Volume 2 (2004) - November 2004
Dawn R Mattoon, Betty Lamothe, Irit Lax, Joseph Schlessinger BMC Biology 2004, 2:24 (18 November 2004)
When epidermal growth factor stimulates the AKT signalling pathway through its receptor, the docking protein Gab1 provides an essential link between the receptor and phosphatidylinositol-3 kinase, although a weaker alternative pathway bypasses Gab1.
Christina Kaiser, Stephen R James BMC Biology 2004, 2:23 (2 November 2004)
Acetylation of IRS-1, a key moderator of insulin action, facilitates its tyrosine phosphorylation and insulin-stimulated signal transduction.