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Volume 6 (2005) - April 2005

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Methodology article   Open Access

Some statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the Drosophila genome: the fluffy-tail test

Irina Abnizova, Rene te Boekhorst, Klaudia Walter, Walter R Gilks BMC Bioinformatics 2005, 6:109 (27 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Scoredist: A simple and robust protein sequence distance estimator

Erik LL Sonnhammer, Volker Hollich BMC Bioinformatics 2005, 6:108 (27 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements

Scott L Carter, Aron C Eklund, Brigham H Mecham, Isaac S Kohane, Zoltan Szallasi BMC Bioinformatics 2005, 6:107 (25 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Quadratic regression analysis for gene discovery and pattern recognition for non-cyclic short time-course microarray experiments

Hua Liu, Sergey Tarima, Aaron S Borders, Thomas V Getchell, Marilyn L Getchell, Arnold J Stromberg BMC Bioinformatics 2005, 6:106 (25 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Detailed protein sequence alignment based on Spectral Similarity Score (SSS)

Kshitiz Gupta, Dina Thomas, SV Vidya, KV Venkatesh, S Ramakumar BMC Bioinformatics 2005, 6:105 (23 April 2005)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Inspired by music database retrieval systems, this algorithm establishes spectral similarity between two amino acid sequences based on 256 attributes, detecting local variations and sub-sequence similarities that character-based algorithms miss.

Research article   Open Access

A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models

Nikolaos G Sgourakis, Pantelis G Bagos, Panagiotis K Papasaikas, Stavros J Hamodrakas BMC Bioinformatics 2005, 6:104 (22 April 2005)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access

Using co-occurrence network structure to extract synonymous gene and protein names from MEDLINE abstracts

AM Cohen, WR Hersh, C Dubay, K Spackman BMC Bioinformatics 2005, 6:103 (22 April 2005)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Evolutionary distance estimation and fidelity of pair wise sequence alignment

Michael S Rosenberg BMC Bioinformatics 2005, 6:102 (19 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access Highly Accessed

MARS: Microarray analysis, retrieval, and storage system

Michael Maurer, Robert Molidor, Alexander Sturn, Juergen Hartler, Hubert Hackl, Gernot Stocker, Andreas Prokesch, Marcel Scheideler, Zlatko Trajanoski BMC Bioinformatics 2005, 6:101 (18 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The MARS suite for microarray data is fully MIAME compliant, and provides a lab notebook and laboratory information management system, integrated with a pipeline of image analysis, normalization, gene expression clustering and pathway mapping.

Research article   Open Access

Filtering high-throughput protein-protein interaction data using a combination of genomic features

Ashwini Patil, Haruki Nakamura BMC Bioinformatics 2005, 6:100 (18 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Gene ontology annotations, sequence alignment and structural information of Pfam domains have been combined to create a method of validating high-thoroughput protein-protein interaction data that functions with a sensitivity of 90% and specificity of 63%.

Research article   Open Access

Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER

Markus Wistrand, Erik LL Sonnhammer BMC Bioinformatics 2005, 6:99 (15 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

ProGenExpress: Visualization of quantitative data on prokaryotic genomes

Michael Watson BMC Bioinformatics 2005, 6:98 (13 April 2005)

Abstract | Full text | PDF | PubMed | 2 comments

Research article   Open Access

Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker discovery

Leslie R Grate BMC Bioinformatics 2005, 6:97 (13 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

PREP-Mt: predictive RNA editor for plant mitochondrial genes

Jeffrey P Mower BMC Bioinformatics 2005, 6:96 (12 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

Statistical Viewer: a tool to upload and integrate linkage and association data as plots displayed within the Ensembl genome browser

Judith E Stenger, Hong Xu, Carol Haynes, Elizabeth R Hauser, Margaret Pericak-Vance, Pascal J Goldschmidt-Clermont, Jeffery M Vance BMC Bioinformatics 2005, 6:95 (12 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

'PACLIMS': A component LIM system for high-throughput functional genomic analysis

Nicole Donofrio, Ravi Rajagopalon, Douglas Brown, Stephen Diener, Donald Windham, Shelly Nolin, Anna Floyd, Thomas Mitchell, Natalia Galadima, Sara Tucker, Marc J Orbach, Gayatri Patel, Mark Farman, Vishal Pampanwar, Cari Soderlund, Yong-Hwan Lee, Ralph A Dean BMC Bioinformatics 2005, 6:94 (12 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

Windows .NET Network Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST)

Scot E Dowd, Joaquin Zaragoza, Javier R Rodriguez, Melvin J Oliver, Paxton R Payton BMC Bioinformatics 2005, 6:93 (8 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

W.ND-BLAST allows an increase in the performance of BLAST by distributing queries across a local area network, providing an intuitive GUI for database creation, search execution, output evaluation, and result exportation.

Research article   Open Access

Shortest triplet clustering: reconstructing large phylogenies using representative sets

Le Sy Vinh, Arndt von Haeseler BMC Bioinformatics 2005, 6:92 (8 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

A restraint molecular dynamics and simulated annealing approach for protein homology modeling utilizing mean angles

Andreas Möglich, Daniel Weinfurtner, Till Maurer, Wolfram Gronwald, Hans Kalbitzer BMC Bioinformatics 2005, 6:91 (8 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access

Individual sequences in large sets of gene sequences may be distinguished efficiently by combinations of shared sub-sequences

Mark J Gibbs, John S Armstrong, Adrian J Gibbs BMC Bioinformatics 2005, 6:90 (8 April 2005)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access Highly Accessed

A method for aligning RNA secondary structures and its application to RNA motif detection

Jianghui Liu, Jason TL Wang, Jun Hu, Bin Tian BMC Bioinformatics 2005, 6:89 (7 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

RSmatch aligns structures and identifies functional motifs by decomposing RNA secondary structures into sets of atomic structure components, finding the optimal global and local alignments using two scoring matrices.

Methodology article   Open Access Highly Accessed

Building a protein name dictionary from full text: a machine learning term extraction approach

Lei Shi, Fabien Campagne BMC Bioinformatics 2005, 6:88 (7 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A data mining approach, collecting high frequency terms in full text and using machine learning to identify biological terms, is used to construct a protein name dictionary which recognises many name variants not found in SwissProt.

Methodology article   Open Access

Workflows in bioinformatics: meta-analysis and prototype implementation of a workflow generator

Alexander Garcia Castro, Samuel Thoraval, Leyla J Garcia, Mark A Ragan BMC Bioinformatics 2005, 6:87 (7 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access

HDBStat!: A platform-independent software suite for statistical analysis of high dimensional biology data

Prinal Trivedi, Jode W Edwards, Jelai Wang, Gary L Gadbury, Vinodh Srinivasasainagendra, Stanislav O Zakharkin, Kyoungmi Kim, Tapan Mehta, Jacob PL Brand, Amit Patki, Grier P Page, David B Allison BMC Bioinformatics 2005, 6:86 (6 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Software   Open Access Highly Accessed

CGHPRO – A comprehensive data analysis tool for array CGH

Wei Chen, Fikret Erdogan, H-Hilger Ropers, Steffen Lenzner, Reinhard Ullmann BMC Bioinformatics 2005, 6:85 (5 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Scoring functions for transcription factor binding site prediction

Markus Friberg, Peter von Rohr, Gaston Gonnet BMC Bioinformatics 2005, 6:84 (4 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Methodology article   Open Access Highly Accessed

Bayesian coestimation of phylogeny and sequence alignment

Gerton Lunter, István Miklós, Alexei Drummond, Jens Jensen, Jotun Hein BMC Bioinformatics 2005, 6:83 (1 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A fully Bayesian Markov chain Monte Carlo method combines multiple sequence alignment and phylogeny, while taking full account of their inter-dependence and reveals new biologically meaningful information that is not available through standard methods

Methodology article   Open Access

Super paramagnetic clustering of protein sequences

Igor V Tetko, Axel Facius, Andreas Ruepp, Hans-Werner Mewes BMC Bioinformatics 2005, 6:82 (1 April 2005)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central


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