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Volume 2 (2004) - November 2004

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Research article   Open Access

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

Dawn R Mattoon, Betty Lamothe, Irit Lax, Joseph Schlessinger BMC Biology 2004, 2:24 (18 November 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

When epidermal growth factor stimulates the AKT signalling pathway through its receptor, the docking protein Gab1 provides an essential link between the receptor and phosphatidylinositol-3 kinase, although a weaker alternative pathway bypasses Gab1.

Research article   Open Access Highly Accessed

Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation

Christina Kaiser, Stephen R James BMC Biology 2004, 2:23 (2 November 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Acetylation of IRS-1, a key moderator of insulin action, facilitates its tyrosine phosphorylation and insulin-stimulated signal transduction.


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