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		Research article TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production Shan Li, Stephen E Kendall, Raquel Raices, James Finlay, Maricela Covarrubias, Zheng Liu, Gina Lowe, Yu-Huey Lin, Yuan Teh, Victoria Leigh, Simi Dhillon, Steven Flanagan, Karen S Aboody, Carlotta A Glackin BMC Biology 2012, 10:73 (14 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research article A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability Asier Jayo, Maddy Parsons, Josephine C Adams BMC Biology 2012, 10:72 (10 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The actin-binding protein fascin is important for cell migration and its up-regulation is implicated in metastasis in several human carcinomas. Adams and colleagues visualize a direct interaction between fascin and LIM kinase 1/2, Rho-activated kinases, which regulate the stability of filopodia.
		Research article Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis Tobias H Klöpper, Nickias Kienle, Dirk Fasshauer, Sean Munro BMC Biology 2012, 10:71 (8 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The functional complexity made possible by the proteins that direct traffic between the internal membranes of eukaryotic cells lies at the heart of metazoan evolution. Sean Munro and colleagues trace the Rab family of membrane traffic proteins to its evolutionary roots.
		Commentary The Rabs: A family at the root of metazoan evolution Harald Stenmark BMC Biology 2012, 10:68 (8 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Harald Stenmark explains the interest in the phylogenetic analysis of Rab GTPases reported in a paper in BMC Biology, and sketches (literally) the diversity of membrane transport functions that correspond to the six functional groups proposed.
		Correction Rapid sympatric ecological differentiation of crater lake cichlid fishes within historic times Kathryn R Elmer, Topi K Lehtonen, Andreas F Kautt, Chris Harrod, Axel Meyer BMC Biology 2012, 10:70 (7 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model Bhupinder Virk, Gonçalo Correia, David P Dixon, Inna Feyst, Jie Jia, Nikolin Oberleitner, Zoe Briggs, Emily Hodge, Robert Edwards, John Ward, David Gems, David Weinkove BMC Biology 2012, 10:67 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary David Weinkove and colleagues report an accidental discovery in C. elegans that has led them to a series of studies implicating folate in excess of needs in limiting lifespan, with interesting hints from the effects of sulfonamide drugs that the same may apply to mammals.
		Commentary Folate status of gut microbiome affects Caenorhabditis elegans lifespan Theresa PT Nguyen, Catherine F Clarke BMC Biology 2012, 10:66 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on a recent report in BMC Biology on an adventitious discovery in nematode worms, Theresa Nguyen and Catherine Clarke speculate on the implications for human lifespan of folate supplementation and the effects of sulfonamide drugs on the microbiome.
		Research article Phylogenomic analyses support the position of turtles as the sister group of birds and crocodiles (Archosauria) Ylenia Chiari, Vincent Cahais, Nicolas Galtier, Frédéric Delsuc BMC Biology 2012, 10:65 (27 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Turtles have traditionally been hard to place taxonomically because of their unique morphology, and recent research based on microRNA has stirred the pot once again. Contrary to that work, phylogenomic analysis of a large new sequence data set adds strong support to the previous conclusion that turtles' closest evolutionary relatives are birds and crocodiles.
		Commentary Amniote phylogeny and the position of turtles S Blair Hedges BMC Biology 2012, 10:64 (27 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Commenting on research on the disputed evolutionary placement of turtles, Blair Hedges discusses how integration of data from different sources – DNA, morphology, and biogeography – can help to resolve evolutionary disputes.
		Research article Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism Jessica P Monserrate, Michelle Y-Y Chen, Carrie Brachmann BMC Biology 2012, 10:63 (24 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Induction of apoptotic cell death is not the only function of proteins of the Bcl-2 family. Carrie Brachmann and colleagues report that flies with mutations in the Drosophila Bcl-2 gene buffy have defective energy homeostasis - which has parallels in recent findings in mammalian hepatocyes and neurones.
		Research article Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx Sonja Wilke, Joern Krausze, Konrad Büssow BMC Biology 2012, 10:62 (19 July 2012) Abstract \| Full text \| PDF \| PubMed
		Opinion Shedding light on local kinase activation John D Scott, Alexandra C Newton BMC Biology 2012, 10:61 (17 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary John Scott and Alexandra Newton discuss the design of genetically encoded fluorescent biosensors that report on local kinase activation and second messenger action, and how they are revealing spatio-temporal patterns of intracellular signalling in living cells.
		Research article A universal scaling relationship between body mass and proximal limb bone dimensions in quadrupedal terrestrial tetrapods Nicolás E Campione, David C Evans BMC Biology 2012, 10:60 (10 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knowing the body mass of extinct taxa is an important prerequisite for making inferences about their physiology and ecology. Extrapolating from extant species, Campione and Evans present a straightforward equation based on bone dimensions that predicts body mass at least as well as more complex models.
		Opinion RNAi in the regulation of mammalian viral infections Kuan-Teh Jeang BMC Biology 2012, 10:58 (26 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gene silencing by RNA interference is an established antiviral defense in nematodes and fruit flies, but has been widely thought absent - and unnecessary - for mammalian defense against viruses. Kuan-Teh Jeang reviews emerging evidence that RNAi operates against viruses in mammals too.
		Research article Population dynamics and habitat sharing of natural populations of Caenorhabditis elegans and C. briggsae Marie-Anne Félix, Fabien Duveau BMC Biology 2012, 10:59 (25 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary It has been eloquently argued that you cannot understand a genome without knowing its natural history, and despite its being one of the key model species in biology, little is known about C. elegans in its natural environment. Felix and Duveau take a stride in the right direction with a report on the population dynamics of this nematode and the related C. briggsae in rotting apples in the orchards of France.
		Commentary The worm in the world and the world in the worm Mark Blaxter, Dee R Denver BMC Biology 2012, 10:57 (25 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary C. elegans is one of the iconic laboratory species, but how much do we know of its life in the wild? Very little, explain Mark Blaxter and Dee Denver, but new research in BMC Biology tells us more and provides a broader platform for research on this famous nematode and its cousins.
		Research article A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila Thomas Chertemps, Adrien François, Nicolas Durand, Gloria Rosell, Teun Dekker, Philippe Lucas, Martine Maïbèche-Coisne BMC Biology 2012, 10:56 (21 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A role for pheromone-degrading enzymes in modulating pheromone perception is now demonstrated in fruit flies, whose sensory perception of an anti-aphrodisiac, and behavioral responses to it, are enhanced in mutants that lack the enzyme capable of degrading this pheromone in vitro.
		Research article Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast João A Paredes, Laura Carreto, João Simões, Ana R Bezerra, Ana C Gomes, Rodrigo Santamaria, Misha Kapushesky, Gabriela R Moura, Manuel AS Santos BMC Biology 2012, 10:55 (20 June 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary Expanding networks of RNA virus evolution Eugene V Koonin, Valerian V Dolja BMC Biology 2012, 10:54 (20 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Eugene Koonin and Valerian Dolja consider the complex web of evolutionary relationships between RNA viruses, commenting on two new dsRNA genomes reported in BMC Evolutionary Biology, and two recent surprises yielded by metagenomics in geothermal waters.
		Commentary How a bird is an island Richard Lapoint, Noah Whiteman BMC Biology 2012, 10:53 (20 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adaptive radiations underlie much of the Earth's diversity. They usually occur on islands but, as Noah Whiteman and Richard Lapoint explain, in parasites hosts act as 'islands', separating populations and allowing adaptive radiations. Recent research in BMC Biology on feather lice could be the foundation for future work on this apparently rare evolutionary phenomenon.
		Research article Repeated adaptive divergence of microhabitat specialization in avian feather lice Kevin P Johnson, Scott M Shreve, Vincent S Smith BMC Biology 2012, 10:52 (20 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adaptive radiations, where a single species can quickly diversify to fill multiple niches in a new environment, are commonly seen in island systems. Kevin Johnson and colleagues show this pattern in feather lice, with different avian hosts acting as 'islands'.
		Research article Control of the olive fruit fly using genetics-enhanced sterile insect technique Thomas Ant, Martha Koukidou, Polychronis Rempoulakis, Hong-Fei Gong, Aris Economopoulos, John Vontas, Luke Alphey BMC Biology 2012, 10:51 (19 June 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary p97 complexes as signal integration hubs Hemmo Meyer BMC Biology 2012, 10:48 (13 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The AAA+ ATPase p97 is known to extract proteins from membranes or complexes for routing to the proteasome for degradation, but Hemmo Meyer, commenting on a recent article from Alexandru and colleagues in BMC Biology, draws attention to increasing evidence that it is a versatile hub for the formation of complexes with distinct functions in cell physiology.
		Correspondence No severe and global X chromosome inactivation in meiotic male germline of Drosophila Lyudmila M Mikhaylova, Dmitry I Nurminsky BMC Biology 2012, 10:50 (12 June 2012) Abstract \| Full text \| PDF \| PubMed
		Correspondence Re-analysis of the larval testis data on meiotic sex chromosome inactivation revealed evidence for tissue-specific gene expression related to the drosophila X chromosome Maria D Vibranovski, Yong E Zhang, Claus Kemkemer, Hedibert F Lopes, Timothy L Karr, Manyuan Long BMC Biology 2012, 10:49 (12 June 2012) Abstract \| Full text \| PDF \| PubMed

	All
		Research article TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production Shan Li, Stephen E Kendall, Raquel Raices, James Finlay, Maricela Covarrubias, Zheng Liu, Gina Lowe, Yu-Huey Lin, Yuan Teh, Victoria Leigh, Simi Dhillon, Steven Flanagan, Karen S Aboody, Carlotta A Glackin BMC Biology 2012, 10:73 (14 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research article A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability Asier Jayo, Maddy Parsons, Josephine C Adams BMC Biology 2012, 10:72 (10 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The actin-binding protein fascin is important for cell migration and its up-regulation is implicated in metastasis in several human carcinomas. Adams and colleagues visualize a direct interaction between fascin and LIM kinase 1/2, Rho-activated kinases, which regulate the stability of filopodia.
		Research article Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis Tobias H Klöpper, Nickias Kienle, Dirk Fasshauer, Sean Munro BMC Biology 2012, 10:71 (8 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The functional complexity made possible by the proteins that direct traffic between the internal membranes of eukaryotic cells lies at the heart of metazoan evolution. Sean Munro and colleagues trace the Rab family of membrane traffic proteins to its evolutionary roots.
		Commentary The Rabs: A family at the root of metazoan evolution Harald Stenmark BMC Biology 2012, 10:68 (8 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Harald Stenmark explains the interest in the phylogenetic analysis of Rab GTPases reported in a paper in BMC Biology, and sketches (literally) the diversity of membrane transport functions that correspond to the six functional groups proposed.
		Correction Rapid sympatric ecological differentiation of crater lake cichlid fishes within historic times Kathryn R Elmer, Topi K Lehtonen, Andreas F Kautt, Chris Harrod, Axel Meyer BMC Biology 2012, 10:70 (7 August 2012) Abstract \| Full text \| PDF \| PubMed
		Research article Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model Bhupinder Virk, Gonçalo Correia, David P Dixon, Inna Feyst, Jie Jia, Nikolin Oberleitner, Zoe Briggs, Emily Hodge, Robert Edwards, John Ward, David Gems, David Weinkove BMC Biology 2012, 10:67 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary David Weinkove and colleagues report an accidental discovery in C. elegans that has led them to a series of studies implicating folate in excess of needs in limiting lifespan, with interesting hints from the effects of sulfonamide drugs that the same may apply to mammals.
		Commentary Folate status of gut microbiome affects Caenorhabditis elegans lifespan Theresa PT Nguyen, Catherine F Clarke BMC Biology 2012, 10:66 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on a recent report in BMC Biology on an adventitious discovery in nematode worms, Theresa Nguyen and Catherine Clarke speculate on the implications for human lifespan of folate supplementation and the effects of sulfonamide drugs on the microbiome.
		Research article Phylogenomic analyses support the position of turtles as the sister group of birds and crocodiles (Archosauria) Ylenia Chiari, Vincent Cahais, Nicolas Galtier, Frédéric Delsuc BMC Biology 2012, 10:65 (27 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Turtles have traditionally been hard to place taxonomically because of their unique morphology, and recent research based on microRNA has stirred the pot once again. Contrary to that work, phylogenomic analysis of a large new sequence data set adds strong support to the previous conclusion that turtles' closest evolutionary relatives are birds and crocodiles.
		Commentary Amniote phylogeny and the position of turtles S Blair Hedges BMC Biology 2012, 10:64 (27 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Commenting on research on the disputed evolutionary placement of turtles, Blair Hedges discusses how integration of data from different sources – DNA, morphology, and biogeography – can help to resolve evolutionary disputes.
		Research article Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism Jessica P Monserrate, Michelle Y-Y Chen, Carrie Brachmann BMC Biology 2012, 10:63 (24 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Induction of apoptotic cell death is not the only function of proteins of the Bcl-2 family. Carrie Brachmann and colleagues report that flies with mutations in the Drosophila Bcl-2 gene buffy have defective energy homeostasis - which has parallels in recent findings in mammalian hepatocyes and neurones.
		Research article Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx Sonja Wilke, Joern Krausze, Konrad Büssow BMC Biology 2012, 10:62 (19 July 2012) Abstract \| Full text \| PDF \| PubMed
		Opinion Shedding light on local kinase activation John D Scott, Alexandra C Newton BMC Biology 2012, 10:61 (17 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary John Scott and Alexandra Newton discuss the design of genetically encoded fluorescent biosensors that report on local kinase activation and second messenger action, and how they are revealing spatio-temporal patterns of intracellular signalling in living cells.
		Research article A universal scaling relationship between body mass and proximal limb bone dimensions in quadrupedal terrestrial tetrapods Nicolás E Campione, David C Evans BMC Biology 2012, 10:60 (10 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Knowing the body mass of extinct taxa is an important prerequisite for making inferences about their physiology and ecology. Extrapolating from extant species, Campione and Evans present a straightforward equation based on bone dimensions that predicts body mass at least as well as more complex models.
		Opinion RNAi in the regulation of mammalian viral infections Kuan-Teh Jeang BMC Biology 2012, 10:58 (26 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gene silencing by RNA interference is an established antiviral defense in nematodes and fruit flies, but has been widely thought absent - and unnecessary - for mammalian defense against viruses. Kuan-Teh Jeang reviews emerging evidence that RNAi operates against viruses in mammals too.
		Research article Population dynamics and habitat sharing of natural populations of Caenorhabditis elegans and C. briggsae Marie-Anne Félix, Fabien Duveau BMC Biology 2012, 10:59 (25 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary It has been eloquently argued that you cannot understand a genome without knowing its natural history, and despite its being one of the key model species in biology, little is known about C. elegans in its natural environment. Felix and Duveau take a stride in the right direction with a report on the population dynamics of this nematode and the related C. briggsae in rotting apples in the orchards of France.
		Commentary The worm in the world and the world in the worm Mark Blaxter, Dee R Denver BMC Biology 2012, 10:57 (25 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary C. elegans is one of the iconic laboratory species, but how much do we know of its life in the wild? Very little, explain Mark Blaxter and Dee Denver, but new research in BMC Biology tells us more and provides a broader platform for research on this famous nematode and its cousins.
		Research article A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila Thomas Chertemps, Adrien François, Nicolas Durand, Gloria Rosell, Teun Dekker, Philippe Lucas, Martine Maïbèche-Coisne BMC Biology 2012, 10:56 (21 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A role for pheromone-degrading enzymes in modulating pheromone perception is now demonstrated in fruit flies, whose sensory perception of an anti-aphrodisiac, and behavioral responses to it, are enhanced in mutants that lack the enzyme capable of degrading this pheromone in vitro.
		Research article Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast João A Paredes, Laura Carreto, João Simões, Ana R Bezerra, Ana C Gomes, Rodrigo Santamaria, Misha Kapushesky, Gabriela R Moura, Manuel AS Santos BMC Biology 2012, 10:55 (20 June 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary Expanding networks of RNA virus evolution Eugene V Koonin, Valerian V Dolja BMC Biology 2012, 10:54 (20 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Eugene Koonin and Valerian Dolja consider the complex web of evolutionary relationships between RNA viruses, commenting on two new dsRNA genomes reported in BMC Evolutionary Biology, and two recent surprises yielded by metagenomics in geothermal waters.
		Commentary How a bird is an island Richard Lapoint, Noah Whiteman BMC Biology 2012, 10:53 (20 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adaptive radiations underlie much of the Earth's diversity. They usually occur on islands but, as Noah Whiteman and Richard Lapoint explain, in parasites hosts act as 'islands', separating populations and allowing adaptive radiations. Recent research in BMC Biology on feather lice could be the foundation for future work on this apparently rare evolutionary phenomenon.
		Research article Repeated adaptive divergence of microhabitat specialization in avian feather lice Kevin P Johnson, Scott M Shreve, Vincent S Smith BMC Biology 2012, 10:52 (20 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adaptive radiations, where a single species can quickly diversify to fill multiple niches in a new environment, are commonly seen in island systems. Kevin Johnson and colleagues show this pattern in feather lice, with different avian hosts acting as 'islands'.
		Research article Control of the olive fruit fly using genetics-enhanced sterile insect technique Thomas Ant, Martha Koukidou, Polychronis Rempoulakis, Hong-Fei Gong, Aris Economopoulos, John Vontas, Luke Alphey BMC Biology 2012, 10:51 (19 June 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary p97 complexes as signal integration hubs Hemmo Meyer BMC Biology 2012, 10:48 (13 June 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The AAA+ ATPase p97 is known to extract proteins from membranes or complexes for routing to the proteasome for degradation, but Hemmo Meyer, commenting on a recent article from Alexandru and colleagues in BMC Biology, draws attention to increasing evidence that it is a versatile hub for the formation of complexes with distinct functions in cell physiology.
		Correspondence No severe and global X chromosome inactivation in meiotic male germline of Drosophila Lyudmila M Mikhaylova, Dmitry I Nurminsky BMC Biology 2012, 10:50 (12 June 2012) Abstract \| Full text \| PDF \| PubMed
		Correspondence Re-analysis of the larval testis data on meiotic sex chromosome inactivation revealed evidence for tissue-specific gene expression related to the drosophila X chromosome Maria D Vibranovski, Yong E Zhang, Claus Kemkemer, Hedibert F Lopes, Timothy L Karr, Manyuan Long BMC Biology 2012, 10:49 (12 June 2012) Abstract \| Full text \| PDF \| PubMed