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		Question and Answer Q&A: Antibiotic resistance: what more do we know and what more can we do? Gerard D Wright BMC Biology 2013, 11:51 (17 May 2013) Full text \| PDF \| Editor’s summary Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.
		Research article On the origin of POU5F1 Stephen Frankenberg, Marilyn B Renfree BMC Biology 2013, 11:56 (9 May 2013) Abstract \| Provisional PDF \| PubMed
		Research article Spatial and temporal in vivo analysis of circulating and sessile immune cells in mosquitoes: hemocyte mitosis following infection Jonas G King, Julián F Hillyer BMC Biology 2013, 11:55 (30 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Observations on the number, location, phagocytic activity and cell division of hemocytes in the body cavity of mosquitoes sheds new light on the biology of insect immune system cells.
		Commentary Somatic and visceral nervous systems - an ancient duality Paola Bertucci, Detlev Arendt BMC Biology 2013, 11:54 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.
		Research article Ancient origin of somatic and visceral neurons Marc Nomaksteinsky, Stefan Kassabov, Zoubida Chettouh, Henri-Corto Stoeklé, Laure Bonnaud, Gilles Fortin, Eric R Kandel, Jean-François Brunet BMC Biology 2013, 11:53 (30 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The great American palaeontologist and anatomist Alfred Romer speculated that early in animal life, an emerging somatic nervous system, focused on the outside world, struggled to dominate the visceral nervous system that takes care of the internal systems that keep us alive. Jean-François Brunet and colleagues identify the molecular signatures that tell the evolutionary tale of this duality.
		Research article Statistical support for the hypothesis of developmental constraint in marsupial skull evolution C Verity Bennett, Anjali Goswami BMC Biology 2013, 11:52 (26 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article High-density linkage mapping in a pine tree reveals a genomic region associated with inbreeding depression and provides clues to the extent and distribution of meiotic recombination Emilie Chancerel, Jean-Baptiste Lamy, Isabelle Lesur, Céline Noirot, Christophe Klopp, François Ehrenmann, Christophe Boury, Grégoire Le Provost, Philippe Label, Céline Lalanne, Valérie Léger, Franck Salin, Jean-Marc Gion, Christophe Plomion BMC Biology 2013, 11:50 (18 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Radial glial cells play a key role in echinoderm neural regeneration Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás BMC Biology 2013, 11:49 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Repair of a cut radial nerve cord in a sea cucumber is mediated by radial glial cells that dedifferentiate, divide and give rise to new neurons.
		Anniversary Update Tropical rain forest evolution: palms as a model group Thomas LP Couvreur, William J Baker BMC Biology 2013, 11:48 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update White-nose syndrome in bats: illuminating the darkness Paul M Cryan, Carol Meteyer, Justin G Boyles, David S Blehert BMC Biology 2013, 11:47 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Seeing the Tree of Life behind the phylogenetic forest Pere Puigbò, Yuri I Wolf, Eugene V Koonin BMC Biology 2013, 11:46 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Arthropods and inherited bacteria: from counting the symbionts to understanding how symbionts count Olivier Duron, Gregory DD Hurst BMC Biology 2013, 11:45 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Segment assembly, structure alignment and iterative simulation in protein structure prediction Yang Zhang, Jeffrey Skolnick BMC Biology 2013, 11:44 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Systematic curation of protein and genetic interaction data for computable biology Kara Dolinski, Andrew Chatr-aryamontri, Mike Tyers BMC Biology 2013, 11:43 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Neurosensory transmission without a synapse: new perspectives on taste signaling Sue C Kinnamon BMC Biology 2013, 11:42 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Fuzzy species revisited William P Hanage BMC Biology 2013, 11:41 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update The new micro-kingdoms of eukaryotes Jan Pawlowski BMC Biology 2013, 11:40 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial Tenth anniversary updates from our authors Penelope Austin, Kester Jarvis BMC Biology 2013, 11:39 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Opinion Of flies and men: insights on organismal metabolism from fruit flies Akhila Rajan, Norbert Perrimon BMC Biology 2013, 11:38 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology, Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.
		Review Drugging Hedgehog: signaling the pathway to translation Tom J Carney, Philip W Ingham BMC Biology 2013, 11:37 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ten years ago Jeff Porter and colleagues published a screen for small-molecule modulators of the Hedgehog signaling pathway in the Journal of Biology. For BMC Biology’s 10^th anniversary, Tom Carney and Philip Ingham discuss the far-reaching clinical impact of some of the agonists and antagonists they discovered.
		Review LKB1 and AMPK and the cancer-metabolism link - ten years after D Hardie, Dario R Alessi BMC Biology 2013, 11:36 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ten years ago Grahame Hardie published in Journal of Biology (now BMC Biology) the discovery that the upstream activating kinase he was seeking for the multifarious energy sensor AMPK was the tumor suppressor, LKB1, that Dario Alessi was working on in a neighboring lab. For BMC Biology’s tenth anniversary they review some of what they have discovered since.
		Comment Domesticating the beast Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.
		Interview Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: An interview with Peter Walter Peter Walter, Miranda Robertson BMC Biology 2013, 11:34 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Interview An interview with Patrick O Brown on the origins and future of open access Patrick O Brown BMC Biology 2013, 11:33 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.
		Editorial A view forward from ten years of BMC Biology Miranda Robertson BMC Biology 2013, 11:32 (15 April 2013) Full text \| PDF
		Commentary Mitochondrial genomes as living ‘fossils’ Ian Small BMC Biology 2013, 11:30 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ian Small discusses why the "fossilised" mitochondrial genome of Liriodendron could have such a slow mutation rate, and what it might tell us about the evolution of RNA editing.
		Research article The “fossilized” mitochondrial genome of Liriodendron tulipifera: ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate Aaron O Richardson, Danny W Rice, Gregory J Young, Andrew J Alverson, Jeffrey D Palmer BMC Biology 2013, 11:29 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mitochondrial genome of the tulip tree has a remarkably slow rate of nucleotide substitution, and could offer insight into the content and organisation of this genome in the ancestral flowering plant.
		Commentary Biological functions of natural antisense transcripts Andreas Werner BMC Biology 2013, 11:31 (12 April 2013) Abstract \| Full text \| PDF \| PubMed
		Question and Answer Q&A: Who needs a centrosome? Mónica Bettencourt-Dias BMC Biology 2013, 11:28 (11 April 2013) Full text \| PDF \| PubMed \| Editor’s summary The centrosome is classically regarded as the microtubule-organizing center of the cell. But cells can divide without them, and exactly what they do is largely mysterious. In a Q&A article in a series on cell geometry, Monica Bettencourt-Dias asks what we do know and what we don’t, about normal centrosomes and the abnormalities underlying disease.
		Research article The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling Roman H Khonsari, Maisa Seppala, Alan Pradel, Hugo Dutel, Gaël Clément, Oleg Lebedev, Sarah Ghafoor, Michaela Rothova, Abigael Tucker, John G Maisey, Chen-Ming Fan, Maiko Kawasaki, Atsushi Ohazama, Paul Tafforeau, Brunella Franco, Jill Helms, Courtney J Haycraft, Albert David, Philippe Janvier, Martyn T Cobourne, Paul T Sharpe BMC Biology 2013, 11:27 (28 March 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: Reflections on plant development and genetics Virginia Walbot BMC Biology 2013, 11:25 (28 March 2013) Full text \| PDF \| PubMed \| Editor’s summary For the BMC Biology 10^th anniversary series of open questions, Virginia Walbot reflects on how genomics has contributed to our understanding of plants over the last ten years, and the challenge of understanding how the flexible phenotypes of plants may adapt to environmental effects in future.
		Research article Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio) Alexander G Little, Tatsuya Kunisue, Kurunthachalam Kannan, Frank Seebacher BMC Biology 2013, 11:26 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Thyroid hormone plays an important part in adaptation to changing ambient temperature conditions in mammals, but surprisingly, its role in such adaptation in ectotherms is not known. Alexander Little and colleagues report investigations on zebrafish that suggest it is important for cold-blooded vertebrate adaptation too.
		Research article Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae Michaela de Clare, Stephen G Oliver BMC Biology 2013, 11:24 (25 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the effect of copy number variation on growth, apoptosis and the cell cycle for a selected subset of Saccharomyces cerevisiae genes suggests that using this model yeast to predict the effects of similar copy number variants in human cancers is a worthwhile approach.
		Research article Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss Tao Zhu, Deng-Ke Niu BMC Biology 2013, 11:23 (5 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary It is well established that intron loss is common in gene evolution, but three competing theories have been proposed to explain it. A new study supports the model involving reverse transcription, by analysing genomic byproducts of reverse transcriptase activity.
		Research article Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration Su-Ren Chen, Qiao-Song Zheng, Yang Zhang, Fei Gao, Yi-Xun Liu BMC Biology 2013, 11:22 (5 March 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: Epigenetics and the role of heterochromatin in development Susan M Gasser BMC Biology 2013, 11:21 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary As part of BMC Biology’s 10^th anniversary collection, Susan Gasser’s open questions link heterochromatin-mediated silencing, nuclear localisation and the true nature of epigenetic control.
		Research article Molecular basis for prey relocation in viperid snakes Anthony J Saviola, David Chiszar, Chardelle Busch, Stephen P Mackessy BMC Biology 2013, 11:20 (1 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Viperid snakes bite their prey and then let them go to avoid retaliation. By measuring snake behavior and analysing venom chemistry, Stephen Mackessy and colleagues provide an answer to how they find them again.
		Research article A functional genomics screen for microRNA regulators of NF-kappaB signaling Anthony O Olarerin-George, Lauren Anton, Yih-Chii Hwang, Michal A Elovitz, John B Hogenesch BMC Biology 2013, 11:19 (28 February 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial Q&A: Re-review opt-out and painless publishing Miranda Robertson BMC Biology 2013, 11:18 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary BMC Biology operates on the principle that the function of a journal is to facilitate publication of sound research results. Miranda Robertson reviews in Q&A format the journal’s re-review opt-out policy and how it has worked over the four years of its operation.
		Comment Open questions: What is there left for cell biologists to do? Sean Munro BMC Biology 2013, 11:16 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In a contribution to the 10^th anniversary series on open questions in biology, Sean Munro asks provocatively what there is left for cell biologists to do, and with great elan and a touch of waspish humor produces five unanswered questions on issues from the special properties of non-dividing cells to the architecture of the brain.
		Research article Genome mining for methanobactins Grace E Kenney, Amy C Rosenzweig BMC Biology 2013, 11:17 (26 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Methanotrophic bacteria have potential as a biological methane sink, and methanobactins are a set of peptides important in regulating this activity. A genome mining study highlights genes involved in methanobactin production, but also suggests that not all methanotrophs have them.
		Research article Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts José Viñuelas, Gaël Kaneko, Antoine Coulon, Elodie Vallin, Valérie Morin, Camila Mejia-Pous, Jean-Jacques Kupiec, Guillaume Beslon, Olivier Gandrillon BMC Biology 2013, 11:15 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A combined biological and computational approach adds further detail to a growing body of evidence that most genes undergo short bursts of transcription interspersed between long periods of downtime.
		Commentary Predicting the evolution of antibiotic resistance Martijn F Schenk, J Arjan GM de Visser BMC Biology 2013, 11:14 (22 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on research in BMC Evolutionary Biology, Arjan de Visser and Martijn Schenk discuss how two genetic properties, pleiotropy and epistasis, might help us to predict the evolution of antibiotic resistance.
		Research article Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles Jingxia Xu, Thomas Gridley BMC Biology 2013, 11:13 (13 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article MST1, a key player, in enhancing fast skeletal muscle atrophy Bin Wei, Wen Dui, Dong Liu, Yan Xing, Zengqiang Yuan, Guangju Ji BMC Biology 2013, 11:12 (1 February 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: Chromosome condensation - Why does a chromosome look like a chromosome? Frank Uhlmann BMC Biology 2013, 11:9 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In his contribution to the ‘Open questions’ anniversary collection for BMC Biology, Frank Uhlmann poses the unsolved problem of chromosome packaging
		Comment Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms Stephen J Benkovic, Julie Theriot, Dagmar Ringe BMC Biology 2013, 11:8 (31 January 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial Open questions in biology - a tenth anniversary series Miranda Robertson BMC Biology 2013, 11:7 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To celebrate its tenth anniversary, BMC Biology asked its Editorial Board members to write a paragraph or two on their favorite open questions in biology, and this month it publishes the first contributions, on topics from the challenges of proteomics to the mechanisms of apoptosis.
		Methodology article Multi-channel acoustic recording and automated analysis of Drosophila courtship songs Benjamin J Arthur, Tomoko Sunayama-Morita, Philip Coen, Mala Murthy, David L Stern BMC Biology 2013, 11:11 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Drosophila fruit flies' "singing" during courtship is a model system for both genetic and neural control of behaviour. A newly-designed recording system allows for analysis of the songs' various rhythms and cycles in unprecedented detail.
		Comment Open questions: missing pieces from the immunological jigsaw puzzle Gillian M Griffiths BMC Biology 2013, 11:10 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gillian Griffiths, in her ‘Open questions’ contribution for BMC Biology, pinpoints some critical missing links in the cell-biological specializations of immune cells

	All
		Question and Answer Q&A: Antibiotic resistance: what more do we know and what more can we do? Gerard D Wright BMC Biology 2013, 11:51 (17 May 2013) Full text \| PDF \| Editor’s summary Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.
		Research article On the origin of POU5F1 Stephen Frankenberg, Marilyn B Renfree BMC Biology 2013, 11:56 (9 May 2013) Abstract \| Provisional PDF \| PubMed
		Research article Spatial and temporal in vivo analysis of circulating and sessile immune cells in mosquitoes: hemocyte mitosis following infection Jonas G King, Julián F Hillyer BMC Biology 2013, 11:55 (30 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Observations on the number, location, phagocytic activity and cell division of hemocytes in the body cavity of mosquitoes sheds new light on the biology of insect immune system cells.
		Commentary Somatic and visceral nervous systems - an ancient duality Paola Bertucci, Detlev Arendt BMC Biology 2013, 11:54 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.
		Research article Ancient origin of somatic and visceral neurons Marc Nomaksteinsky, Stefan Kassabov, Zoubida Chettouh, Henri-Corto Stoeklé, Laure Bonnaud, Gilles Fortin, Eric R Kandel, Jean-François Brunet BMC Biology 2013, 11:53 (30 April 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The great American palaeontologist and anatomist Alfred Romer speculated that early in animal life, an emerging somatic nervous system, focused on the outside world, struggled to dominate the visceral nervous system that takes care of the internal systems that keep us alive. Jean-François Brunet and colleagues identify the molecular signatures that tell the evolutionary tale of this duality.
		Research article Statistical support for the hypothesis of developmental constraint in marsupial skull evolution C Verity Bennett, Anjali Goswami BMC Biology 2013, 11:52 (26 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article High-density linkage mapping in a pine tree reveals a genomic region associated with inbreeding depression and provides clues to the extent and distribution of meiotic recombination Emilie Chancerel, Jean-Baptiste Lamy, Isabelle Lesur, Céline Noirot, Christophe Klopp, François Ehrenmann, Christophe Boury, Grégoire Le Provost, Philippe Label, Céline Lalanne, Valérie Léger, Franck Salin, Jean-Marc Gion, Christophe Plomion BMC Biology 2013, 11:50 (18 April 2013) Abstract \| Provisional PDF \| PubMed
		Research article Radial glial cells play a key role in echinoderm neural regeneration Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás BMC Biology 2013, 11:49 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Repair of a cut radial nerve cord in a sea cucumber is mediated by radial glial cells that dedifferentiate, divide and give rise to new neurons.
		Anniversary Update Tropical rain forest evolution: palms as a model group Thomas LP Couvreur, William J Baker BMC Biology 2013, 11:48 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update White-nose syndrome in bats: illuminating the darkness Paul M Cryan, Carol Meteyer, Justin G Boyles, David S Blehert BMC Biology 2013, 11:47 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Seeing the Tree of Life behind the phylogenetic forest Pere Puigbò, Yuri I Wolf, Eugene V Koonin BMC Biology 2013, 11:46 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Arthropods and inherited bacteria: from counting the symbionts to understanding how symbionts count Olivier Duron, Gregory DD Hurst BMC Biology 2013, 11:45 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Segment assembly, structure alignment and iterative simulation in protein structure prediction Yang Zhang, Jeffrey Skolnick BMC Biology 2013, 11:44 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Systematic curation of protein and genetic interaction data for computable biology Kara Dolinski, Andrew Chatr-aryamontri, Mike Tyers BMC Biology 2013, 11:43 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Neurosensory transmission without a synapse: new perspectives on taste signaling Sue C Kinnamon BMC Biology 2013, 11:42 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update Fuzzy species revisited William P Hanage BMC Biology 2013, 11:41 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Anniversary Update The new micro-kingdoms of eukaryotes Jan Pawlowski BMC Biology 2013, 11:40 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Editorial Tenth anniversary updates from our authors Penelope Austin, Kester Jarvis BMC Biology 2013, 11:39 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Opinion Of flies and men: insights on organismal metabolism from fruit flies Akhila Rajan, Norbert Perrimon BMC Biology 2013, 11:38 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology, Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.
		Review Drugging Hedgehog: signaling the pathway to translation Tom J Carney, Philip W Ingham BMC Biology 2013, 11:37 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ten years ago Jeff Porter and colleagues published a screen for small-molecule modulators of the Hedgehog signaling pathway in the Journal of Biology. For BMC Biology’s 10^th anniversary, Tom Carney and Philip Ingham discuss the far-reaching clinical impact of some of the agonists and antagonists they discovered.
		Review LKB1 and AMPK and the cancer-metabolism link - ten years after D Hardie, Dario R Alessi BMC Biology 2013, 11:36 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ten years ago Grahame Hardie published in Journal of Biology (now BMC Biology) the discovery that the upstream activating kinase he was seeking for the multifarious energy sensor AMPK was the tumor suppressor, LKB1, that Dario Alessi was working on in a neighboring lab. For BMC Biology’s tenth anniversary they review some of what they have discovered since.
		Comment Domesticating the beast Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.
		Interview Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: An interview with Peter Walter Peter Walter, Miranda Robertson BMC Biology 2013, 11:34 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central
		Interview An interview with Patrick O Brown on the origins and future of open access Patrick O Brown BMC Biology 2013, 11:33 (15 April 2013) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.
		Editorial A view forward from ten years of BMC Biology Miranda Robertson BMC Biology 2013, 11:32 (15 April 2013) Full text \| PDF
		Commentary Mitochondrial genomes as living ‘fossils’ Ian Small BMC Biology 2013, 11:30 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ian Small discusses why the "fossilised" mitochondrial genome of Liriodendron could have such a slow mutation rate, and what it might tell us about the evolution of RNA editing.
		Research article The “fossilized” mitochondrial genome of Liriodendron tulipifera: ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate Aaron O Richardson, Danny W Rice, Gregory J Young, Andrew J Alverson, Jeffrey D Palmer BMC Biology 2013, 11:29 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The mitochondrial genome of the tulip tree has a remarkably slow rate of nucleotide substitution, and could offer insight into the content and organisation of this genome in the ancestral flowering plant.
		Commentary Biological functions of natural antisense transcripts Andreas Werner BMC Biology 2013, 11:31 (12 April 2013) Abstract \| Full text \| PDF \| PubMed
		Question and Answer Q&A: Who needs a centrosome? Mónica Bettencourt-Dias BMC Biology 2013, 11:28 (11 April 2013) Full text \| PDF \| PubMed \| Editor’s summary The centrosome is classically regarded as the microtubule-organizing center of the cell. But cells can divide without them, and exactly what they do is largely mysterious. In a Q&A article in a series on cell geometry, Monica Bettencourt-Dias asks what we do know and what we don’t, about normal centrosomes and the abnormalities underlying disease.
		Research article The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling Roman H Khonsari, Maisa Seppala, Alan Pradel, Hugo Dutel, Gaël Clément, Oleg Lebedev, Sarah Ghafoor, Michaela Rothova, Abigael Tucker, John G Maisey, Chen-Ming Fan, Maiko Kawasaki, Atsushi Ohazama, Paul Tafforeau, Brunella Franco, Jill Helms, Courtney J Haycraft, Albert David, Philippe Janvier, Martyn T Cobourne, Paul T Sharpe BMC Biology 2013, 11:27 (28 March 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: Reflections on plant development and genetics Virginia Walbot BMC Biology 2013, 11:25 (28 March 2013) Full text \| PDF \| PubMed \| Editor’s summary For the BMC Biology 10^th anniversary series of open questions, Virginia Walbot reflects on how genomics has contributed to our understanding of plants over the last ten years, and the challenge of understanding how the flexible phenotypes of plants may adapt to environmental effects in future.
		Research article Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio) Alexander G Little, Tatsuya Kunisue, Kurunthachalam Kannan, Frank Seebacher BMC Biology 2013, 11:26 (26 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Thyroid hormone plays an important part in adaptation to changing ambient temperature conditions in mammals, but surprisingly, its role in such adaptation in ectotherms is not known. Alexander Little and colleagues report investigations on zebrafish that suggest it is important for cold-blooded vertebrate adaptation too.
		Research article Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae Michaela de Clare, Stephen G Oliver BMC Biology 2013, 11:24 (25 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the effect of copy number variation on growth, apoptosis and the cell cycle for a selected subset of Saccharomyces cerevisiae genes suggests that using this model yeast to predict the effects of similar copy number variants in human cancers is a worthwhile approach.
		Research article Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss Tao Zhu, Deng-Ke Niu BMC Biology 2013, 11:23 (5 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary It is well established that intron loss is common in gene evolution, but three competing theories have been proposed to explain it. A new study supports the model involving reverse transcription, by analysing genomic byproducts of reverse transcriptase activity.
		Research article Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration Su-Ren Chen, Qiao-Song Zheng, Yang Zhang, Fei Gao, Yi-Xun Liu BMC Biology 2013, 11:22 (5 March 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: Epigenetics and the role of heterochromatin in development Susan M Gasser BMC Biology 2013, 11:21 (4 March 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary As part of BMC Biology’s 10^th anniversary collection, Susan Gasser’s open questions link heterochromatin-mediated silencing, nuclear localisation and the true nature of epigenetic control.
		Research article Molecular basis for prey relocation in viperid snakes Anthony J Saviola, David Chiszar, Chardelle Busch, Stephen P Mackessy BMC Biology 2013, 11:20 (1 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Viperid snakes bite their prey and then let them go to avoid retaliation. By measuring snake behavior and analysing venom chemistry, Stephen Mackessy and colleagues provide an answer to how they find them again.
		Research article A functional genomics screen for microRNA regulators of NF-kappaB signaling Anthony O Olarerin-George, Lauren Anton, Yih-Chii Hwang, Michal A Elovitz, John B Hogenesch BMC Biology 2013, 11:19 (28 February 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial Q&A: Re-review opt-out and painless publishing Miranda Robertson BMC Biology 2013, 11:18 (28 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary BMC Biology operates on the principle that the function of a journal is to facilitate publication of sound research results. Miranda Robertson reviews in Q&A format the journal’s re-review opt-out policy and how it has worked over the four years of its operation.
		Comment Open questions: What is there left for cell biologists to do? Sean Munro BMC Biology 2013, 11:16 (27 February 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In a contribution to the 10^th anniversary series on open questions in biology, Sean Munro asks provocatively what there is left for cell biologists to do, and with great elan and a touch of waspish humor produces five unanswered questions on issues from the special properties of non-dividing cells to the architecture of the brain.
		Research article Genome mining for methanobactins Grace E Kenney, Amy C Rosenzweig BMC Biology 2013, 11:17 (26 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Methanotrophic bacteria have potential as a biological methane sink, and methanobactins are a set of peptides important in regulating this activity. A genome mining study highlights genes involved in methanobactin production, but also suggests that not all methanotrophs have them.
		Research article Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts José Viñuelas, Gaël Kaneko, Antoine Coulon, Elodie Vallin, Valérie Morin, Camila Mejia-Pous, Jean-Jacques Kupiec, Guillaume Beslon, Olivier Gandrillon BMC Biology 2013, 11:15 (25 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A combined biological and computational approach adds further detail to a growing body of evidence that most genes undergo short bursts of transcription interspersed between long periods of downtime.
		Commentary Predicting the evolution of antibiotic resistance Martijn F Schenk, J Arjan GM de Visser BMC Biology 2013, 11:14 (22 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Commenting on research in BMC Evolutionary Biology, Arjan de Visser and Martijn Schenk discuss how two genetic properties, pleiotropy and epistasis, might help us to predict the evolution of antibiotic resistance.
		Research article Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles Jingxia Xu, Thomas Gridley BMC Biology 2013, 11:13 (13 February 2013) Abstract \| Full text \| PDF \| PubMed
		Research article MST1, a key player, in enhancing fast skeletal muscle atrophy Bin Wei, Wen Dui, Dong Liu, Yan Xing, Zengqiang Yuan, Guangju Ji BMC Biology 2013, 11:12 (1 February 2013) Abstract \| Full text \| PDF \| PubMed
		Comment Open questions: Chromosome condensation - Why does a chromosome look like a chromosome? Frank Uhlmann BMC Biology 2013, 11:9 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In his contribution to the ‘Open questions’ anniversary collection for BMC Biology, Frank Uhlmann poses the unsolved problem of chromosome packaging
		Comment Open questions - in brief: Beyond -omics, missing motor proteins, and getting from molecules to organisms Stephen J Benkovic, Julie Theriot, Dagmar Ringe BMC Biology 2013, 11:8 (31 January 2013) Abstract \| Full text \| PDF \| PubMed
		Editorial Open questions in biology - a tenth anniversary series Miranda Robertson BMC Biology 2013, 11:7 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To celebrate its tenth anniversary, BMC Biology asked its Editorial Board members to write a paragraph or two on their favorite open questions in biology, and this month it publishes the first contributions, on topics from the challenges of proteomics to the mechanisms of apoptosis.
		Methodology article Multi-channel acoustic recording and automated analysis of Drosophila courtship songs Benjamin J Arthur, Tomoko Sunayama-Morita, Philip Coen, Mala Murthy, David L Stern BMC Biology 2013, 11:11 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Drosophila fruit flies' "singing" during courtship is a model system for both genetic and neural control of behaviour. A newly-designed recording system allows for analysis of the songs' various rhythms and cycles in unprecedented detail.
		Comment Open questions: missing pieces from the immunological jigsaw puzzle Gillian M Griffiths BMC Biology 2013, 11:10 (31 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gillian Griffiths, in her ‘Open questions’ contribution for BMC Biology, pinpoints some critical missing links in the cell-biological specializations of immune cells