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Research article   Open Access

Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy

Musaffe Tuna, Zhenlin Ju, Christopher I Amos, Gordon B Mills BMC Medical Genomics 2012, 5:60 (5 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Identification and characterization of alternative exon usage linked glioblastoma multiforme survival

Ahmed Sadeque, Nicola VL Serão, Bruce R Southey, Kristin R Delfino, Sandra L Rodriguez-Zas BMC Medical Genomics 2012, 5:59 (4 December 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A whole blood gene expression-based signature for smoking status

Philip Beineke, Karen Fitch, Heng Tao, Michael R Elashoff, Steven Rosenberg, William E Kraus, James A Wingrove, PREDICT Investigators BMC Medical Genomics 2012, 5:58 (3 December 2012)

Abstract | Full text | PDF | PubMed

Technical advance   Open Access Highly Accessed

Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies

Fuman Jiang, Jinghui Ren, Fang Chen, Yuqiu Zhou, Jiansheng Xie, Shan Dan, Yue Su, Jianhong Xie, Baomin Yin, Wen Su, Huakun Zhang, Wei Wang, Xianghua Chai, Linhua Lin, Hui Guo, Qiyun Li, Peipei Li, Yuying Yuan, Xiaoyu Pan, Yihan Li, Lifu Liu, Huifei Chen, Zhaoling Xuan, Shengpei Chen, Chunlei Zhang, Hongyun Zhang, Zhongming Tian, Zhengyu Zhang, Hui Jiang, Lijian Zhao, Weimou Zheng, Songgang Li, Yingrui Li, Jun Wang, Jian Wang, Xiuqing Zhang et al. BMC Medical Genomics 2012, 5:57 (1 December 2012)

Abstract | Full text | PDF | PubMed

Database   Open Access

Autworks: a cross-disease network biology application for Autism and related disorders

Tristan H Nelson, Jae-Yoon Jung, Todd F DeLuca, Byron K Hinebaugh, Kristian St Gabriel, Dennis P Wall BMC Medical Genomics 2012, 5:56 (28 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis

Françoise Bonnet, Mickael Guedj, Natalie Jones, Sana Sfar, Véronique Brouste, Nabila Elarouci, Guillaume Banneau, Béatrice Orsetti, Charlotte Primois, Christine Tunon de Lara, Marc Debled, Isabelle de Mascarel, Charles Theillet, Nicolas Sévenet, Aurélien de Reynies, Gaëtan MacGrogan, Michel Longy BMC Medical Genomics 2012, 5:54 (27 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Genomic signatures characterize leukocyte infiltration in myositis muscles

Wei Zhu, Katie Streicher, Nan Shen, Brandon W Higgs, Chris Morehouse, Lydia Greenlees, Anthony A Amato, Koustubh Ranade, Laura Richman, David Fiorentino, Bahija Jallal, Steven A Greenberg, Yihong Yao BMC Medical Genomics 2012, 5:53 (21 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization

Zhi-Zhou Shi, Yue-Ming Zhang, Li Shang, Jia-Jie Hao, Tong-Tong Zhang, Bo-Shi Wang, Jian-Wei Liang, Xi Chen, Ying Zhang, Gui-Qi Wang, Ming-Rong Wang, Yu Zhang BMC Medical Genomics 2012, 5:52 (16 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Cell Line Derived Multi-Gene Predictor of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Validation Study on US Oncology 02-103 Clinical Trial

Kui Shen, Yuan Qi, Nan Song, Chunqiao Tian, Shara D Rice, Michael J Gabrin, Stacey L Brower, William Fraser Symmans, Joyce A O’Shaughnessy, Frankie A Holmes, Lina Asmar, Lajos Pusztai BMC Medical Genomics 2012, 5:51 (16 November 2012)

Abstract | Full text | PDF | PubMed

Review   Open Access Highly Accessed

Completion of the swine genome will simplify the production of swine as a large animal biomedical model

Eric M Walters, Eckhard Wolf, Jeffery J Whyte, Jiude Mao, Simone Renner, Hiroshi Nagashima, Eiji Kobayashi, Jianguo Zhao, Kevin D Wells, John K Critser, Lela K Riley, Randall S Prather BMC Medical Genomics 2012, 5:55 (15 November 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Eric M Walters and colleagues review the pig as a large animal biomedical model and how the publication of the swine genome sequence will further advance its utility for understanding human disease, transgenesis and xenotransplantation.

Research article   Open Access Highly Accessed

A direct comparison of next generation sequencing enrichment methods using an aortopathy gene panel- clinical diagnostics perspective

Whitney L Wooderchak-Donahue, Brendan O’Fallon, Larissa V Furtado, Jacob D Durtschi, Parker Plant, Perry G Ridge, Alan F Rope, Angela T Yetman, Pinar Bayrak-Toydemir BMC Medical Genomics 2012, 5:50 (14 November 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study

Yingfang Tian, Boryana Stamova, Bradley P Ander, Glen C Jickling, Joan R Gunther, Blythe A Corbett, Netty GP Bos-Veneman, Pieter J Hoekstra, Julie B Schweitzer, Frank R Sharp BMC Medical Genomics 2012, 5:49 (30 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Integrative analysis of neuroblastoma and pheochromocytoma genomics data

Peter M Szabó, Miklós Pintér, Diana Szabó, Adrienn Zsippai, Attila Patócs, András Falus, Károly Rácz, Peter Igaz BMC Medical Genomics 2012, 5:48 (29 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Histotype-specific copy-number alterations in ovarian cancer

Ruby YunJu Huang, Geng Bo Chen, Noriomi Matsumura, Hung-Cheng Lai, Seiichi Mori, Jingjing Li, Meng Kang Wong, Ikuo Konishi, Jean-Paul Thiery, Liang Goh BMC Medical Genomics 2012, 5:47 (18 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Defining the genomic signature of the parous breast

Suraj Peri, Ricardo de Cicco, Julia Santucci-Pereira, Michael Slifker, Eric A Ross, Irma H Russo, Patricia A Russo, Alan A Arslan, Ilana Belitskaya-Lévy, Anne Zeleniuch-Jacquotte, Pal Bordas, Per Lenner, Janet Åhman, Yelena Afanasyeva, Robert Johansson, Fathima Sheriff, Göran Hallmans, Paolo Toniolo, Jose Russo BMC Medical Genomics 2012, 5:46 (11 October 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Post-menopausal women who have previously given birth show differential gene expression in breast tissue compared to those who have not, with the affected pathways in RNA splicing and processing potentially contributing to their lowered breast cancer risk

Debate   Open Access

Approaches to informed consent for hypothesis-testing and hypothesis-generating clinical genomics research

Flavia M Facio, Julie C Sapp, Amy Linn, Leslie G Biesecker BMC Medical Genomics 2012, 5:45 (10 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers

Roy RL Bastien, Álvaro Rodríguez-Lescure, Mark TW Ebbert, Aleix Prat, Blanca Munárriz, Leslie Rowe, Patricia Miller, Manuel Ruiz-Borrego, Daniel Anderson, Bradley Lyons, Isabel Álvarez, Tracy Dowell, David Wall, Miguel Seguí, Lee Barley, Kenneth M Boucher, Emilio Alba, Lisa Pappas, Carole A Davis, Ignacio Aranda, Christiane Fauron, Inge J Stijleman, José Palacios, Antonio Antón, Eva Carrasco, Rosalía Caballero, Matthew J Ellis, Torsten O Nielsen, Charles M Perou, Mark Astill, Philip S Bernard, Miguel Martín et al. BMC Medical Genomics 2012, 5:44 (4 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network

Xin Chen, Wei Jiang, Qianghu Wang, Teng Huang, Peng Wang, Yan Li, Xiaowen Chen, Yingli Lv, Xia Li BMC Medical Genomics 2012, 5:43 (2 October 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Candidate gene association study in pediatric acute lymphoblastic leukemia evaluated by Bayesian network based Bayesian multilevel analysis of relevance

Orsolya Lautner-Csorba, András Gézsi, Ágnes F Semsei, Péter Antal, Dániel J Erdélyi, Géza Schermann, Nóra Kutszegi, Katalin Csordás, Márta Hegyi, Gábor Kovács, András Falus, Csaba Szalai BMC Medical Genomics 2012, 5:42 (28 September 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Immune genes are associated with human glioblastoma pathology and patient survival

Elodie Vauléon, Avril Tony, Abderrahmane Hamlat, Amandine Etcheverry, Dan Chiforeanu, Philippe Menei, Jean Mosser, Véronique Quillien, Marc Aubry BMC Medical Genomics 2012, 5:41 (14 September 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer

Iver Nordentoft, Karin Birkenkamp-Demtroder, Mads Agerbæk, Dan Theodorescu, Marie Ostenfeld, Arndt Hartmann, Michael Borre, Torben F Ørntoft, Lars Dyrskjøt BMC Medical Genomics 2012, 5:40 (6 September 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles

Julia Tchou, Andrew V Kossenkov, Lisa Chang, Celine Satija, Meenhard Herlyn, Louise C Showe, Ellen Puré BMC Medical Genomics 2012, 5:39 (6 September 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice

Wilma T Steegenga, Nicole JW de Wit, Mark V Boekschoten, Noortje IJssennagger, Carolien Lute, Shohreh Keshtkar, Mechteld M Bromhaar, Ellen Kampman, Lisette C de Groot, Michael Muller BMC Medical Genomics 2012, 5:38 (28 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The small intestine and colons of aging mice do not show marked changes in expression of genes involved in metabolic processes, however immune response and inflammation gene expression increases and aging-induced global hypomethylation is also present.

Research article   Open Access

Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines

Hemant Kulkarni, Harald H H Göring, Vincent Diego, Shelley Cole, Ken R Walder, Greg R Collier, John Blangero, Melanie A Carless BMC Medical Genomics 2012, 5:37 (23 August 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Gankyrin gene deletion followed by proteomic analysis: insight into the roles of Gankyrin in Tumorigenesis and Metastasis

Xue Luo, Liang Chen, Jiang Dai, Yanfei Gao, Hongli Wang, Na Wang, Yongqiang Zhao, Feng Liu, Zhihong Sang, Jie Wang, Weihua Li, Kun He, Baofeng Jin, Jianghong Man, Wei Zhang, Qing Xia BMC Medical Genomics 2012, 5:36 (22 August 2012)

Abstract | Full text | PDF | PubMed

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