Table 3

The expression of caspase 3, Bax and Bcl-2 mRNA and Bax/Bcl-2 ratio (mean ± SEM, copies/g RNA)

Groups

Casp-3 mRNA

Bax mRNA

BcL-2 mRNA

Bax/bcl-2


Sham (8)

0.66 (0.34)

2.85 (0.58)

0.88 (0.19)

3.29 (0.67)

Depression (8)

0.67 (0.08)

10.73 (1.20)a

1.97 (0.26) a

5.55 (1.28) b

MI (13)

0.92 (0.55)

23.23 (1.97)a, c

3.12 (0.10) a, c

7.47 (0.86) a, d

Post-MI Depression (7)

0.95 (0.42)

46.79 (2.75)a, c, e

5.08 (0.55) a, c, e

9.26 (0.67) a, c, f

F

0.481

333.978

93.541

24.171

P

0.704

0.000

0.000

0.000


The ratio of Bax:Bcl-2 (mean ± SEM) in the depression, MI (myocardial infarction) and post-MI depression groups was significantly larger than in the sham group (a P < 0.01, b P < 0.05), the MI and post-MI depression group was significantly larger than the depression group (c P < 0.01, d P < 0.05), and the post-MI depression group was a significantly greater than the MI group (e P < 0.01, f P < 0.05).

Wang et al. BMC Medicine 2013 11:32   doi:10.1186/1741-7015-11-32

Open Data