- Peter-Bram 't Hoen, Leiden University Medical Center
- Shane C Burgess, University of Arizona
- David Burt, University of Edinburgh
- John K Colbourne, The University of Birmingham
- Ivo G Gut, Centro Nacional de Analisis Genomico, Barcelona
- Scott E Hemby, Wake Forest University
- Hans Lehrach, Max Planck Institute for Molecular Genetics
- David Lightfoot, Southern Illinois University at Carbondale
- Paul Pavlidis, University of British Columbia
- Daniel Sargent, Fondazione Edmund Mach - IASMA
- Leonard Schalkwyk, King's College London
- Fabiano Thompson, UFRJ
- Stefan Wiemann, German Cancer Research Center
- Derek Anane, BioMed Central
PIRM syndrome casts a number of morbidities on finnish Ayrshire cattle including retardation and mortality. Following an exhaustive GWAS the syndrome has been traced to a G>A mutation caused by In frame exon skipping.
The genetic underpinnings of susceptibility to Klebsiella pneumonaie are poorly understood. Following a large scale QTL investigation utilising over 70 collaborative cross mice lines 3 loci have been identified important for susceptibility.
Zebrafish display a unique ability to regenerate heart tissue. In the present study, transcripts expressed in response to cardiac damage were identified using a range of techniques which may be useful in the future treatment of cardiac diseases.
Comparative analysis of genes from the recently discovered hemicellulose hydrolytic locus from Geobacillus have revealed a number of variances. This discovery provides a blueprint for the development of Geobacillus species able to degrade a wide variety of cellulose containing bio waste.
Giant spider crabs experience an increase in expression of stress related genes at intermediate ocean acidification levels whilst this effect is attenuated at higher levels. This may leave the species vulnerable to increasing ocean acidification.
Following mating female fruit flies experience decreased lifespans in relation to their non-mated cohorts. Through assessing genome wide mRNA microRNAs and histone modifications, microRNAs have been implicated as the major driving force of this phenotypic plasticity.
In their open peer reviewed correspondence piece, Tagu and colleagues discuss the opportunities afforded by neoENCODE initiatives to understand how genetic systems react in the natural context of living ecosystems. Do comment!
RNA-seq and proteomic analysis uncover 695 black widow venom gland-specific transcripts, including putative unknown toxins and a high diversity of associate proteins, suggestive of a rapid evolutionary expansion of the toxin arsenal in these spiders.
BMC Genomics 2014, 15:914
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BMC Genomics is an open access, peer-reviewed journal that considers articles on all aspects of genome-scale analysis, functional genomics, and proteomics.
BMC Genomics is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.
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Volume 15 Suppl 6 (17 October 2014)
Proceedings of the Twelfth Annual Research in Computational Molecular Biology (RECOMB) Satellite Workshop on Comparative Genomics
Cold Spring Harbor, NY, USA. 19-22 October 2014
Volume 15 Suppl 5 (14 July 2014)
Selected articles from the Third IEEE International Conference on Computational Advances in Bio and Medical Sciences (ICCABS 2013): Genomics
New Orleans, LA, USA. 12-14 June 2013
Volume 15 Suppl 4 (20 May 2014)
SNP-SIG 2013: Identification and annotation of genetic variants in the context of structure, function, and disease
Berlin, Germany. 19 July 2013