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Clinical biomarkers

With the increasing sophistication of diagnostic processes and expanding knowledge about association between biomolecules, genomics and acute disease, interest in biomarkers is at an all time high. Although there are many research studies into validating and understanding the prognostic and diagnostic value of biomarkers, this remains a relatively young field in terms of actual translation to the clinic. This thematic series covers recent advances in the clinical applications of biomarkers across a range of medically-relevant topics, demonstrating that biomarkers for acute illness are moving into the mainstream clinic but also highlighting the work that still lies ahead to make them more clinically useful.

  1. Research article

    Collectives of diagnostic biomarkers identify high-risk subpopulations of hematuria patients: exploiting heterogeneity in large-scale biomarker data

    Ineffective risk stratification can delay diagnosis of serious disease in patients with hematuria. We applied a systems biology approach to analyze clinical, demographic and biomarker measurements (n = 29) col...

    Frank Emmert-Streib, Funso Abogunrin, Ricardo de Matos Simoes, Brian Duggan, Mark W Ruddock, Cherith N Reid, Owen Roddy, Lisa White, Hugh F O'Kane, Declan O'Rourke, Neil H Anderson, Thiagarajan Nambirajan and Kate E Williamson

    BMC Medicine 2013 11:12

    Published on: 17 January 2013

  2. Research article

    Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography

    More than a million diagnostic cardiac catheterizations are performed annually in the US for evaluation of coronary artery anatomy and the presence of atherosclerosis. Nearly half of these patients have no sig...

    William A LaFramboise, Rajiv Dhir, Lori A Kelly, Patricia Petrosko, John M Krill-Burger, Christin M Sciulli, Maureen A Lyons-Weiler, Uma R Chandran, Aleksey Lomakin, Robert V Masterson, Oscar C Marroquin, Suresh R Mulukutla and Dennis M McNamara

    BMC Medicine 2012 10:157

    Published on: 5 December 2012

  3. Correspondence

    A tool to facilitate clinical biomarker studies - a tissue dictionary based on the Human Protein Atlas

    The complexity of tissue and the alterations that distinguish normal from cancer remain a challenge for translating results from tumor biological studies into clinical medicine. This has generated an unmet nee...

    Caroline Kampf, Julia Bergman, Per Oksvold, Anna Asplund, Sanjay Navani, Mikaela Wiking, Emma Lundberg, Mathias Uhlén and Fredrik Ponten

    BMC Medicine 2012 10:103

    Published on: 12 September 2012

  4. Research article

    Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study

    Interleukin-22 (IL-22), recently identified as a crucial parameter of pathology in experimental liver damage, may determine survival in clinical end-stage liver disease. Systematic analysis of serum IL-22 in r...

    Bernd Kronenberger, Ina Rudloff, Malte Bachmann, Friederike Brunner, Lisa Kapper, Natalie Filmann, Oliver Waidmann, Eva Herrmann, Josef Pfeilschifter, Stefan Zeuzem, Albrecht Piiper and Heiko Mühl

    BMC Medicine 2012 10:102

    Published on: 11 September 2012

  5. Research article

    Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review

    Recent insights provide support for the treatment of cancer during pregnancy, a coincidence that poses both mother and fetus at risk. Our aim was to critically review studies on the physiologic variations duri...

    Sileny N Han, Anouk Lotgerink, Mina Mhallem Gziri, Kristel Van Calsteren, Myriam Hanssens and Frédéric Amant

    BMC Medicine 2012 10:86

    Published on: 8 August 2012

  6. Research article

    CD133+CXCR4+ colon cancer cells exhibit metastatic potential and predict poor prognosis of patients

    Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of the three leading causes of cancer-related deaths worldwide. Growing evidence suggests that a subset of cells exists among cancer ...

    Shan-shan Zhang, Zhi-peng Han, Ying-ying Jing, Shuang-fen Tao, Tie-jun Li, Hao Wang, Yang Wang, Rong Li, Yang Yang, Xue Zhao, Xiao-dong Xu, En-da Yu, Yao-cheng Rui, Hou-jia Liu, Li Zhang and Li-xin Wei

    BMC Medicine 2012 10:85

    Published on: 7 August 2012

  7. Research article

    Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker

    Germinal center kinase-like kinase (GLK, also termed MAP4K3), a member of the MAP4K family, may regulate gene transcription, apoptosis and immune inflammation in response to extracellular signals. The enhanced...

    Der-Yuan Chen, Huai-Chia Chuang, Joung-Liang Lan, Yi-Ming Chen, Wei-Ting Hung, Kuo-Lung Lai and Tse-Hua Tan

    BMC Medicine 2012 10:84

    Published on: 6 August 2012

  8. Research article

    Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer

    Febrile neutropenia is a frequently occurring and occasionally life-threatening complication of treatment for childhood cancer. Many biomarkers have been proposed as predictors of adverse events. We aimed to u...

    Robert S Phillips, Ros Wade, Thomas Lehrnbecher, Lesley A Stewart and Alex J Sutton

    BMC Medicine 2012 10:6

    Published on: 18 January 2012

  9. Minireview

    suPAR as a prognostic biomarker in sepsis

    Sepsis is the clinical syndrome derived from the host response to an infection and severe sepsis is the leading cause of death in critically ill patients. Several biomarkers have been tested for use in diagnos...

    Katia Donadello, Sabino Scolletta, Cecilia Covajes and Jean-Louis Vincent

    BMC Medicine 2012 10:2

    Published on: 5 January 2012

  10. Research article

    Myogenic progenitors contribute to open but not closed fracture repair

    Bone repair is dependent on the presence of osteocompetent progenitors that are able to differentiate and generate new bone. Muscle is found in close association with orthopaedic injury, however its capacity t...

    Renjing Liu, Oliver Birke, Alyson Morse, Lauren Peacock, Kathy Mikulec, David G Little and Aaron Schindeler

    BMC Musculoskeletal Disorders 2011 12:288

    Published on: 22 December 2011

  11. Research article

    Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer

    About half of Americans 50 to 75 years old do not follow recommended colorectal cancer (CRC) screening guidelines, leaving 40 million individuals unscreened. A simple blood test would increase screening compli...

    Jorja D Warren, Wei Xiong, Ashley M Bunker, Cecily P Vaughn, Larissa V Furtado, William L Roberts, John C Fang, Wade S Samowitz and Karen A Heichman

    BMC Medicine 2011 9:133

    Published on: 14 December 2011

  12. Opinion

    Biomarkers of acute lung injury: worth their salt?

    The validation of biomarkers has become a key goal of translational biomedical research. The purpose of this article is to discuss the role of biomarkers in the management of acute lung injury (ALI) and relate...

    Alastair G Proudfoot, Matthew Hind and Mark JD Griffiths

    BMC Medicine 2011 9:132

    Published on: 12 December 2011