Table 2

Serum fatty acid profile in percentage by weight (wt%) measured in 723 participants

Non-diabetes HbA1c <5.7%

n = 380

Pre-diabetes HbA1c ≥5.7%

n = 259

Diabetesa

n = 84

Pb
Total FAs (mg/L) 3,790 (3,680 to 3,900)c 3,680 (3,560 to 3,810) 4,050 (3,820 to 4,300) 0.02
Saturated FAs 33.2 (32.9 to 33.4) 33.2 (32.9 to 33.5) 34.0 (33.5 to 34.5) 0.01
Monounsaturated FAs 22.9 (22.5 to 23.2) 23.2 (22.7 to 23.6) 24.0 (23.2 to 24.8) 0.03
n-6 PUFAs 35.0 (34.4 to 35.5) 34.5 (33.9 to 35.2) 32.8 (31.8 to 33.9) 0.002
n-3 PUFAs 7.2 (7.0 to 7.5) 7.4 (7.1 to 7.8) 7.2 (6.6 to 7.8) 0.61
α-Linolenic acid 0.71 (0.69 to 0.73) 0.73 (0.70 to 0.75) 0.72 (0.68 to 0.77) 0.38
Eicosapentaenoic acid 1.80 (1.68 to 1.92) 1.91 (1.76 to 2.07) 1.78 (1.54 to 2.05) 0.49
Docosapentaenoic acid (n-3) 0.62 (0.60 to 0.63) 0.63 (0.61 to 0.65) 0.62 (0.58 to 0.65) 0.55
Docosahexaenoic acid 3.69 (3.56 to 3.82) 3.73 (3.58 to 3.90) 3.63 (3.37 to 3.91) 0.79
n-3 PUFA / n-6 PUFA ratio 0.21 (0.20 to 0.22) 0.22 (0.20 to 0.23) 0.22 (0.20 to 0.24) 0.41

aDiabetes was defined as clinically diagnosed, or as having a fasting glucose ≥7.0 or a non-fasting glucose ≥11.1 mmol/L. bCalculated by using one-way analysis of covariance, after log transformation, adjusted for age, sex, and statin dose. cEstimated marginal means; 95% CI in parentheses (all such values). FAs, fatty acids; HbA1c, glycosylated hemoglobin; PUFAs, polyunsaturated fatty acids.

Strand et al.

Strand et al. BMC Medicine 2013 11:216   doi:10.1186/1741-7015-11-216

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