- Francisco Azuaje, Luxembourg Institute of Health
- Struan Grant, Children's Hospital of Philadelphia
- Patrick Tan, Graduate Medical School Singapore
- Pearlly Yan, The Ohio State University
- Tim Sands , BioMed Central
A new approach to identifying robust genes set to predict clinical outcomes uses a “gene set activity score” (GSAS) in a given patient, and is here applied to predict survival time in breast cancer patients.
The expression of 75 microRNAs in the prefrontal cortex of the brains of Huntingdon’s disease patients differed compared to healthy controls, suggesting a role, particularly for miR-10b-5p in Huntingdon’s pathogenicity, and are also potentially biomarkers
Individuals with methamphetamine dependence treated with the drug topimirate—a treatment for alcoholism—those who respond to the drug show different gene expression patterns in processes underlying addiction compared to non-responders and those treated with placebos.
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- 30 September 2014
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BMC Medical Genomics is an open access, peer-reviewed journal that considers articles on all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
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Following posts in the UK, Australia, Iceland and Germany, Struan Grant has been the Associate Director of the Center for Applied Genomics at the Children's Hospital of Philadelphia since 2006. His current work focuses on metabolic disease, with a specific focus on pediatrics. Utilizing high-throughput genotyping technology, his goals include isolating genes involved in obesity and bone strength. Both of these phenotypes are known to be strongly determined by genetic factors and distillation of this component should be easier to determine in children, where the relatively short period of their lifetime limits the impact of environmental exposure.
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Volume 8 Suppl 1 (15 January 2015)
Selected articles from the 2nd International Genomic Medicine Conference (IGMC 2013): Medical Genomics
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Sydney, Australia. 31 July - 2 August 2014