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    New subtypes from existing prostate cancer signature

    Validation of an existing prostate cancer gene expression profile has identified two groups, associated with good or poor prognosis, rather than the previous four 4 subtypes, and highlights the importance of taking sample tissue composition into account.

    BMC Medical Genomics 2014, 7:50
  • Combining state-of-the-art methods pays off for PGS

    A combination of time-lapse monitoring of morphokinetic markers and array-CGH testing, results in improved rates of implantation and ongoing pregnancy for patients undergoing preimplantation genetic screening (PGS) over those in conventional incubators.

    BMC Medical Genomics 2014, 7:38
  • Image attributed to: Mate Marschalko, CCBY 2.0

    Blood will tell?

    A meta-analysis of brain studies shows that although a small proportion of eQTLs would be discovered by using blood as a surrogate for brain tissue, overlapping eQTLs are functionally similar, so  neurological and psychiatric studies using blood still have value.

    BMC Medical Genomics 2014, 7:31
  • Image attributed to: Mysi Ann on Flickr, CC BY-SA 2.0

    Dissection of psoriasis transcriptomes

    A meta-analysis of expression profiling and GWAS datasets in psoriasis, finds half the differentially expressed genes most highly expressed in skin cells, whereas GWAS candidates were most expressed in immune cells, particularly neutrophils.

    BMC Medical Genomics 2014, 7:27
  • Phenotypic approach to exome analysis

    A new program, PhenoVar, implements a phenotype-driven analysis of encrypted exome data in genetic diagnosis, circumventing some of the consent and ethical problems with incorporating exome sequencing in to the clinic.

    BMC Medical Genomics 2014, 7:22
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