BMP signaling directs muscle satellite cell fateThe osteogenic effect of bone morphogenetic proteins (BMPs) has been mainly studied in C2C12 cells, a cell line derived from regenerating muscle. Unlike the myogenic C2C12 cell line, primary mouse satellite cells do not differentiate into osteoblasts upon BMP signaling. Instead, BMP signaling is shown to play a crucial role in maintaining primary muscle satellite cell descendants in a proliferating state, while cell cycle exit and differentiation into myotubes is induced by inhibition of BMP signaling. Double immuno-labeling of the myoblast lineage marker Desmin (in red) and the differentiation marker Myogenin (in green) in satellite cells treated with the inhibitor of BMP signaling Noggin shows enhanced myotube formation. Cell nuclei are counter-stained with DAPI (in blue).
Taken from: Andrea Vortkamp et al., 2011, BMC Cell Biology [View article]
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