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Editor-in-Chief Melissa Norton, MD
Medical Editor Jigisha Patel, MRCP PhD
In-house Editor Scott Edmunds PhD
Welcome to BMC Medical Genomics published by BioMed Central
BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
BMC Medical Genomics (ISSN 1755-8794) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Thomson Reuters (ISI) and Google Scholar.
Featured articles
BMC Medical Genomics 2009, 2 :62
Treating lymphoblastic cell lines derived from schizophrenia patients with glucose deprivation and combining exon array, mRNA and genotyping analysis identifies stress related exon-specific expression changes and SNP variants potentially linked to this psychological disorder.
BMC Medical Genomics 2009, 2 :54
Combining global microRNA and mRNA expression data indicates MiR-125a is over-expressed in the liver of hyperglycaemic rats and is a putative modulator of glucose and lipid metabolism in a rat model of type 2 diabetes.
BMC Medical Genomics 2009, 2 :37
Activation of growth factor (GF) signalling contributes to the tamoxifen-insensitive estrogen receptor-positive breast cancer phenotype independent of human epidermal growth factor receptor (HER2) gene expression, suggesting an alternative therapeutic target for this aggressive disease.
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Research article
Accurate molecular classification of cancer using simple rules Xiaosheng Wang, Osamu Gotoh BMC Medical Genomics 2009, 2 :64 (30 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity B BMC Medical Genomics 2009, 2 :63 (2 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation Maureen V Martin, Brandi Rollins, P Adolfo Sequeira, Andrea Mes BMC Medical Genomics 2009, 2 :62 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Discovering cancer genes by integrating network and functional properties Li Li, Kangyu Zhang, James Lee, Shaun Cordes, David P Davis, Zhijun Tang BMC Medical Genomics 2009, 2 :61 (19 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Transcriptional profiling differences for articular cartilage and repair tissue in equine joint surface lesions Michael J Mienaltowski, Liping Huang, David D Frisbie, C Wayne McIlwraith, Arnold J Stromberg, Arne C Bathke, James N MacLeod BMC Medical Genomics 2009, 2 :60 (14 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family Sandeep Sanga, Bradley M Broom, Vittorio Cristini, Mary E Edgerton BMC Medical Genomics 2009, 2 :59 (11 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells Alissar Nehm BMC Medical Genomics 2009, 2 :58 (10 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Evaluation of a new high-dimensional miRNA profiling platform Julie M Cunningham, Ann L Oberg, Pedro M Borralho, Betsy T Kren, Amy J French, Liang Wang, Brian M Bot, Bruce W Morlan, Kevin AT Silverstein, Rod Staggs, Yan Zeng, Anne-Francoise Lamblin, Christopher A Hilker, Jian-Bing Fan, Clifford J Steer, Stephen N Thibodeau BMC Medical Genomics 2009, 2 :57 (27 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke Sabina Halappanavar, Marsha Russell, Martin R Stampfli, Andrew Williams, Carole L Yauk BMC Medical Genomics 2009, 2 :56 (21 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells Hongjuan Zhao, Vincent Flamand, Donna M Peehl BMC Medical Genomics 2009, 2 :55 (20 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Review
Pathophysiology of vascular dementia Francesco Iemolo MD, Giovanni Duro DR, Claudia Rizzo MD, Laura Castiglia DR, Vladimir Hachinski MD, Calogero Caruso MD Immunity & Ageing 2009, 6 :13 (6 [Abstract ] [Provisional PDF ]
Commentary
Multiple sclerosis: major histocompatibility complexity and antigen presentation Sreeram V Ramagopalan, George C Ebers Genome Med 2009, 1 :105 (6 [Abstract ] [Full text ] [PDF ]
Research article
STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect Sean P Pitroda, Bassam T Wakim, Ravi F Sood, Mara G Beveridge, Michael A Beckett, Dhara M MacDermed, Ralph R Weichselbaum, Nikolai N Khodarev BMC Medicine 2009, 7 :68 (5 [Abstract ] [Provisional PDF ]
Musings
Musings on genome medicine: Crohn's disease David G Nathan, Stuart H Orkin Genome Med 2009, 1 :103 (5 [Abstract ] [Full text ] [PDF ]
Meeting report
Complex disease genetics: present and future translational applications Michael V Holmes, Sonia H Shah, Aspasia Angelakopoulou, Tauseef Khan, Daniel Swerdlow, Karoline Kuchenbaecker, Reecha Sofat, Tina Shah Genome Med 2009, 1 :104 (5 [Abstract ] [Full text ] [PDF ]
Methodology
Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancer Laura Casorzo, Mara Corigliano, Paolo Ferrero, Tiziana Venesio, Mauro Risio Diagnostic Pathology 2009, 4 :36 (4 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Commentary
The Infectious Diseases BioBank at King's College London: archiving samples from patients infected with HIV to facilitate translational research Rachel Williams, Christine Mant, John Cason Retrovirology 2009, 6 :98 (3 [Abstract ] [Provisional PDF ]
Review
Genetic overlap between autism, schizophrenia and bipolar disorder Liam S Carroll, Michael J Owen Genome Med 2009, 1 :102 (30 [Abstract ] [Full text ] [PDF ]
Research article
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward Pawel K Olszewski, Robert Fredriksson, Agnieszka M Olszewska, Olga Stephansson, Johan Alsi BMC Neuroscience 2009, 10 :129 (27 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Minireview
Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies Durga Udayakumar, Hensin Tsao Genome Med 2009, 1 :95 (27 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
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, Katarzyna J Radomska, Allen S Levine, Helgi B Schi