- Hans-Joachim Anders, Ludwig-Maximilians-University
- Adrian Covic, Parhon University Hospital
- Michelle Estrella, Johns Hopkins School of Medicine
- Bernard Jaar, Johns Hopkins Medical Institutions
- William Oetting, University of Minnesota
- Giorgina Piccoli, University of Torino
- Donald S Silverberg, Tel Aviv Medical Center
- Robert Unwin, University College London
- Hayley Henderson, BioMed Central
Factors associated with need for chronic dialysis among survivors of severe AKI and who become dialysis independent include pre-existing CKD, hypertension and overall comorbidity, and the association between need for chronic dialysis persist after considering the competing risk of death.
Long-term prognosis of clinically early IgA nephropathy (IgAN) patients is not always favourable, even if presenting with benign manifestations; however, pathologic changes, including interstitial fibrosis can be important to predict renal risk progression.
Primary studies on the prevalence of CKD in Pakistan reveal that clinically significant chronic kidney disease (CKD) is common among adults, highlighting the need to integrate CKD prevention and management in the primary care infrastructure in Pakistan, and possibly neighbouring countries.
Validation of a novel immunosuppressive adverse effect scoring system applied to stable renal transplant recipients reveals could help to enhance individualization of immunosuppressive regimens, improve adherence to immunosuppressive medications and minimize adverse drug effects post-transplant.
Chronic kidney disease (CKD) is common in older adults prescribed metformin for type 2 diabetes, raising concern for potentially inappropriate medication use, and prompting greater consideration for mediation safety in this population due to prevalence of CKD.
Trends in parathyroidectomy (PTX) rates in the Swedish dialysis and transplant population reveals that increasing awareness of the benefits of PTX may be attributed to a rise in PTX rates, but increasing sales of cinacalcet coincide with a recent decline in rates.
Low documentation of CKD on the electronic problem list is associated with certain patient characteristics such as disease severity serum eGFR testing and urine protein testing; thus increasing documentation of CKD on the problem list could serve to improve stage-appropriate monitoring
Intermittent oral alfacalcidol administration during haemodialysis sessions is more effective than the equivalent IV dosage with a greater efficacy to reduce serum parathormone, presenting a more cost-efficient strategy over IV administration.
A combination of three different advanced electron microscopic techniques have helped to determine the structural basis of two additional layers of the Glomerular Filtration Barrier (GFB), which should allow identification of structural features regulating physiology, serving to better understand kidney disease.
David Gustafsson and Robert Unwin look into uric acid metabolism and review the current literature on the pathophysiology of hyperuricaemia, discussing its possible relationship to cardiovascular disease, morbidity and mortality and emerging treatment options.BMC Nephrology 2013, 14:164
BMC Nephrology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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William Oetting is currently a Professor in the Departments of Experimental and Clinical Pharmacology in the College of Pharmacy and Genetics, Cell Biology and Development at in the MedicalSchool at the University of Minnesota. Professor Oetting's research focuses on the genetic analysis of common diseases. In particular, the effects of genetic variation on kidney allograft health and survival for kidney transplant recipients. As genetic variants associated with kidney function and/or disease are identified, they will become candidates for other diseases which include the kidney. He is also interested in identifying proteomic and metabolomics markers associated with kidney health after transplantation.
"I am pleased to have been involved with BMC Nephrology, first as an Associate Editor and now as Section Editor for the Genetics section. I have been impressed with the journal's high editorial standards, and rapidity of the peer review and publication process. Moreover, I strongly believe in the value of BMC Nephrology's open access policy, which makes new knowledge available to the global nephrology community, irrespective of institutional affiliation or financial means.
The genetics section of BMC Nephrology will provide a forum for investigators who are interested in genetic variation and their impact on kidney development, function, disease and response to therapy. Kidney disease is the ninth leading cause of death in the United States. The variability between individuals with kidney disease on overall health (e.g. glomerular diseases), or on kidney health (e.g. type 2 diabetes), shows why understanding the genetics of kidney disease is important. I am looking forward to the many contributions associated with the genetics of kidney health and disease that will be published in BMC Nephrology."