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Editor-in-Chief Melissa Norton, MD
Medical Editor Jigisha Patel, MRCP PhD
In-house Editor Scott Edmunds, PhD
Welcome to BMC Medical Genomics published by BioMed Central
BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.
BMC Medical Genomics (ISSN 1755-8794) is indexed/tracked/covered by PubMed, BIOSIS, CAS and Google Scholar.
BMC Medical Genomics 2009, 2 :37
Activation of growth factor (GF) signalling contributes to the tamoxifen-insensitive estrogen receptor-positive breast cancer phenotype independent of human epidermal growth factor receptor (HER2) gene expression, suggesting an alternative therapeutic target for this aggressive disease.
BMC Medical Genomics 2009, 2 :35
Analysis of breast cancer and adjacent tissue using deep-sequencing technology and a novel computational pipeline identifies 5 new microRNAs, and indicates that sequence end variability may be used as a discriminatory feature to aid future microRNA discovery.
BMC Medical Genomics 2009, 2 :26
The RIC8A gene is identified as a putative breast cancer tumor-suppressor by a novel combination of array-CGH with non-sense mediated mRNA decay and gene expression data, and shows association with aggressive TP53 mutant tumors in vitro.
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Research article
The Gene expression Grade Index: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial Christine Desmedt, Anita Giobbie-Hurder, Patrick Neven, Robert Paridaens, Marie-Rose Christiaens, Ann Smeets, Francoise Lallemand, Benjamin Haibe-Kains, Giuseppe Viale, Richard D. Gelber, Martine Piccart, Christos Sotiriou BMC Medical Genomics 2009, 2 :40 (2 [Abstract ] [Provisional PDF ]
Research article
NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines Tineke E Buffart, Marianne Tijssen, Jamila El-Bchiri, Alex Duval, Mark A van de Wiel, Bauke Ylstra, Gerrit A Meijer, Beatriz Carvalho BMC Medical Genomics 2009, 2 :39 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
A Gene Signature for Post-Infectious Chronic Fatigue Syndrome John W Gow, Suzanne Hagan, Pawel Herzyk, Celia Cannon, Peter O Behan, Abhijit Chaudhuri BMC Medical Genomics 2009, 2 :38 (25 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer Sherene Loi, Christos Sotiriou, Benjamin Haibe-Kains, Francoise Lallemand, Nelly M Conus, Martine J Piccart, Terence P Speed, Grant A McArthur BMC Medical Genomics 2009, 2 :37 (24 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
MLL rearrangements in pediatric acute lymphoblastic and myeloblastic leukemias: MLL specific and lineage specific signatures Andrea Zangrando, Marta Campo Dell'Orto, Geertruy TE Kronnie, Giuseppe Basso BMC Medical Genomics 2009, 2 :36 (23 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing Sanne Nygaard, Anders Jacobsen, Morten Lindow, Jens Eriksen, Eva Balslev, Henrik Flyger, Niels Tolstrup, S BMC Medical Genomics 2009, 2 :35 (9 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer Meng Li, Curt Balch, John S Montgomery, Mikyoung Jeong, Jae Hoon Chung, Pearlly Yan, Tim H-M Huang, Sun Kim, Kenneth P Nephew BMC Medical Genomics 2009, 2 :34 (8 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
A longitudinal study of gene expression in healthy individuals Chris Karlovich, Guillemette Duchateau-Nguyen, Andrea Johnson, Patricia McLoughlin, Mercidita Navarro, Carole Fleurbaey, Lori Steiner, Michel Tessier, Tracy Nguyen, Monika Wilhelm-Seiler, John P Caulfield BMC Medical Genomics 2009, 2 :33 (7 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck Saskia M Wilting, Serge J Smeets, Peter JF Snijders, Wessel N van Wieringen, Mark A van de Wiel, Gerrit A Meijer, Bauke Ylstra, C Ren BMC Medical Genomics 2009, 2 :32 (1 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Identification of gene co-regulatory modules and associated cis- elements involved in degenerative heart disease Charles G Danko, Arkady M Pertsov BMC Medical Genomics 2009, 2 :31 (28 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Minireview
Exploring the unknown: assumptions about allelic architecture and strategies for susceptibility variant discovery Mark I McCarthy Genome Med 2009, 1 :66 (3 [Abstract ] [Full text ] [PDF ]
Research
The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias Luke B Hesson, Thomas L Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D Chalmers, Eamonn R Maher, Farida Latif Molecular Cancer 2009, 8 :42 (1 [Abstract ] [Provisional PDF ]
Research article
Clique-based data mining for related genes in a biomedical database Tsutomu Matsunaga, Chikara Yonemori, Etsuji Tomita, Masaaki Muramatsu BMC Bioinformatics 2009, 10 :205 (1 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia Thierry Lequerre, Carine Bansard, Olivier Vittecoq, Celine Derambure, Martine Hiron, Maryvonne Daveau, Francois Tron, Xavier Ayral, Norman Biga, Isabelle Auquit-Auckbur, Gilles Chiocchia, Xavier Le Loet, Jean-Philippe Salier Arthritis Research & Therapy 2009, 11 :R99 (29 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Minireview
Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis Marylyn D Ritchie Genome Med 2009, 1 :65 (29 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Commentary
Translational bioinformatics applications in genome medicine Atul J Butte Genome Med 2009, 1 :64 (29 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Identification of proteins involved in neural progenitor cell targeting of gliomas
Karin Staflin, Thole Zuchner, Gabriella Honeth, Anna Darabi, Cecilia Lundberg BMC Cancer 2009, 9 :206 (26 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Impact of animal strain on gene expression in a rat model of acute cardiac rejection Katherine J Deans, Peter C Minneci, Hao Chen, Steven J Kern, Carolea Logun, Sara Alsaaty, Kelly J Norsworthy, Stephanie M Theel, Joel D Sennesh, Jennifer J Barb, Peter J Munson, Robert L Danner, Michael A Solomon BMC Genomics 2009, 10 :280 (24 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth Hiroaki Mita, Minoru Toyota, Fumio Aoki, Hirofumi Akashi, Reo Maruyama, Yasushi Sasaki, Hiromu Suzuki, Masashi Idogawa, Lisa Kashima, Kazuyoshi Yanagihara, Masahiro Fujita, Masao Hosokawa, Masanobu Kusano, Sorin VASILE Sabau, Haruyuki Tatsumi, Kohzoh Imai, Yasuhisa Shinomura, Takashi Tokino BMC Cancer 2009, 9 :198 (23 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Review
Genomic and post-genomic analyses of human prion diseases Maurizio Pocchiari, Anna Poleggi, Serena Principe, Silvia Graziano, Franco Cardone Genome Med 2009, 1 :63 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
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