α5β1 integrin functional block in MLP29 hepatic progenitor cells
. Integrins have a major role in cell adhesion to the extracellular matrix and seem to be involved in cell migration. The functional blockade of α5β1 integrin in MLP29 hepatic progenitor cells induces cell migration accompanied by over-expression of markers of stem and progenitor cells and nuclear reorganization. Immunofluorescent detection of F-actin in a cell treated with the α5β1-functional blocking antibody shows the characteristic actin microfilaments reorientation associated with cytoskeleton re-organization (cyan). The nucleus is stained with DAPI (blue).
This information is for Figure 2, part A
Taken from: Luis Antonio Parada et al., 2010, BMC Cell Biology [View article]