Localization of formin family member formin-like 2 (FMNL2) in human cancer cells
Diaphanous-related formins play a role in cell movement and invasion; however, the role of formin family member formin -like 2 (FMNL2) in human tissues is unclear. To examine the role of FMNL2 in a squamous cell carcinoma (A431 human cell line), cells were stained with an FMNL2 antibody (red). FMNL2 had a cytoplasmic distribution and perinuclear accumulation, consistent with localization to the Golgi. A431 cells do not have cell protrusions, therefore, no co-localization with F-actin was evident. Cells were visualized by confocal microscopy and stained with an antibody to F-actin (green) and DAPI (blue), to stain the nucleus.
This information is for Figure 4
Taken from: Maria Gardberg et al., 2010, BMC Cell Biology [View article]
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