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Thirty years on: HIV receptor gymnastics and the prevention of infection
Robin A Weiss BMC Biology 2013, 11:57 (21 May 2013)
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Robin Weiss, in an article to mark the 30th anniversary of the discovery of the human immunodeficiency virus (HIV), reviews the complex interactions of the virus with the specialized surface molecules by which it gains entry into cells, and how this has led to drugs that block it.
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Q&A: Antibiotic resistance: what more do we know and what more can we do?
Gerard D Wright BMC Biology 2013, 11:51 (17 May 2013)
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Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.
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On the origin of POU5F1
Stephen Frankenberg, Marilyn B Renfree BMC Biology 2013, 11:56 (9 May 2013)
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Somatic and visceral nervous systems - an ancient duality
Paola Bertucci, Detlev Arendt BMC Biology 2013, 11:54 (30 April 2013)
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The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.
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Radial glial cells play a key role in echinoderm neural regeneration
Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás BMC Biology 2013, 11:49 (18 April 2013)
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Repair of a cut radial nerve cord in a sea cucumber is mediated by radial glial cells that dedifferentiate, divide and give rise to new neurons.
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Tropical rain forest evolution: palms as a model group
Thomas LP Couvreur, William J Baker BMC Biology 2013, 11:48 (15 April 2013)
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White-nose syndrome in bats: illuminating the darkness
Paul M Cryan, Carol Meteyer, Justin G Boyles, David S Blehert BMC Biology 2013, 11:47 (15 April 2013)
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Seeing the Tree of Life behind the phylogenetic forest
Pere Puigbò, Yuri I Wolf, Eugene V Koonin BMC Biology 2013, 11:46 (15 April 2013)
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Arthropods and inherited bacteria: from counting the symbionts to understanding how symbionts count
Olivier Duron, Gregory DD Hurst BMC Biology 2013, 11:45 (15 April 2013)
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Segment assembly, structure alignment and iterative simulation in protein structure prediction
Yang Zhang, Jeffrey Skolnick BMC Biology 2013, 11:44 (15 April 2013)
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Systematic curation of protein and genetic interaction data for computable biology
Kara Dolinski, Andrew Chatr-aryamontri, Mike Tyers BMC Biology 2013, 11:43 (15 April 2013)
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Neurosensory transmission without a synapse: new perspectives on taste signaling
Sue C Kinnamon BMC Biology 2013, 11:42 (15 April 2013)
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Fuzzy species revisited
William P Hanage BMC Biology 2013, 11:41 (15 April 2013)
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The new micro-kingdoms of eukaryotes
Jan Pawlowski BMC Biology 2013, 11:40 (15 April 2013)
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Tenth anniversary updates from our authors
Penelope Austin, Kester Jarvis BMC Biology 2013, 11:39 (15 April 2013)
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Of flies and men: insights on organismal metabolism from fruit flies
Akhila Rajan, Norbert Perrimon BMC Biology 2013, 11:38 (15 April 2013)
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For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology, Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.
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Drugging Hedgehog: signaling the pathway to translation
Tom J Carney, Philip W Ingham BMC Biology 2013, 11:37 (15 April 2013)
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Ten years ago Jeff Porter and colleagues published a screen for small-molecule modulators of the Hedgehog signaling pathway in the Journal of Biology. For BMC Biology’s 10th anniversary, Tom Carney and Philip Ingham discuss the far-reaching clinical impact of some of the agonists and antagonists they discovered.
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LKB1 and AMPK and the cancer-metabolism link - ten years after
D Hardie, Dario R Alessi BMC Biology 2013, 11:36 (15 April 2013)
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Ten years ago Grahame Hardie published in Journal of Biology (now BMC Biology) the discovery that the upstream activating kinase he was seeking for the multifarious energy sensor AMPK was the tumor suppressor, LKB1, that Dario Alessi was working on in a neighboring lab. For BMC Biology’s tenth anniversary they review some of what they have discovered since.
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Domesticating the beast
Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013)
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In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.
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Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: An interview with Peter Walter
Peter Walter, Miranda Robertson BMC Biology 2013, 11:34 (15 April 2013)
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An interview with Patrick O Brown on the origins and future of open access
Patrick O Brown BMC Biology 2013, 11:33 (15 April 2013)
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In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.
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A view forward from ten years of BMC Biology
Miranda Robertson BMC Biology 2013, 11:32 (15 April 2013)
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Mitochondrial genomes as living ‘fossils’
Ian Small BMC Biology 2013, 11:30 (15 April 2013)
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Ian Small discusses why the "fossilised" mitochondrial genome of Liriodendron could have such a slow mutation rate, and what it might tell us about the evolution of RNA editing.
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The “fossilized” mitochondrial genome of Liriodendron tulipifera: ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate
Aaron O Richardson, Danny W Rice, Gregory J Young, Andrew J Alverson, Jeffrey D Palmer BMC Biology 2013, 11:29 (15 April 2013)
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The mitochondrial genome of the tulip tree has a remarkably slow rate of nucleotide substitution, and could offer insight into the content and organisation of this genome in the ancestral flowering plant.
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Biological functions of natural antisense transcripts
Andreas Werner BMC Biology 2013, 11:31 (12 April 2013)
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