is the origin of the hemangioblast? Gordon-Keylock and Medvinsky discuss a new method of labeling these cells, reported by Ana T Tavares and colleagues, that may provide an answer.
		Research article Multiple origins of endosymbiosis within the Enterobacteriaceae (γ-Proteobacteria): convergence of complex phylogenetic approaches Filip Husník, Tomáš Chrudimský, Václav Hypša BMC Biology 2011, 9:87 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Symbiosis is assumed to be a rare event, but a sophisticated evolutionary analysis picks apart the history of endosymbiosis between bacteria and insects and shows that in contrast to a single origin, symbiosis in this context has independently evolved a number of times.
		Correction The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA Philipp Kapranov, Georges St Laurent, Tal Raz, Fatih Ozsolak, C Patrick Reynolds, Poul HB Sorensen, Gregory Reaman, Patrice Milos, Robert J Arceci, John F Thompson, Timothy J Triche BMC Biology 2011, 9:86 (20 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Putting the pH into phosphatidic acid signaling John JH Shin, Christopher JR Loewen BMC Biology 2011, 9:85 (2 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary John Shin and Christopher Loewen explain how the unique properties of phosphatidic acid may equip it to act as a pH biosensor in the lipid membrane of cells, and review the emerging evidence that lipids monitor and respond to changes in cellular pH.
		Editorial Pit-bull reviewing, the pursuit of perfection and the victims of success Miranda Robertson BMC Biology 2011, 9:84 (1 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The festering discontent with reviewing and editorial practices in the high-profile biology journals has erupted into a new high-quality open access journal to be launched in 2012. Miranda Robertson explores the problem and the solutions offered, and revisits the re-review opt-out policy operated by BMC Biology.
		Research article Notch1 binds and induces degradation of Snail in hepatocellular carcinoma Seung-Oe Lim, Hyeon Kim, Xiaoyuan Quan, Sun-Min Ahn, Hongtae Kim, David Hsieh, Je Kyung Seong, Guhung Jung BMC Biology 2011, 9:83 (30 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth Lucas P Carlstrom, Jacob H Hines, Steven J Henle, John R Henley BMC Biology 2011, 9:82 (30 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Motion dazzle and camouflage as distinct anti-predator defenses Martin Stevens, W Tom L Searle, Jenny E Seymour, Kate LA Marshall, Graeme D Ruxton BMC Biology 2011, 9:81 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements Morten Rye, Pål Sætrom, Tony Håndstad, Finn Drabløs BMC Biology 2011, 9:80 (24 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary How plants cope with temperature stress Virginia Walbot BMC Biology 2011, 9:79 (17 November 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial Genes, animal models and the current understanding of psychiatric disease Penelope Austin BMC Biology 2011, 9:78 (11 November 2011) Full text \| PDF \| PubMed \| Editor’s summary Two articles in our Wiring the Brain series explore the implications of new genetic information on psychiatric disease for clinical practice and for elucidation of the complex biology of disorders of the mind. Penelope Austin explains the two points of view they reflect.
		Opinion Two patients walk into a clinic...a genomics perspective on the future of schizophrenia Aiden P Corvin BMC Biology 2011, 9:77 (11 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary How will progress in understanding genetic susceptibility to schizophrenia affect patients? Aiden Corvin suggests that it will not continue to be viewed as a single disease, and that diagnosis and treatment will be transformed.
		Review Following the genes: a framework for animal modeling of psychiatric disorders Kevin J Mitchell, Z Josh Huang, Bita Moghaddam, Akira Sawa BMC Biology 2011, 9:76 (11 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Following a brief overview of the revolution in psychiatric genetics, Kevin Mitchell and colleagues explain how the effects of causal mutations can be studied in animals to elucidate pathogenic mechanisms and neurobiological phenotypes of direct relevance to human disease.
		Research article Requirement for Pdx1 in specification of latent endocrine progenitors in zebrafish Robin A Kimmel, Lucas Onder, Armin Wilfinger, Elin Ellertsdottir, Dirk Meyer BMC Biology 2011, 9:75 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Sumo-dependent substrate targeting of the SUMO protease Ulp1 Zachary C Elmore, Megan Donaher, Brooke C Matson, Helen Murphy, Jason W Westerbeck, Oliver Kerscher BMC Biology 2011, 9:74 (28 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The docking protein p130Cas regulates cell sensitivity to proteasome inhibition Ming Zhao, Kristiina Vuori BMC Biology 2011, 9:73 (28 October 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas Dharminder Chauhan, Kenneth C Anderson BMC Biology 2011, 9:72 (28 October 2011) Abstract \| Full text \| PDF \| PubMed
		Review Molecular dynamics simulations and drug discovery Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.
		Research article Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast Karin Lanthaler, Elizabeth Bilsland, Paul D Dobson, Harry J Moss, Pınar Pir, Douglas B Kell, Stephen G Oliver BMC Biology 2011, 9:70 (24 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors Alfredo Csibi, John Blenis BMC Biology 2011, 9:69 (21 October 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Toward a comprehensive language for biological systems James R Faeder BMC Biology 2011, 9:68 (17 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Biology is complex, and biologists are (mostly) resistant to modeling. James Faeder, lucidly challenging this resistance, welcomes a new rule-based software package reported in a recent paper in BMC Systems Biology that begins to confront the complexity.
		Commentary Host-parasite relationships in the genome John FY Brookfield BMC Biology 2011, 9:67 (10 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Commenting on a paper in BMC Evolutionary Biology, John Brookfield picks his way elegantly through the minefield of evolutionary issues bearing on the proliferation of transposons in the genomic ecosphere
		Question and Answer Q&A: What is the Golgi apparatus, and why are we asking? Sean Munro BMC Biology 2011, 9:63 (30 September 2011) Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.
		Research article Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B Amandine Duflocq, Fabrice Chareyre, Marco Giovannini, François Couraud, Marc Davenne BMC Biology 2011, 9:66 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Mobile DNA transposition in somatic cells Haig H Kazazian BMC Biology 2011, 9:62 (29 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Haig Kazazian discusses a growing body of evidence not only that DNA transposition events in somatic cells are common but that they may be biologically important.

	All
		Commentary Endothelio-hematopoietic relationship: getting closer to the beginnings Sabrina Gordon-Keylock, Alexander Medvinsky BMC Biology 2011, 9:88 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Both blood cells and vascular cells can differentiate from a single precursor cell, the hemangioblast. But what is the origin of the hemangioblast? Gordon-Keylock and Medvinsky discuss a new method of labeling these cells, reported by Ana T Tavares and colleagues, that may provide an answer.
		Research article Multiple origins of endosymbiosis within the Enterobacteriaceae (γ-Proteobacteria): convergence of complex phylogenetic approaches Filip Husník, Tomáš Chrudimský, Václav Hypša BMC Biology 2011, 9:87 (28 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Symbiosis is assumed to be a rare event, but a sophisticated evolutionary analysis picks apart the history of endosymbiosis between bacteria and insects and shows that in contrast to a single origin, symbiosis in this context has independently evolved a number of times.
		Correction The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA Philipp Kapranov, Georges St Laurent, Tal Raz, Fatih Ozsolak, C Patrick Reynolds, Poul HB Sorensen, Gregory Reaman, Patrice Milos, Robert J Arceci, John F Thompson, Timothy J Triche BMC Biology 2011, 9:86 (20 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Review Putting the pH into phosphatidic acid signaling John JH Shin, Christopher JR Loewen BMC Biology 2011, 9:85 (2 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary John Shin and Christopher Loewen explain how the unique properties of phosphatidic acid may equip it to act as a pH biosensor in the lipid membrane of cells, and review the emerging evidence that lipids monitor and respond to changes in cellular pH.
		Editorial Pit-bull reviewing, the pursuit of perfection and the victims of success Miranda Robertson BMC Biology 2011, 9:84 (1 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The festering discontent with reviewing and editorial practices in the high-profile biology journals has erupted into a new high-quality open access journal to be launched in 2012. Miranda Robertson explores the problem and the solutions offered, and revisits the re-review opt-out policy operated by BMC Biology.
		Research article Notch1 binds and induces degradation of Snail in hepatocellular carcinoma Seung-Oe Lim, Hyeon Kim, Xiaoyuan Quan, Sun-Min Ahn, Hongtae Kim, David Hsieh, Je Kyung Seong, Guhung Jung BMC Biology 2011, 9:83 (30 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth Lucas P Carlstrom, Jacob H Hines, Steven J Henle, John R Henley BMC Biology 2011, 9:82 (30 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Research article Motion dazzle and camouflage as distinct anti-predator defenses Martin Stevens, W Tom L Searle, Jenny E Seymour, Kate LA Marshall, Graeme D Ruxton BMC Biology 2011, 9:81 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements Morten Rye, Pål Sætrom, Tony Håndstad, Finn Drabløs BMC Biology 2011, 9:80 (24 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary How plants cope with temperature stress Virginia Walbot BMC Biology 2011, 9:79 (17 November 2011) Abstract \| Full text \| PDF \| PubMed
		Editorial Genes, animal models and the current understanding of psychiatric disease Penelope Austin BMC Biology 2011, 9:78 (11 November 2011) Full text \| PDF \| PubMed \| Editor’s summary Two articles in our Wiring the Brain series explore the implications of new genetic information on psychiatric disease for clinical practice and for elucidation of the complex biology of disorders of the mind. Penelope Austin explains the two points of view they reflect.
		Opinion Two patients walk into a clinic...a genomics perspective on the future of schizophrenia Aiden P Corvin BMC Biology 2011, 9:77 (11 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary How will progress in understanding genetic susceptibility to schizophrenia affect patients? Aiden Corvin suggests that it will not continue to be viewed as a single disease, and that diagnosis and treatment will be transformed.
		Review Following the genes: a framework for animal modeling of psychiatric disorders Kevin J Mitchell, Z Josh Huang, Bita Moghaddam, Akira Sawa BMC Biology 2011, 9:76 (11 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Following a brief overview of the revolution in psychiatric genetics, Kevin Mitchell and colleagues explain how the effects of causal mutations can be studied in animals to elucidate pathogenic mechanisms and neurobiological phenotypes of direct relevance to human disease.
		Research article Requirement for Pdx1 in specification of latent endocrine progenitors in zebrafish Robin A Kimmel, Lucas Onder, Armin Wilfinger, Elin Ellertsdottir, Dirk Meyer BMC Biology 2011, 9:75 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research article Sumo-dependent substrate targeting of the SUMO protease Ulp1 Zachary C Elmore, Megan Donaher, Brooke C Matson, Helen Murphy, Jason W Westerbeck, Oliver Kerscher BMC Biology 2011, 9:74 (28 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research article The docking protein p130Cas regulates cell sensitivity to proteasome inhibition Ming Zhao, Kristiina Vuori BMC Biology 2011, 9:73 (28 October 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas Dharminder Chauhan, Kenneth C Anderson BMC Biology 2011, 9:72 (28 October 2011) Abstract \| Full text \| PDF \| PubMed
		Review Molecular dynamics simulations and drug discovery Jacob D Durrant, J Andrew McCammon BMC Biology 2011, 9:71 (28 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Modeling the movements of atoms within macromolecules can predict their conformational flexibility to inform drug discovery. Jacob Durrant and Andrew McCammon explain how this is done in molecular dynamics simulations, reviewing both the successes and current limitations of the approach.
		Research article Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast Karin Lanthaler, Elizabeth Bilsland, Paul D Dobson, Harry J Moss, Pınar Pir, Douglas B Kell, Stephen G Oliver BMC Biology 2011, 9:70 (24 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors Alfredo Csibi, John Blenis BMC Biology 2011, 9:69 (21 October 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Toward a comprehensive language for biological systems James R Faeder BMC Biology 2011, 9:68 (17 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Biology is complex, and biologists are (mostly) resistant to modeling. James Faeder, lucidly challenging this resistance, welcomes a new rule-based software package reported in a recent paper in BMC Systems Biology that begins to confront the complexity.
		Commentary Host-parasite relationships in the genome John FY Brookfield BMC Biology 2011, 9:67 (10 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Commenting on a paper in BMC Evolutionary Biology, John Brookfield picks his way elegantly through the minefield of evolutionary issues bearing on the proliferation of transposons in the genomic ecosphere
		Question and Answer Q&A: What is the Golgi apparatus, and why are we asking? Sean Munro BMC Biology 2011, 9:63 (30 September 2011) Full text \| PDF \| PubMed \| 2 comments \| Editor’s summary Sean Munro explains in Q&A format why the Golgi apparatus remains a gently seething cauldron of controversy more than 120 years after its discovery.
		Research article Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B Amandine Duflocq, Fabrice Chareyre, Marco Giovannini, François Couraud, Marc Davenne BMC Biology 2011, 9:66 (29 September 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Mobile DNA transposition in somatic cells Haig H Kazazian BMC Biology 2011, 9:62 (29 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Haig Kazazian discusses a growing body of evidence not only that DNA transposition events in somatic cells are common but that they may be biologically important.