Chondromodulin-I localizes to the feto-maternal interface.Chondromodulin-I (ChM-I) is a naturally occurring anti-angiogenic glycoprotein that localizes to the avascular domains of mesenchymal tissues such as cartilage, cardiac valves, and the eye. In situ hybridization and immunohistochemistry experiments show that ChM-I also localizes to the decidualized uterus of pregnant mice, at the maternal interface to fetal trophoblasts, where it seems to regulate tissue remodeling and angiogenesis. Shown are cryo-sections of uterus tissues immunostained with anti-ChM-I antibody (in green). Blood vessels in the decidua are stained with anti-PECAM-1 antibody (in red) whereas the central dark zone represents the embryo.
Taken from: Yuji Hiraki et al., 2011, BMC Cell Biology [View article]
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