Table 4

The expression of Bax and Bcl-2 protein and Bax/Bcl-2 ratio (mean ± SEM, IOD)

Groups (n)

Bax

Bcl-2

Bax/Bcl-2


Sham (8)

3.32 (0.92)

2.74 (1.03)

1.14 (0.22)

Depression (8)

9.47 (2.5)a

6.18 (2.21)a

1.55 (0.30)a

MI (13)

27.63 (5.61)a, b

9.42 (3.75)a

2.83 (0.51)a, b

Post-MI depression (7)

53.88 (16.18)a, b, c

14.82 (3.71)a, c

3.77 (0.64)a, b, c


There was a significantly higher ratio of Bax:Bcl-2 (mean ± SEM) in the myocardium in the depression, MI (myocardial infarction) and post-MI depression groups than in the sham group (a P < 0.01). Furthermore, in the post-MI depression and MI groups there was a significantly higher ratio of Bax:Bcl-2 than in the depression group(b P < 0.01), and in the post-MI group there was a significantly higher ratio of Bax:Bcl-2 than in the MI group (c P < 0.01).

Wang et al. BMC Medicine 2013 11:32   doi:10.1186/1741-7015-11-32

Open Data