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1.

934
Accesses

Review   Open Access Highly Accessed

Candidate gene association studies: a comprehensive guide to useful in silico tools

Radhika Patnala, Judith Clements, Jyotsna Batra BMC Genetics 2013, 14:39 (9 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A review of computational tools to select candidate genes for association studies provides a user-friendly guide to help identify disease-associated genetic variants, aimed particularly for use in the medical and cancer research communities.

2.

771
Accesses

Research article   Open Access

Genome-wide association study for backfat thickness in Canchim beef cattle using Random Forest approach

Fabiana Mokry, Roberto Higa, Maurício de Alvarenga Mudadu, Andressa Oliveira de Lima, Sarah Laguna Meirelles, Marcos Vinicius Barbosa da Silva, Fernando Cardoso, Maurício Morgado de Oliveira, Ismael Urbinati, Simone Méo Niciura, Rymer Tullio, Maurício Mello de Alencar, Luciana Correia de Almeida Regitano BMC Genetics 2013, 14:47 (5 June 2013)

Abstract | Full text | PDF | ePUB | PubMed

3.

678
Accesses

Research article   Open Access

Characterization of a dopamine transporter polymorphism and behavior in Belgian Malinois

Lisa Lit, Janelle M Belanger, Debby Boehm, Nathan Lybarger, Anouck Haverbeke, Claire Diederich, Anita M Oberbauer BMC Genetics 2013, 14:45 (30 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

4.

614
Accesses

Methodology article   Open Access Highly Accessed

Discriminant analysis of principal components: a new method for the analysis of genetically structured populations

Thibaut Jombart, Sébastien Devillard, François Balloux BMC Genetics 2010, 11:94 (15 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology |  Editor’s summary

A new multivariate method for the analysis of genetically structured populations, Discriminant Analysis of Principal Components (DAPC), is better able to characterize population subdivision, and performs faster, than current Bayesian clustering algorithms.

5.

611
Accesses

Research article   Open Access

Reintroductions and genetic introgression from domestic pigs have shaped the genetic population structure of Northwest European wild boar

Daniel J Goedbloed, Pim van Hooft, Hendrik-Jan Megens, Katharina Langenbeck, Walburga Lutz, Richard PMA Crooijmans, Sip E van Wieren, Ron C Ydenberg, Herbert HT Prins BMC Genetics 2013, 14:43 (20 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

6.

614
Accesses

Research article   Open Access Highly Accessed

Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

Ripudaman K Bains, Mirna Kovacevic, Christopher A Plaster, Ayele Tarekegn, Endashaw Bekele, Neil N Bradman, Mark G Thomas BMC Genetics 2013, 14:34 (3 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

Variability in the gene encoding the drug metabolizing enzyme Cytochrome P450 3A5 (CYP3A5) from 36 ethnically diverse populations in Africa reveals that 43% of individuals express this gene, consistent with it playing a role in salt-retention.

7.

564
Accesses

Research article   Open Access

Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height

Yuri T Utsunomiya, Adriana S do Carmo, Roberto Carvalheiro, Haroldo HR Neves, Márcia C Matos, Ludmilla B Zavarez, Ana M Pérez O’Brien, Johann Sölkner, John C McEwan, John B Cole, Curtis P Van Tassell, Flávio S Schenkel, Marcos VGB da Silva, Laercio R Porto Neto, Tad S Sonstegard, José F Garcia BMC Genetics 2013, 14:52 (13 June 2013)

Abstract | Full text | PDF | PubMed

8.

538
Accesses

Research article   Open Access Highly Accessed

Assessment of clinical analytical sensitivity and specificity of next-generation sequencing for detection of simple and complex mutations

Ephrem LH Chin, Cristina da Silva, Madhuri Hegde BMC Genetics 2013, 14:6 (19 February 2013)

Abstract | Full text | PDF | PubMed

9.

533
Accesses

Methodology article   Open Access

iXora: Exact haplotype inferencing and trait association

Filippo Utro, Niina Haiminen, Donald Livingstone, Omar E Cornejo, Stefan Royaert, Raymond J Schnell, Juan Carlos Motamayor, David N Kuhn, Laxmi Parida BMC Genetics 2013, 14:48 (6 June 2013)

Abstract | Provisional PDF | PubMed

10.

502
Accesses

Research article   Open Access

Genetic variation in polyploid forage grass: Assessing the molecular genetic variability in the Paspalum genus

Fernanda W Cidade, Bianca BZ Vigna, Francisco HD de Souza, José Francisco M Valls, Miguel Dall’Agnol, Maria I Zucchi, Tatiana T de Souza-Chies, Anete P Souza BMC Genetics 2013, 14:50 (8 June 2013)

Abstract | Full text | PDF | PubMed

11.

464
Accesses

Research article   Open Access

Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel loci

Antònia Flaquer, Clemens Baumbach, Estefania Piñero, Fernando García Algas, María de la Fuente Sanchez, Jordi Rosell, Jorge Toquero, Luis Alonso-Pulpon, Pablo Garcia-Pavia, Konstantin Strauch, Damian Heine-Suñer BMC Genetics 2013, 14:44 (24 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

12.

461
Accesses

Research article   Open Access

Fine mapping of fatness QTL on porcine chromosome X and analyses of three positional candidate genes

Junwu Ma, Hélène Gilbert, Nathalie Iannuccelli, Yanyu Duan, Beili Guo, Weibing Huang, Huanban Ma, Juliette Riquet, Jean-Pierre Bidanel, Lusheng Huang, Denis Milan BMC Genetics 2013, 14:46 (1 June 2013)

Abstract | Provisional PDF | PubMed

13.

417
Accesses

Research article   Open Access

Discovery of single nucleotide polymorphisms in candidate genes associated with fertility and production traits in Holstein cattle

Sarah D Cochran, John B Cole, Daniel J Null, Peter J Hansen BMC Genetics 2013, 14:49 (7 June 2013)

Abstract | Provisional PDF | PubMed

14.

362
Accesses

Research article   Open Access

Linking the potato genome to the conserved ortholog set (COS) markers

Hannele Lindqvist-Kreuze, Kwangsoo Cho, Leticia Portal, Flor Rodríguez, Reinhard Simon, Lukas A Mueller, David M Spooner, Meredith Bonierbale BMC Genetics 2013, 14:51 (8 June 2013)

Abstract | Provisional PDF | PubMed

15.

379
Accesses

Research article   Open Access Highly Accessed

Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans

Mait Metspalu, Toomas Kivisild, Ene Metspalu, Jüri Parik, Georgi Hudjashov, Katrin Kaldma, Piia Serk, Monika Karmin, Doron M Behar, M Thomas P Gilbert, Phillip Endicott, Sarabjit Mastana, Surinder S Papiha, Karl Skorecki, Antonio Torroni, Richard Villems BMC Genetics 2004, 5:26 (31 August 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

365
Accesses

Research article   Open Access Highly Accessed

Genetic determinants of hair and eye colours in the Scottish and Danish populations

Jonas Mengel-From, Terence H Wong, Niels Morling, Jonathan L Rees, Ian J Jackson BMC Genetics 2009, 10:88 (30 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Scottish and Danish populations are famed for being ‘redheads' and a study of 33 genes shows that red hair color is associated with polymorphisms in melanin pigmentation and albinism genes, such as MC1R.

17.

347
Accesses

Methodology article   Open Access

Detecting negative selection on recurrent mutations using gene genealogy

Kiyoshi Ezawa, Giddy Landan, Dan Graur BMC Genetics 2013, 14:37 (7 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

18.

319
Accesses

Research article   Open Access

Can DNA barcoding accurately discriminate megadiverse Neotropical freshwater fish fauna?

Luiz HG Pereira, Robert Hanner, Fausto Foresti, Claudio Oliveira BMC Genetics 2013, 14:20 (9 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

19.

331
Accesses

Research article   Open Access Highly Accessed

Stability of genomic imprinting in human induced pluripotent stem cells

Hitoshi Hiura, Masashi Toyoda, Hiroaki Okae, Masahiro Sakurai, Naoko Miyauchi, Akiko Sato, Nobutaka Kiyokawa, Hajime Okita, Yoshitaka Miyagawa, Hidenori Akutsu, Koichiro Nishino, Akihiro Umezawa, Takahiro Arima BMC Genetics 2013, 14:32 (30 April 2013)

Abstract | Provisional PDF | PubMed

20.

306
Accesses

Software   Open Access

CpGPAP: CpG island predictor analysis platform

Li-Yeh Chuang, Cheng-Huei Yang, Ming-Cheng Lin, Cheng-Hong Yang BMC Genetics 2012, 13:13 (2 March 2012)

Abstract | Full text | PDF | PubMed

21.

281
Accesses

Methodology article   Open Access Highly Accessed

Disentangling molecular relationships with a causal inference test

Joshua Millstein, Bin Zhang, Jun Zhu, Eric E Schadt BMC Genetics 2009, 10:23 (27 May 2009)

Abstract | Full text | PDF | PubMed

22.

311
Accesses

Research article   Open Access

The juvenile alopecia mutation (jal) maps to mouse Chromosome 2, and is an allele of GATA binding protein 3 (Gata3)

Francisco Ramirez, Aaron M Feliciano, Elisabeth B Adkins, Kevin M Child, Legairre A Radden II, Alexis Salas, Nelson Vila-Santana, José M Horák, Samantha R Hughes, Damek V Spacek, Thomas R King BMC Genetics 2013, 14:40 (9 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

23.

296
Accesses

Research article   Open Access

Molecular cloning and characterization of the porcine prostaglandin transporter (SLCO2A1): evaluation of its role in F4 mediated neonatal diarrhoea

Mario Van Poucke, Vesna Melkebeek, Tim Erkens, Alex Van Zeveren, Eric Cox, Luc J Peelman BMC Genetics 2009, 10:64 (6 October 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

290
Accesses

Research article   Open Access Highly Accessed

Male-like sexual behavior of female mouse lacking fucose mutarotase

Dongkyu Park, Dongwook Choi, Junghoon Lee, Dae-sik Lim, Chankyu Park BMC Genetics 2010, 11:62 (7 July 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Female mice that lack the fucose mutarotase (FucM) gene exhibit male-like sexual behavior and have less tyrosine hydroxylase positive neurons in the preoptic region of the brain than wild-type mice.

25.

296
Accesses

Research article   Open Access

Genome-wide association study of antibody response to Newcastle disease virus in chicken

Chenglong Luo, Hao Qu, Jie Ma, Jie Wang, Chunyu Li, Chunfen Yang, Xiaoxiang Hu, Ning Li, Dingming Shu BMC Genetics 2013, 14:42 (10 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

26.

284
Accesses

Research article   Open Access Highly Accessed

Major genomic mitochondrial lineages delineate early human expansions

Nicole Maca-Meyer, Ana M González, José M Larruga, Carlos Flores, Vicente M Cabrera BMC Genetics 2001, 2:13 (13 August 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Analysis of 42 complete mitochondrial DNA sequences confirms that humans migrated eastwards from Africa some 60,000 years ago. Later, a western Asian population spread to many areas, including Europe and India, and also returned to Africa.

27.

288
Accesses

Research article   Open Access

Accuracy of the unified approach in maternally influenced traits - illustrated by a simulation study in the honey bee (Apis mellifera)

Pooja Gupta, Norbert Reinsch, Andreas Spötter, Tim Conrad, Kaspar Bienefeld BMC Genetics 2013, 14:36 (6 May 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

The unified approach for estimating breeding values for maternally influenced traits in honey bees is an accurate and useful methodology for genetic evaluation, especially for traits of apicultural interest such as resistance to Varroa mites.

28.

337
Accesses

Research article   Open Access Highly Accessed

Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions

Khaled K Abu-Amero, Ali Hellani, Ana M González, Jose M Larruga, Vicente M Cabrera, Peter A Underhill BMC Genetics 2009, 10:59 (22 September 2009)

Abstract | Full text | PDF | PubMed

29.

253
Accesses

Research article   Open Access

Breed, sex and anatomical location-specific gene expression profiling of the porcine skeletal muscles

Jie Zhang, Chaowei Zhou, Jideng Ma, Lei Chen, Anan Jiang, Li Zhu, Surong Shuai, Jinyong Wang, Mingzhou Li, Xuewei Li BMC Genetics 2013, 14:53 (15 June 2013)

Abstract | Provisional PDF

30.

275
Accesses

Software   Open Access Highly Accessed

PGA: power calculator for case-control genetic association analyses

Idan Menashe, Philip S Rosenberg, Bingshu E Chen BMC Genetics 2008, 9:36 (13 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Power for Genetic Association analyses (PGA) is a new user-friendly software package for calculating statistical power, in particular sample size and minimum detectable risk, in case-control genetic-association studies using SNP markers in unrelated subjects.

31.

271
Accesses

Research article   Open Access Highly Accessed

Genetic variation in South Indian castes: evidence from Y-chromosome, mitochondrial, and autosomal polymorphisms

WS Watkins, R Thara, BJ Mowry, Y Zhang, DJ Witherspoon, W Tolpinrud, MJ Bamshad, S Tirupati, R Padmavati, H Smith, D Nancarrow, C Filippich, LB Jorde BMC Genetics 2008, 9:86 (12 December 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The effects of both historical migrations and the caste system are reflected in the genetic structure of Y-chromosomes, autosomes and mitochondrial DNA in two populations from Tamil Nadu and Andhra Pradesh in southern India.

32.

266
Accesses

Research article   Open Access Highly Accessed

Insertion-deletion polymorphisms (indels) as genetic markers in natural populations

Ülo Väli, Mikael Brandström, Malin Johansson, Hans Ellegren BMC Genetics 2008, 9:8 (22 January 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

33.

261
Accesses

Methodology article   Open Access Highly Accessed

High throughput whole rumen metagenome profiling using untargeted massively parallel sequencing

Elizabeth M Ross, Peter J Moate, Carolyn R Bath, Sophie E Davidson, Tim I Sawbridge, Kathryn M Guthridge, Ben G Cocks, Ben J Hayes BMC Genetics 2012, 13:53 (2 July 2012)

Abstract | Full text | PDF | PubMed

34.

274
Accesses

Research article   Open Access

Genotype imputation accuracy in a F2 pig population using high density and low density SNP panels

Jose L Gualdrón Duarte, Ronald O Bates, Catherine W Ernst, Nancy E Raney, Rodolfo JC Cantet, Juan P Steibel BMC Genetics 2013, 14:38 (8 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

35.

258
Accesses

Research article   Open Access Highly Accessed

Genetic evidence supports linguistic affinity of Mlabri - a hunter-gatherer group in Thailand

Shuhua Xu, Daoroong Kangwanpong, Mark Seielstad, Metawee Srikummool, Jatupol Kampuansai, Li Jin, The HUGO Pan-Asian SNP Consortium* BMC Genetics 2010, 11:18 (19 March 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment

36.

267
Accesses

Research article   Open Access Highly Accessed

SNP identification, verification, and utility for population genetics in a non-model genus

Larissa M Williams, Xin Ma, Adam R Boyko, Carlos D Bustamante, Marjorie F Oleksiak BMC Genetics 2010, 11:32 (30 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

37.

256
Accesses

Research article   Open Access

Genome-wide association study of infectious bovine keratoconjunctivitis in Angus cattle

Kadir Kizilkaya, Richard G Tait, Dorian J Garrick, Rohan L Fernando, James M Reecy BMC Genetics 2013, 14:23 (26 March 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A genome-wide association study in Angus cattle to detect susceptibility to infectious bovine keratoconjunctivitis (pinkeye) identifies several SNPs in linkage disequilibrium with the phenotype, which may lead to identification of causative genetic variants.

38.

240
Accesses

Research article   Open Access Highly Accessed

Mitochondrial DNA haplogroup H structure in North Africa

Hajer Ennafaa, Vicente M Cabrera, Khaled K Abu-Amero, Ana M González, Mohamed B Amor, Rym Bouhaha, Nduna Dzimiri, Amel B Elgaaïed, José M Larruga BMC Genetics 2009, 10:8 (25 February 2009)

Abstract | Full text | PDF | PubMed

39.

244
Accesses

Research article   Open Access Highly Accessed

Simultaneous SNP identification and assessment of allele-specific bias from ChIP-seq data

Yunyun Ni, Amelia Weber Hall, Anna Battenhouse, Vishwanath R Iyer BMC Genetics 2012, 13:46 (5 September 2012)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A new approach to simultaneously discover SNPs and perform transcription factor binding bias analysis using ChIP-seq data generated in the ENCODE Project reveals widespread heritable allele-specific binding and significant enrichment for disease-associated variants.

40.

243
Accesses

Research article   Open Access

Variants in the 3' UTR of General Transcription Factor IIF, polypeptide 2 affect female calving efficiency in Japanese Black cattle

Shinji Sasaki, Takayuki Ibi, Toshio Watanabe, Tamako Matsuhashi, Shogo Ikeda, Yoshikazu Sugimoto BMC Genetics 2013, 14:41 (10 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

41.

236
Accesses

Research article   Open Access Highly Accessed

A genetic dissection of breed composition and performance enhancement in the Alaskan sled dog

Heather J Huson, Heidi G Parker, Jonathan Runstadler, Elaine A Ostrander BMC Genetics 2010, 11:71 (22 July 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Alaskan sled dog has been bred for performance rather than appearance and its genetic profile is comprised of several different lineages that have influenced the speed, endurance, and work ethic of this particular dog breed.

42.

230
Accesses

Research article   Open Access Highly Accessed

Genetic affinities among the lower castes and tribal groups of India: inference from Y chromosome and mitochondrial DNA

Ismail Thanseem, Kumarasamy Thangaraj, Gyaneshwer Chaubey, Vijay Singh, Lakkakula VKS Bhaskar, B Mohan Reddy, Alla G Reddy, Lalji Singh BMC Genetics 2006, 7:42 (7 August 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 2 comments

43.

226
Accesses

Research article   Open Access Highly Accessed

Gene-Based Single Nucleotide Polymorphism Markers for Genetic and Association Mapping in Common Bean

Carlos H Galeano, Andrés J Cortés, Andrea C Fernández, Álvaro Soler, Natalia Franco-Herrera, Godwill Makunde, Jos Vanderleyden, Matthew W Blair BMC Genetics 2012, 13:48 (26 June 2012)

Abstract | Full text | PDF | PubMed | 1 comment

44.

212
Accesses

Research article   Open Access Highly Accessed

Genotype – environment correlations in corals from the Great Barrier Reef

Petra Lundgren, Juan C Vera, Lesa Peplow, Stephanie Manel, Madeleine JH van Oppen BMC Genetics 2013, 14:9 (22 February 2013)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Significant correlations between environmental factors and genetic polymorphisms in two species of reef-building coral on the Great Barrier Reef provides a first step toward identifying populations that could be robust to future climatic change. 

45.

211
Accesses

Research article   Open Access Highly Accessed

Runs of homozygosity and population history in cattle

Deirdre C Purfield, Donagh P Berry, Sinead McParland, Daniel G Bradley BMC Genetics 2012, 13:70 (14 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

46.

210
Accesses

Research article   Open Access

Evolutionary history of black grouse major histocompatibility complex class IIB genes revealed through single locus sequence-based genotyping

Tanja Strand, Biao Wang, Yvonne Meyer-Lucht, Jacob Höglund BMC Genetics 2013, 14:29 (24 April 2013)

Abstract | Full text | PDF | ePUB | PubMed |  Editor’s summary

A powerful single locus genotyping method for amplifying MHC class IIB loci in black grouse indicate that duplication of the BLB gene occurred before the species diverged from chickens and pheasants.

47.

204
Accesses

Research article   Open Access Highly Accessed

Historically low mitochondrial DNA diversity in koalas (Phascolarctos cinereus)

Kyriakos Tsangaras, María C Ávila-Arcos, Yasuko Ishida, Kristofer M Helgen, Alfred L Roca, Alex D Greenwood BMC Genetics 2012, 13:92 (24 October 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Comparing museum specimens with modern populations reveals little evidence that hunting of koalas in the early 20th century caused the low genetic diversity currently seen in this species, suggesting a more ancient factor is to blame.

48.

177
Accesses

Research article   Open Access

DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle

David A Magee, Klaudia M Sikora, Erik W Berkowicz, Donagh P Berry, Dawn J Howard, Michael P Mullen, Ross D Evans, Charles Spillane, David E MacHugh BMC Genetics 2010, 11:93 (13 October 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

49.

194
Accesses

Research article   Open Access Highly Accessed

SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines

Ada Ching, Katherine S Caldwell, Mark Jung, Maurine Dolan, Oscar Smith, Scott Tingey, Michele Morgante, Antoni J Rafalski BMC Genetics 2002, 3:19 (7 October 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

50.

198
Accesses

Research article   Open Access

Conservation of the COP9/signalosome in budding yeast

Susan Wee, Bettina Hetfeld, Wolfgang Dubiel, Dieter A Wolf BMC Genetics 2002, 3:15 (20 August 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The disruption of budding yeast genes that encode proteins interacting with a putative subunit of the COP9/signalosome provides evidence that this multiprotein complex is present and functional in budding yeast, as well as many metazoans.

51.

186
Accesses

Research article   Open Access

Genetic map of Triticum turgidum based on a hexaploid wheat population without genetic recombination for D genome

Li Zhang, Jiang-Tao Luo, Ming Hao, Lian-Quan Zhang, Zhong-Wei Yuan, Ze-Hong Yan, Ya-Xi Liu, Bo Zhang, Bao-Long Liu, Chun-Ji Liu, Huai-Gang Zhang, You-Liang Zheng, Deng-Cai Liu BMC Genetics 2012, 13:69 (13 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

52.

191
Accesses

Research article   Open Access Highly Accessed

Comparative analysis of copy number variation detection methods and database construction

Asako Koike, Nao Nishida, Daiki Yamashita, Katsushi Tokunaga BMC Genetics 2011, 12:29 (7 March 2011)

Abstract | Full text | PDF | PubMed

53.

190
Accesses

Research article   Open Access Highly Accessed

qDTY1.1 , a major QTL for rice grain yield under reproductive-stage drought stress with a consistent effect in multiple elite genetic backgrounds

Prashant Vikram, BP Swamy, Shalabh Dixit, Helal Ahmed, Ma Teresa Sta Cruz, Alok Singh, Arvind Kumar BMC Genetics 2011, 12:89 (18 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

54.

186
Accesses

Research article   Open Access Highly Accessed

Long term persistence of clonal malaria parasite Plasmodium falciparum lineages in the Colombian Pacific region

Diego F Echeverry, Shalini Nair, Lyda Osorio, Sanjay Menon, Claribel Murillo, Tim JC Anderson BMC Genetics 2013, 14:2 (7 January 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Analysis of Plasmodium falciparum parasites from malaria patients in Colombia reveals strong subdivision and long-term persistence of clonal populations, highlighting that these aspects of population structure should be taken into account when designing drug resistance studies.

55.

183
Accesses

Research article   Open Access Highly Accessed

A comparison of statistical methods for genomic selection in a mice population

Haroldo HR Neves, Roberto Carvalheiro, Sandra A Queiroz BMC Genetics 2012, 13:100 (8 November 2012)

Abstract | Full text | PDF | PubMed | 1 comment

56.

186
Accesses

Research article   Open Access

A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance

Monique Ohanian, David T Humphreys, Elizabeth Anderson, Thomas Preiss, Diane Fatkin BMC Genetics 2013, 14:18 (6 March 2013)

Abstract | Full text | PDF | PubMed

57.

176
Accesses

Research article   Open Access

Genome-wide associations for milk production and somatic cell score in Holstein-Friesian cattle in Ireland

Brian K Meredith, Francis J Kearney, Emma K Finlay, Daniel G Bradley, Alan G Fahey, Donagh P Berry, David J Lynn BMC Genetics 2012, 13:21 (26 March 2012)

Abstract | Full text | PDF | PubMed

58.

177
Accesses

Research article   Open Access

Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets

Maggie M Ho, Piriya Yoganathan, Kwan Chu, Subashini Karunakaran, James D Johnson, Susanne M Clee BMC Genetics 2013, 14:10 (25 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

59.

179
Accesses

Research article   Open Access

Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis

Wilfred Wu, Erin A S Clark, Gregory J Stoddard, W Scott Watkins, M Sean Esplin, Tracy A Manuck, Jinchuan Xing, Michael W Varner, Lynn B Jorde BMC Genetics 2013, 14:30 (25 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

60.

176
Accesses

Research article   Open Access Highly Accessed

Power analysis for genome-wide association studies

Robert J Klein BMC Genetics 2007, 8:58 (28 August 2007)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The statistical power of genome-wide association studies may be increased by a new method for calculating their power, which can help improve study designs by determining optimal combinations of tagSNP markers and sample size.

61.

179
Accesses

Research article   Open Access

Molecular mapping of QTLs for plant type and earliness traits in pigeonpea (Cajanus cajan L. Millsp.)

Giriraj Kumawat, Ranjeet S Raje, Shefali Bhutani, Jitendra K Pal, Amitha SVCR Mithra, Kishor Gaikwad, Tilak R Sharma, Nagendra K Singh BMC Genetics 2012, 13:84 (8 October 2012)

Abstract | Full text | PDF | PubMed

62.

178
Accesses

Methodology article   Open Access

A new set of BXD recombinant inbred lines from advanced intercross populations in mice

Jeremy L Peirce, Lu Lu, Jing Gu, Lee M Silver, Robert W Williams BMC Genetics 2004, 5:7 (29 April 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A new panel of recombinant inbred mouse strains produced from two independent advanced intercrosses between C57BL/6J and DBA/2J progenitor strains bred for multiple generations provides a new resource for collaborative analysis of quantitative traits and gene function.

63.

170
Accesses

Research article   Open Access Highly Accessed

A comparison of SNP and STR loci for delineating population structure and performing individual genetic assignment

Kevin A Glover, Michael M Hansen, Sigbjørn Lien, Thomas D Als, Bjørn Høyheim, Øystein Skaala BMC Genetics 2010, 11:2 (6 January 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

64.

178
Accesses

Research article   Open Access

AB-QTL analysis reveals new alleles associated to proline accumulation and leaf wilting under drought stress conditions in barley (Hordeum vulgare L.)

Mohammed A Sayed, Henrik Schumann, Klaus Pillen, Ali A Naz, Jens Léon BMC Genetics 2012, 13:61 (20 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Genetic effects on coat colour in cattle: dilution of eumelanin and phaeomelanin pigments in an F2-Backcross Charolais × Holstein population

Beatriz Gutiérrez-Gil, Pamela Wiener, John L Williams BMC Genetics 2007, 8:56 (16 August 2007)

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175
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Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

Ute Philipp, Henning Hamann, Lars Mecklenburg, Seiji Nishino, Emmanuel Mignot, Anne-Rose Günzel-Apel, Sheila M Schmutz, Tosso Leeb BMC Genetics 2005, 6:34 (16 June 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels

Rami Nassir, Roman Kosoy, Chao Tian, Phoebe A White, Lesley M Butler, Gabriel Silva, Rick Kittles, Marta E Alarcon-Riquelme, Peter K Gregersen, John W Belmont, Francisco M De La Vega, Michael F Seldin BMC Genetics 2009, 10:39 (24 July 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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159
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Genetic diversity and relationships in mulberry (genus Morus) as revealed by RAPD and ISSR marker assays

Arvind K Awasthi, GM Nagaraja, GV Naik, Sriramana Kanginakudru, K Thangavelu, Javaregowda Nagaraju BMC Genetics 2004, 5:1 (10 January 2004)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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A simple method for estimating genetic diversity in large populations from finite sample sizes

Stanislav Bashalkhanov, Madhav Pandey, Om P Rajora BMC Genetics 2009, 10:84 (16 December 2009)

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Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition

Mohammad Hossein Moradi, Ardeshir Nejati-Javaremi, Mohammad Moradi-Shahrbabak, Ken G Dodds, John C McEwan BMC Genetics 2012, 13:10 (26 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Three novel regions associated with fat deposition in thin and fat tailed sheep have been identified from a genome-wide scan of selective sweeps using 50,000 SNPs from the Ovine HapMap project

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Genome-level identification, gene expression, and comparative analysis of porcine ß-defensin genes

Min-Kyeung Choi, Minh Le, Dinh Nguyen, Hojun Choi, Won Kim, Jin-Hoi Kim, Jungwan Chun, Jiyeon Hyeon, Kunho Seo, Chankyu Park BMC Genetics 2012, 13:98 (15 November 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Comparative analysis of beta-defensin genes in the pig genome shows structural conservation of syntenic regions compared with humans and cattle, with 29 porcine beta-defensin (pBD) genelike sequences identified, 17 of which are previously unreported in the porcine genome.

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Research article   Open Access

Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study

Kira C Taylor, Cara L Carty, Logan Dumitrescu, Petra Bůžková, Shelley A Cole, Lucia Hindorff, Fred R Schumacher, Lynne R Wilkens, Ralph V Shohet, P Quibrera, Karen C Johnson, Brian E Henderson, Jeff Haessler, Nora Franceschini, Charles B Eaton, David J Duggan, Barbara Cochran, Iona Cheng, Chris S Carlson, Kristin Brown-Gentry, Garnet Anderson, Jose Ambite, Christopher Haiman, Loïc Le Marchand, Charles Kooperberg, Dana C Crawford, Steven Buyske, Kari E North, Myriam Fornage, for the PAGE Study et al. BMC Genetics 2013, 14:33 (1 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

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Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

Deanna S Cross, Lynn C Ivacic, Elisha L Stefanski, Catherine A McCarty BMC Genetics 2010, 11:51 (17 June 2010)

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Research article   Open Access

Identification of Lens culinaris defense genes responsive to the anthracnose pathogen Colletotrichum truncatum

Vijai Bhadauria, Kirstin E Bett, Tengsheng Zhou, Albert Vandenberg, Yangdou Wei, Sabine Banniza BMC Genetics 2013, 14:31 (30 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

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Genomic microsatellites identify shared Jewish ancestry intermediate between Middle Eastern and European populations

Naama M Kopelman, Lewi Stone, Chaolong Wang, Dov Gefel, Marcus W Feldman, Jossi Hillel, Noah A Rosenberg BMC Genetics 2009, 10:80 (8 December 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | 1 comment |  Editor’s summary

Analysis of autosomal microsatellite loci in four Jewish populations shows a high level of similarity between them, and supports a largely Middle Eastern ancestry with varying degrees of admixture with European populations.

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Research article   Open Access

MHC polymorphism and disease resistance to vibrio anguillarum in 8 families of half-smooth tongue sole (Cynoglossus semilaevis)

Min Du, Song-lin Chen, Yan-hong Liu, Yang Liu, Jing-feng Yang BMC Genetics 2011, 12:78 (2 September 2011)

Abstract | Full text | PDF | PubMed | 1 comment

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Genetic structure of Indian populations based on fifteen autosomal microsatellite loci

VK Kashyap, Saurav Guha, T Sitalaximi, G Hima Bindu, Seyed E Hasnain, R Trivedi BMC Genetics 2006, 7:28 (17 May 2006)

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Prevalence of common disease-associated variants in Asian Indians

Trevor J Pemberton, Niyati U Mehta, David Witonsky, Anna Di Rienzo, Hooman Allayee, David V Conti, Pragna I Patel BMC Genetics 2008, 9:13 (4 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Spatial and temporal variation in population genetic structure of wild Nile tilapia (Oreochromis niloticus) across Africa

Etienne Bezault, Patricia Balaresque, Aboubacar Toguyeni, Yves Fermon, Hitoshi Araki, Jean-François Baroiller, Xavier Rognon BMC Genetics 2011, 12:102 (9 December 2011)

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Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis

Jennifer L Zechel, Stephanie K Doerner, Angela Lager, Paul J Tesar, Jason D Heaney, Joseph H Nadeau BMC Genetics 2013, 14:54 (17 June 2013)

Abstract | Provisional PDF

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ISSR markers show differentiation among Italian populations of Asparagus acutifolius L

Maria Sica, Graziella Gamba, Stefania Montieri, Luciano Gaudio, Serena Aceto BMC Genetics 2005, 6:17 (18 March 2005)

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Quantitative Trait Locus (QTL) meta-analysis and comparative genomics for candidate gene prediction in perennial ryegrass (Lolium perenne L.)

Hiroshi Shinozuka, Noel OI Cogan, German C Spangenberg, John W Forster BMC Genetics 2012, 13:101 (8 November 2012)

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A novel linkage map of sugarcane with evidence for clustering of retrotransposon-based markers

Alessandra C Palhares, Taislene B Rodrigues-Morais, Marie-Anne Van Sluys, Douglas S Domingues, Walter Maccheroni, Hamilton Jordão, Anete P Souza, Thiago G Marconi, Marcelo Mollinari, Rodrigo Gazaffi, Antonio Augusto F Garcia, Maria Lucia Vieira BMC Genetics 2012, 13:51 (28 June 2012)

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Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A y allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss

Jun-ichi Suto, Kunio Satou BMC Genetics 2013, 14:35 (4 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

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Isolation by distance, web service

Jeffrey L Jensen, Andrew J Bohonak, Scott T Kelley BMC Genetics 2005, 6:13 (11 March 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Genetic dissection of rice grain shape using a recombinant inbred line population derived from two contrasting parents and fine mapping a pleiotropic quantitative trait locus qGL7

Xufeng Bai, Lijun Luo, Wenhao Yan, Mallikarjuna Rao Kovi, Wei Zhan, Yongzhong Xing BMC Genetics 2010, 11:16 (26 February 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Genetic affinities between the Yami tribe people of Orchid Island and the Philippine Islanders of the Batanes archipelago

Jun-Hun Loo, Jean A Trejaut, Ju-Chen Yen, Zong-Sian Chen, Chien-Liang Lee, Marie Lin BMC Genetics 2011, 12:21 (31 January 2011)

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Culture creates genetic structure in the Caucasus: Autosomal, mitochondrial, and Y-chromosomal variation in Daghestan

Elizabeth E Marchani, W Scott Watkins, Kazima Bulayeva, Henry C Harpending, Lynn B Jorde BMC Genetics 2008, 9:47 (17 July 2008)

Abstract | Full text | PDF | PubMed | 1 comment

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Identification of candidate genes of QTLs for seed weight in Brassica napus through comparative mapping among Arabidopsis and Brassica species

Guangqin Cai, Qingyong Yang, Qian Yang, Zhenxing Zhao, Hao Chen, Jian Wu, Chuchuan Fan, Yongming Zhou BMC Genetics 2012, 13:105 (6 December 2012)

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GWAPower: a statistical power calculation software for genome-wide association studies with quantitative traits

Sheng Feng, Shengchu Wang, Chia-Cheng Chen, Lan Lan BMC Genetics 2011, 12:12 (21 January 2011)

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Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping

Adam B Olshen, Bert Gold, Kirk E Lohmueller, Jeffery P Struewing, Jaya Satagopan, Stefan A Stefanov, Eleazar Eskin, Tomas Kirchhoff, James A Lautenberger, Robert J Klein, Eitan Friedman, Larry Norton, Nathan A Ellis, Agnes Viale, Catherine S Lee, Patrick I Borgen, Andrew G Clark, Kenneth Offit, Jeff Boyd BMC Genetics 2008, 9:14 (5 February 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Proechimys (Rodentia, Echimyidae): characterization and taxonomic considerations of a form with a very low diploid number and a multiple sex chromosome system

Paulo JS Amaral, Cleusa Y Nagamachi, Renata CR Noronha, Marlyson JR Costa, Adenilson L Pereira, Rogerio V Rossi, Ana C Mendes-Oliveira, Julio C Pieczarka BMC Genetics 2013, 14:21 (11 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

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Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38

Julie A Mennella, M Yanina Pepino, Fujiko F Duke, Danielle R Reed BMC Genetics 2010, 11:60 (1 July 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Variation at the TAS2R38 locus is associated with bitter tasting ability; children with a heterozygous polymorphism in this taste receptor gene are more sensitive to bitterness than adults of the same haplotype.

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A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter size in sheep

Dag I Våge, Maren Husdal, Matthew P Kent, Gunnar Klemetsdal, Inger A Boman BMC Genetics 2013, 14:1 (2 January 2013)

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An assessment of population structure in eight breeds of cattle using a whole genome SNP panel

Stephanie D McKay, Robert D Schnabel, Brenda M Murdoch, Lakshmi K Matukumalli, Jan Aerts, Wouter Coppieters, Denny Crews, Emmanuel Neto, Clare A Gill, Chuan Gao, Hideyuki Mannen, Zhiquan Wang, Curt P Van Tassell, John L Williams, Jeremy F Taylor, Stephen S Moore BMC Genetics 2008, 9:37 (20 May 2008)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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Empirical evaluation of humpback whale telomere length estimates; quality control and factors causing variability in the singleplex and multiplex qPCR methods

Morten Olsen, Martine Bérubé, Jooke Robbins, Per J Palsbøll BMC Genetics 2012, 13:77 (6 September 2012)

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RHD positive haplotypes in D negative Europeans

Franz F Wagner, Alexander Frohmajer, Willy A Flegel BMC Genetics 2001, 2:10 (16 July 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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qDTY 12.1 : a locus with a consistent effect on grain yield under drought in rice

Krishna Kumar Mishra, Prashant Vikram, Ram Baran Yadaw, BP Mallikarjuna Swamy, Shalabh Dixit, Ma Teresa Sta Cruz, Paul Maturan, Shailesh Marker, Arvind Kumar BMC Genetics 2013, 14:12 (26 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

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Methods of tagSNP selection and other variables affecting imputation accuracy in swine

Yvonne M Badke, Ronald O Bates, Catherine W Ernst, Clint Schwab, Justin Fix, Curtis P Van Tassell, Juan P Steibel BMC Genetics 2013, 14:8 (21 February 2013)

Abstract | Provisional PDF | PubMed

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Methodology article   Open Access Highly Accessed

Genotyping faecal samples of Bengal tiger Panthera tigris tigris for population estimation: A pilot study

Jyotsna Bhagavatula, Lalji Singh BMC Genetics 2006, 7:48 (17 October 2006)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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