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Volume 2 (2004) - September 2004

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Research article   Open Access

Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins

Stanley M Gartler, Kartik R Varadarajan, Ping Luo, Theresa K Canfield, Jeff Traynor, Uta Francke, R Scott Hansen BMC Biology 2004, 2:21 (20 September 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Although in ICF syndrome cells the inactive X chromosome is hypomethylated, there is normal histone modification, suggesting that DNA methylation is not critical to histone modification: Rett syndrome cell data support this view.