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Opinion   Open Access

Thirty years on: HIV receptor gymnastics and the prevention of infection

Robin A Weiss BMC Biology 2013, 11:57 (21 May 2013)

Abstract | Full text | PDF |  Editor’s summary

Robin Weiss, in an article to mark the 30th anniversary of the discovery of the human immunodeficiency virus (HIV), reviews the complex interactions of the virus with the specialized surface molecules by which it gains entry into cells, and how this has led to drugs that block it.

Question and Answer   Open Access

Q&A: Antibiotic resistance: what more do we know and what more can we do?

Gerard D Wright BMC Biology 2013, 11:51 (17 May 2013)

Full text | PDF |  Editor’s summary

Antibiotic resistance is both an ancient phenomenon and a worsening medical problem. Gerard Wright explains why, and what should be done about it.

Research article   Open Access

On the origin of POU5F1

Stephen Frankenberg, Marilyn B Renfree BMC Biology 2013, 11:56 (9 May 2013)

Abstract | Provisional PDF | PubMed

Commentary   Open Access Highly Accessed

Somatic and visceral nervous systems - an ancient duality

Paola Bertucci, Detlev Arendt BMC Biology 2013, 11:54 (30 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The idea that vertebrates are composed of a ‘visceral’ and ‘somatic’ self, responding to internal and external stimuli, respectively, was first put forward in the 19th century. Now, molecular fingerprinting indicates a duality between the somatic and visceral nervous systems that appears to predate Bilataria.

Research article   Open Access

Radial glial cells play a key role in echinoderm neural regeneration

Vladimir S Mashanov, Olga R Zueva, José E García-Arrarás BMC Biology 2013, 11:49 (18 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Repair of a cut radial nerve cord in a sea cucumber is mediated by radial glial cells that dedifferentiate, divide and give rise to new neurons.

Anniversary Update   Open Access

Tropical rain forest evolution: palms as a model group

Thomas LP Couvreur, William J Baker BMC Biology 2013, 11:48 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

White-nose syndrome in bats: illuminating the darkness

Paul M Cryan, Carol Meteyer, Justin G Boyles, David S Blehert BMC Biology 2013, 11:47 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Seeing the Tree of Life behind the phylogenetic forest

Pere Puigbò, Yuri I Wolf, Eugene V Koonin BMC Biology 2013, 11:46 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Arthropods and inherited bacteria: from counting the symbionts to understanding how symbionts count

Olivier Duron, Gregory DD Hurst BMC Biology 2013, 11:45 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Segment assembly, structure alignment and iterative simulation in protein structure prediction

Yang Zhang, Jeffrey Skolnick BMC Biology 2013, 11:44 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Systematic curation of protein and genetic interaction data for computable biology

Kara Dolinski, Andrew Chatr-aryamontri, Mike Tyers BMC Biology 2013, 11:43 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Neurosensory transmission without a synapse: new perspectives on taste signaling

Sue C Kinnamon BMC Biology 2013, 11:42 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

Fuzzy species revisited

William P Hanage BMC Biology 2013, 11:41 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Anniversary Update   Open Access

The new micro-kingdoms of eukaryotes

Jan Pawlowski BMC Biology 2013, 11:40 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Editorial   Open Access

Tenth anniversary updates from our authors

Penelope Austin, Kester Jarvis BMC Biology 2013, 11:39 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Opinion   Open Access

Of flies and men: insights on organismal metabolism from fruit flies

Akhila Rajan, Norbert Perrimon BMC Biology 2013, 11:38 (15 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

For many reasons metabolism is now a high-profile topic, and in an update to mark the tenth anniversary of BMC Biology, Norbert Perrimon and Akhila Rajan review the remarkable similarities that make Drosophila a model for mammalian metabolism, and some recent advances made possible by the advantages of this model organism.

Review   Open Access

Drugging Hedgehog: signaling the pathway to translation

Tom J Carney, Philip W Ingham BMC Biology 2013, 11:37 (15 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Ten years ago Jeff Porter and colleagues published a screen for small-molecule modulators of the Hedgehog signaling pathway in the Journal of Biology. For BMC Biology’s 10th anniversary, Tom Carney and Philip Ingham discuss the far-reaching clinical impact of some of the agonists and antagonists they discovered.

Review   Open Access Highly Accessed

LKB1 and AMPK and the cancer-metabolism link - ten years after

D Hardie, Dario R Alessi BMC Biology 2013, 11:36 (15 April 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Ten years ago Grahame Hardie published in Journal of Biology (now BMC Biology) the discovery that the upstream activating kinase he was seeking for the multifarious energy sensor AMPK was the tumor suppressor, LKB1, that Dario Alessi was working on in a neighboring lab. For BMC Biology’s tenth anniversary they review some of what they have discovered since.

Comment   Open Access Highly Accessed

Domesticating the beast

Virginia Walbot BMC Biology 2013, 11:35 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In 2009, Virginia Walbot commented ‘Are we training pit bulls to review our manuscripts?’ Revisiting the topic, she asks if we can tame our pit bull reviewers by involving students more in peer review and teaching them to see things from an authors’ perspective and the perspective of the journal that is responsible for making a decision on publication.

Interview   Open Access

Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: An interview with Peter Walter

Peter Walter, Miranda Robertson BMC Biology 2013, 11:34 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central

Interview   Open Access Highly Accessed

An interview with Patrick O Brown on the origins and future of open access

Patrick O Brown BMC Biology 2013, 11:33 (15 April 2013)

Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

In an interview for the BMC Biology tenth anniversary collection, Patrick O Brown excavates his memory for the origins of open access publishing, and finds a vision of the future still to be fulfilled.

Editorial   Open Access

A view forward from ten years of BMC Biology

Miranda Robertson BMC Biology 2013, 11:32 (15 April 2013)

Full text | PDF

Commentary   Open Access Highly Accessed

Mitochondrial genomes as living ‘fossils’

Ian Small BMC Biology 2013, 11:30 (15 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Ian Small discusses why the "fossilised" mitochondrial genome of Liriodendron could have such a slow mutation rate, and what it might tell us about the evolution of RNA editing.

Research article   Open Access Highly Accessed

The “fossilized” mitochondrial genome of Liriodendron tulipifera: ancestral gene content and order, ancestral editing sites, and extraordinarily low mutation rate

Aaron O Richardson, Danny W Rice, Gregory J Young, Andrew J Alverson, Jeffrey D Palmer BMC Biology 2013, 11:29 (15 April 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The mitochondrial genome of the tulip tree has a remarkably slow rate of nucleotide substitution, and could offer insight into the content and organisation of this genome in the ancestral flowering plant.

Commentary   Open Access Highly Accessed

Biological functions of natural antisense transcripts

Andreas Werner BMC Biology 2013, 11:31 (12 April 2013)

Abstract | Full text | PDF | PubMed

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