BMC Biology is the flagship biology journal of the BMC series, publishing peer-reviewed research and methodology articles of special importance and broad interest in any area of biology, as well as commissioned reviews, opinion pieces, comment and Q&As on topics of special or topical interest.

Re-review opt-out In response to widespread frustration with delays to publication through iterative reviewing, we give our authors a choice (see our Editorial: Q&A: Re-review opt-out and painless publishing).


  • Miranda Robertson, BioMed Central
Beyond Mendel: modelling in biology -- a new series
Mitochondria: a cross-journal series
Open Questions


Selected articles

Review & comment

Open Access
  • Image credit: Deshaies, BMC Biology 2014

    Pushing tumor cells into proteostatic crisis

    Raymond Deshaies

    Most, if not all, tumors are at risk of getting fatally gummed up with mutant proteins that don’t fold properly, but very few succumb to proteasome inhibitors which should exploit this vulnerability. Raymond Deshaies asks why, and what might be done to broaden their lethality.

  • Image credit: Chandel, BMC Biology 2014

    Four requirements for metformin to arrest tumors

    Navdeep Chandel

    Navdeep Chandel explains in an interview why it has been difficult to establish whether the anti-diabetic drug metformin affects tumor growth, and how the properties of individual tumors may be crucial.

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    How metformin acts against cancer

    Alba Luengo, Lucas Sullivan, Matthew Heiden

    Commenting on a recent paper in Cancer and Metabolism, Matthew vander Heiden and colleagues consider the mechanisms by which the anti-diabetic drug metformin can act via mitochondria to combat cancer.

  • Image credit: Alice Plane, BMC Biology

    Cancer cell signaling: What goes wrong?

    H Wiley

    As the latest addition to our series of Open Questions, Steven Wiley focuses on the feedback controls on cell signaling and proliferation, and the need to understand how they are disrupted in cancer cells.


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Journal of Biology

BMC Biology assimilated the philosophy and distinguished Editorial Board and history of its sister journal Journal of Biology on fusion of the two journals in 2010. The full archive of Journal of Biology is available from its own archive website, and the objectives and aspirations of the combined journal are explained in the editorial that accompanied the fusion.

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ISSN: 1741-7007