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Transcriptome analysis

This section incorporates all aspects of transcriptomic analysis including but not limited to: methods and applications for the analysis of microarray and RNA-seq data.

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51.

Research article   Open Access

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs

Suleiman A Khan, Ali Faisal, John Mpindi, Juuso A Parkkinen, Tuomo Kalliokoski, Antti Poso, Olli P Kallioniemi, Krister Wennerberg, Samuel Kaski BMC Bioinformatics 2012, 13:112 (30 May 2012)

Abstract | Full text | PDF | PubMed

52.

Software   Open Access Highly Accessed

Workflows for microarray data processing in the Kepler environment

Thomas Stropp, Timothy McPhillips, Bertram Ludäscher, Mark Bieda BMC Bioinformatics 2012, 13:102 (17 May 2012)

Abstract | Full text | PDF | PubMed

53.

Software   Open Access

Augmented annotation and orthologue analysis for Oryctolagus cuniculus: Better Bunny

Douglas B Craig, Sujatha Kannan, Alan A Dombkowski BMC Bioinformatics 2012, 13:84 (8 May 2012)

Abstract | Full text | PDF | PubMed

54.

Methodology article   Open Access

False discovery rate control in two-stage designs

Sonja Zehetmayer, Martin Posch BMC Bioinformatics 2012, 13:81 (6 May 2012)

Abstract | Full text | PDF | PubMed

55.

Research article   Open Access Highly Accessed

A unified computational model for revealing and predicting subtle subtypes of cancers

Xianwen Ren, Yong Wang, Jiguang Wang, Xiang-Sun Zhang BMC Bioinformatics 2012, 13:70 (1 May 2012)

Abstract | Full text | PDF | PubMed

56.

Research article   Open Access Highly Accessed

Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: With application to major depressive disorder

Xingbin Wang, Yan Lin, Chi Song, Etienne Sibille, George C Tseng BMC Bioinformatics 2012, 13:52 (29 March 2012)

Abstract | Full text | PDF | PubMed

57.

Software   Open Access Highly Accessed

miRTrail - a comprehensive webserver for analyzing gene and miRNA patterns to enhance the understanding of regulatory mechanisms in diseases

Cedric Laczny, Petra Leidinger, Jan Haas, Nicole Ludwig, Christina Backes, Andreas Gerasch, Michael Kaufmann, Britta Vogel, Hugo A Katus, Benjamin Meder, Cord Stähler, Eckart Meese, Hans-Peter Lenhof, Andreas Keller BMC Bioinformatics 2012, 13:36 (22 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

58.

Software   Open Access Highly Accessed

ICGE: an R package for detecting relevant clusters and atypical units in gene expression

Itziar Irigoien, Basilio Sierra, Concepcion Arenas BMC Bioinformatics 2012, 13:30 (13 February 2012)

Abstract | Full text | PDF | PubMed

59.

Research article   Open Access Highly Accessed

Independent Principal Component Analysis for biologically meaningful dimension reduction of large biological data sets

Fangzhou Yao, Jeff Coquery, Kim-Anh Lê Cao BMC Bioinformatics 2012, 13:24 (3 February 2012)

Abstract | Full text | PDF | PubMed

60.

Software   Open Access Highly Accessed

An integrative variant analysis suite for whole exome next-generation sequencing data

Danny Challis, Jin Yu, Uday S Evani, Andrew R Jackson, Sameer Paithankar, Cristian Coarfa, Aleksandar Milosavljevic, Richard A Gibbs, Fuli Yu BMC Bioinformatics 2012, 13:8 (12 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Atlas2 is an analysis suite for variant calling in whole exome sequencing that combines regression models and user-adjustable cutoffs in order to separate true SNPs and INDELs from sequencing and mapping errors, with high sensitivity

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