- Francisco Azuaje, Luxembourg Institute of Health
- Struan Grant, Children's Hospital of Philadelphia
- Patrick Tan, Graduate Medical School Singapore
- Pearlly Yan, The Ohio State University
- Tim Sands , BioMed Central
As genomic technology advances and more people access genomic information, terms describing DNA variation such as “mutation” and “polymorphism” are often becoming blurred; a new proposal originating from an online forum discussion recommends how to avoid confusion.
A new approach to identifying robust genes set to predict clinical outcomes uses a “gene set activity score” (GSAS) in a given patient, and is here applied to predict survival time in breast cancer patients.
The expression of 75 microRNAs in the prefrontal cortex of the brains of Huntingdon’s disease patients differed compared to healthy controls, suggesting a role, particularly for miR-10b-5p in Huntingdon’s pathogenicity, and are also potentially biomarkers
News from the web
- 30 September 2014
- Eight types of schizophrenia? Not so fast…
BMC Medical Genomics is an open access, peer-reviewed journal that considers articles on all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
BMC Medical Genomics is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.
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Following posts in the UK, Australia, Iceland and Germany, Struan Grant has been the Associate Director of the Center for Applied Genomics at the Children's Hospital of Philadelphia since 2006. His current work focuses on metabolic disease, with a specific focus on pediatrics. Utilizing high-throughput genotyping technology, his goals include isolating genes involved in obesity and bone strength. Both of these phenotypes are known to be strongly determined by genetic factors and distillation of this component should be easier to determine in children, where the relatively short period of their lifetime limits the impact of environmental exposure.
BMC series blog
- 27 August 2015
- Improving rice for the future: an author Q+A
- 26 August 2015
- Studying the world’s rarest ape: insights from the field
- 26 August 2015
- Behind the image: Incredible antennae
Volume 8 Suppl 2 (29 May 2015)
Selected articles from the 4th Translational Bioinformatics Conference and the 8th International Conference on Systems Biology (TBC/ISB 2014)
Qingdao, China. 24-27 October 2014